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Research
Dec 9th, 2024
TAU Discovery Decodes a Rare Neurological Disease
This breakthrough could pave the way for neurological treatments.
- Life Sciences
- Biology
Researchers at Tel Aviv University have developed an innovative research model that allowed them to decode the mechanism underlying a severe and rare neurological disease. The disease is characterized by symptoms such as epilepsy, developmental delay, and intellectual disability.
According to the researchers: "Decoding the disease mechanism is a critical step toward developing treatments targeting specific cellular functions for this disease and other conditions with similar mechanisms affecting cellular energy production".
The research was led by Tel Aviv University’s Prof. Abdussalam Azem, Dean of the Wise Faculty of Life Sciences, in collaboration with Prof. Uri Ashery and PhD student Eyal Paz from the School of Neurobiology, Biochemistry and Biophysics at the Wise Faculty of Life Sciences and the Sagol School of Neuroscience. Additional contributors included Dr. Sahil Jain and Dr. Irit Gottfried from the School of Neurobiology, Biochemistry, and Biophysics at Tel Aviv University, Dr. Orna Staretz-Chacham from the Faculty of Health Sciences at Ben-Gurion University, Dr. Muhammad Mahajnah from the Technion, and researchers from Emory University in Atlanta, USA. The findings were published in the prominent journal eLife.
TIMM50 Mutation Linked to Rare Brain Disorders
Prof. Azem explains: "The disease we studied is caused by a mutation in a protein called TIMM50, which plays a crucial role in importing other proteins into the mitochondria—the organelle considered the cell's energy powerhouse. The human mitochondria operate with about 1,500 proteins (approximately 10% of all human proteins), but only about 13 of them are produced within the mitochondria itself. The rest are imported externally through various mechanisms. In recent years, mutations in the TIMM50 protein, which is responsible for importing about 800 proteins into the mitochondria, were found to cause severe and rare neurological disease with symptoms like epilepsy, developmental delay, and intellectual disability".
Prof. Ashery adds: "Protein import into the mitochondria has been extensively studied over the years, but how a mutation in TIMM50 affects brain cells was never tested before. To investigate this for the first time, we created an innovative model using mouse neurons that mimics the disease caused by the TIMM50 protein mutation. In this study, we significantly reduced the expression of the protein in mouse brain cells and observed its impact on the cells".
How Does a Protein Defect Link Energy Loss to Epilepsy?
Eyal Paz explains: "The impairment of the protein led to two main findings: a reduction in energy production in the neurons, which could explain the developmental issues seen in the disease and an increase in the frequency of action potentials (the electrical signals that transmit information along neurons and enable communication between them). This increase in action potential frequency is known to be associated with epilepsy. The change in frequency is likely caused by significant damage to two proteins that function as potassium channels. Imbalances in potassium levels can lead to life-threatening conditions, such as arrhythmias, cardiac arrest, and muscle weakness, potentially leading to paralysis. These potassium channels may serve as potential targets for future drug treatments for the disease".
Prof. Azem concludes: "Our study decodes the mechanism of a severe and rare neurological disease caused by a mutation in a protein critical for importing proteins into the mitochondria. Understanding the mechanism is a crucial step toward treatment, as it enables the development of drugs targeting the specific issues identified. Additionally, we created a new research model based on mouse neurons that significantly advances the study of protein import into mitochondria in brain cells. We believe that our findings, combined with the innovative model, will enable more in-depth research and the development of treatments for various neurological diseases caused by similar mitochondrial dysfunction mechanisms".
Research
Dec 3rd, 2024
What Can Locusts Teach Us About Efficiency in Design?
Research shows locusts’ digging valves are built just right for their task.
- Life Sciences
Researchers at Tel Aviv University examined the mechanical wear of digging valves located at the tip of the female locust’s abdomen, used to dig pits for laying eggs 3 to 4 times during her lifetime. They found that, unlike organs with remarkably high wear resistance, such as the mandible (lower jaw), the valves wear down substantially due to intensive digging.
The researchers: “This is an instructive example of the ‘good enough’ principle in nature. Evolution saw no need to invest extra energy and resources in an organ with a specific purpose that performs its function adequately. We, humans, who often invest excessive resources in engineered systems, can learn much from nature”.
The study was led by Dr. Bat-El Pinchasik from the School of Mechanical Engineering and Prof. Amir Ayali from the School of Zoology at the Wise Faculty of Life Sciences, the Sagol School of Neuroscience and the Steinhardt Museum of Natural History at Tel Aviv University. Other participants included: PhD student Shai Sonnenreich from TAU's School of Mechanical Engineering, as well as researchers from the Technical University of Dresden in Germany, Prof. Yael Politi and a postdoc in her group, Dr. Andre Eccel Vellwock. The article was published in the prestigious journal Advanced Functional Materials.
Left to right: Prof. Amir Ayali, Dr. Bat-El Pinchasik & PhD student Shai Sonnenreich.
Dr. Pinchasik: “In my lab, we study mechanical mechanisms in nature, partly to draw inspiration for solving technological problems. Recently we collaborated with locust expert Prof. Amir Ayali in a series of studies, to understand the mechanism used by the female locust for digging a pit to lay her eggs. This unique mechanism consists of two shovel-like valves that open and close cyclically, digging into the soil while pressing the sand against the walls”.
Prof. Ayali: “We know that many mechanisms in the bodies of insects in general, and locusts in particular, are exceptionally resistant to mechanical wear. For example, the locust's mandibles, used daily for feeding, are made of a highly durable material. The digging valves, on the other hand, while subjected to substantial shear forces during digging, are used only 3 or 4 times in the female's lifetime - when she lays eggs. In this study, we sought to discover whether these digging valves, made of hard cuticular material, were also equipped by evolution with high resistance to mechanical wear”.
To address this question, the researchers examined the digging valves in three different groups of female locusts: young females that had not yet laid eggs, mature females kept in conditions that prevented them from laying eggs - to test whether age alone causes wear and adult females that had already laid eggs 3 or 4 times. To analyze the internal structure and durability of the digging valves, the researchers used several advanced technologies: confocal microscopy, 3D fluorescent imaging, and a particle accelerator (synchrotron) in collaboration with the German team. The findings indicated significant signs of wear in the valves and a lack of elements associated with high resistance to mechanical wear. Notably, no reinforcing metal ions, typical of extremely wear-resistant biological materials, were found in the valves.
Dr. Pinchasik: “A female locust's biological role is laying eggs three or four times in her life. In this study, we found that evolution has designed her digging valves to meet their task precisely—no more and no less. This is a wonderful example of the ‘good enough’ principle in nature: no extra resources are invested in an organ when they’re not needed".
“As humans, we can learn much from nature - about conserving materials, energy, and resources. As engineers who develop products, we must understand the need precisely and design an accurate response, avoiding unnecessary overengineering” - Dr. Pinchasik.
Research
Nov 28th, 2024
Exposing Hamas' Ground Movements on October 7th with Seismic Data
New research shows analysis of seismic data reveals Hamas' movements on October 7th.
- Environment
A groundbreaking study in the field of forensic seismology, conducted by Tel Aviv University researchers, has identified the seismic signature of Hamas forces' movement before the October 7th attack. Researchers from the Department of Geophysics at Tel Aviv University's Porter School of the Environment and Earth Sciences and Sackler Faculty of Exact Sciences recently analyzed data recorded at three seismic stations in southern Israel. The findings reveal that on the morning of October 7th, approximately half an hour before the deadly terrorist assault, the stations recorded weak but widespread human-induced seismic noise. The researchers attribute these anomalous seismic amplitudes to the unusual movement of heavy vehicles within the Gaza Strip heading toward organizational points along the Israeli border up to 20 minutes before the ground barrier breach.
The researchers explain that forensic seismology is often used to monitor conventional and nuclear explosions. However, this is the first time in history that weak ground motions resulting from preparations for a terrorist attack have been identified by analyzing the characteristics of seismic noise induced by vehicular traffic. They believe the discovery demonstrates the potential usage of seismic-based sensing technology to provide early warnings of terrorist activity. However, they emphasize that the identification of these movements in Gaza was conducted retrospectively, months after the attack.
The study, led by Dr. Asaf Inbal of the Department of Geophysics at Tel Aviv University's Porter School of the Environment and Earth Sciences and the Faculty of Exact Sciences, was published in The Seismic Record, a journal of the Seismological Society of America.
Dr. Inbal explains: "The Israeli Geological Survey operates a nationwide network of dozens of highly sensitive seismometers that continuously monitor ground motions. This network is primarily designed to detect and locate earthquakes and warn of strong ground shaking caused by large-magnitude seismic events. However, three stations in the network—located in Amazia, Ktsiot, and Yatir, between 30 and 50 kilometers from Gaza—recorded unusual seismic noise levels early in the morning of October 7th, 2023. This noise can be attributed with confidence to the vehicular activity in Gaza as Hamas terrorists gathered for the attack. The time frame was between 6:00 and 6:30 AM, before the rocket fire began. The likelihood that the recorded signals originated from Gaza is over 99.9%".
Detecting Terrorist Preparations with Seismic Waves
Although the seismometers are designed to detect extremely weak ground motions, Dr. Inbal points out that the ability to link the seismic noise to Gazan vehicle movements was facilitated by the quiet background seismic noise levels that prevailed in southern Israel during the early hours of that Saturday morning, which coincided with the holiday of Simchat Torah.
"The motions recorded near the seismometers were in the range of tens of nanometers per second, whereas the minimum ground motion detectable by humans is several millimeters per second", explains Dr. Inbal.
"The characteristics of the noise originating from Gaza and captured by the Israeli stations are fundamentally different from those recorded at the same stations on previous Saturdays during those hours. We analyzed three years of data from the Israeli station trio recorded in the same time frame as the one leading up to the attack. We found no instance of a Saturday morning when correlated amplitudes were recorded at all three stations for over 10 minutes. It's important to note that these stations are widely spaced, with each station primarily sensitive to seismic noise generated by nearby human activity. For instance, the distance between Ktsiot and Amazia is about 80 kilometers, and on previous Saturdays, there was no correlation between the data recorded at these stations. On the morning of the attack, when local activity near the stations was minimal, we found unique widespread seismic amplitudes, which monotonically increased with time approaching the attack. No known natural or human source on the Israeli side could have generated seismic signals with a distribution and intensity similar to those attributed to Hamas movements. Although the outdoor music festival near Re'im generated some seismic noise, our analysis shows that this noise does not match the strength or location of the noise sources recorded by the Israeli seismic network on October 7th".
Findings from the research.
New Insights Into Hamas' Movements on October 7th
The analysis indicates the seismic noise detected began at 6:00 AM and intensified as the attack approached. Occasionally, the noise contained short bursts strong enough to pinpoint their source and track their progress. The location and intensity of these sources in Gaza suggest vehicle movements advancing southward and northward within Gaza, from Rafah in the south to the Erez crossing in the north, during the 30 minutes leading up to the attack.
"We have good resolution along Salah al-Din Road, a major thoroughfare crossing Gaza from Rafah in the south to Beit Lahia in the north", says Dr. Inbal. "We can confirm with high certainty that their forces moved along this route at speeds of 25 to 50 km/h. Observations from stations dozens of kilometers from Gaza's border indicate convoys of heavy vehicles such as bulldozers and trucks carrying operatives. Three minutes before the attack began, we detected noise sources reaching the northern end of Gaza near Beit Lahia and the southern end near Khan Yunis. At the same time, we continued receiving signals from central Gaza, near Nuseirat. We know the assault began almost simultaneously along the entire border, so these seismic observations provide further evidence of the extensive deployment of Hamas forces, likely enabling the simultaneous breach of the ground barrier".
Dr. Inbal concludes: "This development results from five years of seismological research aimed at characterizing seismic noise generated by human activities. I hope this new knowledge will lead to the expanded use of such tools for both security and industrial purposes".
"We see graduates of the Department of Geophysics at Tel Aviv University playing a leading role in scientific and technological advancements, and we are confident that in the future, multi-purpose seismic-sensing technologies will be more widely used in various fields that impact our daily lives" - Dr. Inbal.
Research
Nov 25th, 2024
Does Looking Good Lead to Doing Good?
New study finds that feeling attractive can lead to more generosity and kindness.
- Management
Does the global beauty trend have positive social aspects as well? A new study from Tel Aviv University shows that people who make an effort to improve their appearance—whether this effort is real or imagined, in the physical world or on social media—act more kindly towards others and are twice as likely to donate to charity.
The surprising study was led by Dr. Natalia Kononov, who completed her doctorate under the supervision of Prof. Danit Ein-Gar at the Coller School of Management at Tel Aviv University and is now a postdoctoral fellow at the Wharton School of Business at the University of Pennsylvania. The study, conducted in collaboration with Prof. Ein-Gar and Prof. Stefano Puntoni of Wharton, was published in the International Journal of Research in Marketing.
Prof. Danit Ein-Gar (Photo credit: Israel Hadari).
“When we enhance our appearance and feel beautiful—for example, after a fresh haircut—we behave in a more socially conscious manner”, explains Prof. Ein-Gar. “Why? Because we feel as though all eyes are on us, drawing attention, and so we strive to act better. It’s easy to criticize the selfie generation, constantly beautifying themselves and sharing polished photos, but we demonstrate a side effect of this behavior that can benefit society. People who feel good about their appearance can channel that feeling into good deeds”.
Dr. Natalia Kononov.
To test their hypothesis, the researchers conducted a series of experiments, some in virtual settings and others in a laboratory. In one lab experiment, participants were asked to use a filter to enhance a selfie they had taken. A control group, meanwhile, was asked to enhance a photo of an object in the room.
“The experimental group consisted of 50 participants, as did the control group”, Prof. Ein-Gar explains. “After viewing their enhanced photo, each participant collected an envelope with their payment in cash. Next to the payment envelope, there was a donation box so participants could voluntarily donate some or all of their payment. We observed that members of the experimental group, who saw themselves as more attractive, donated up to twice as much as those in the control group. It’s enough to imagine ourselves as more attractive—even just envisioning a more polished digital version of ourselves—to encourage prosocial behavior. This insight has significant practical implications. Until now, research has focused on the appearance of the donation seekers—whether the recipient or the fundraiser—and indeed, more attractive fundraisers have been found to raise more money. Our study introduces another relevant factor: the donor’s appearance. This opens the door to innovative strategies for streamlining charity campaigns, such as partnering with cosmetic companies, hairdressers, and beauty salons—for everyone’s benefit”.
Beauty and the Benefit
One of the most surprising experiments was conducted virtually, on Facebook. Clicking on a link randomly directed users to one of two “know yourself” questionnaires. The control group’s questionnaire asked about preferred architectural styles, while the experimental group’s questionnaire included questions about fashion styles and was designed to make respondents imagine themselves at their most attractive moments, such as envisioning themselves dressed up for a fancy social event. At the end of the questionnaire, a seemingly unrelated pop-up appeared with a link to a donation page. About 7% of respondents who answered the “beauty” questionnaire clicked on the donation link, compared to approximately 2% of those who answered the architectural questionnaire—a particularly impressive figure considering the average click-through rate on Facebook links is just 0.9%.
“Our society is obsessively focused on physical appearance while simultaneously criticizing this superficial behavior”, says Dr. Kononov. “People who are appearance-focused are often judged harshly, but we show that this behavior can have positive spillover effects that benefit others. Social mechanisms may evolve to create some balance, where behaviors that serve the individual are accompanied by byproducts that contribute to the greater good“.
