Prof. Ella Sklan

Clinical Microbiology and Immunology

מיקרוביולוגיה ואימונולוגיה קלינית סגל אקדמי בכיר

Email: sklan@tauex.tau.ac.il

Phone: 03-6408197

Another phone: 03-6409486

Fax: 03-6409160

My CRIS profile

Lab website

Google Scholar

Office: Sackler School of Medicine, 807

CV

1993-1996 Bachelor of Science (B. Sc). in Biology, Ben-Gurion University, Beer-Sheva.

1996-1997 Masters of Medical Sciences (M. Med. Sci) Cum Laude. Health Sciences, Ben-Gurion University, Beer-Sheva.

1998-1999 Masters in Business Administration (MBA), School of Management, Ben-Gurion University, Beer-Sheva.

1999-2004 Ph.D., Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem.

2004-2008 Post-Doctoral Fellow, division of gastroenterology and hepatology, Stanford school of medicine, Stanford, CA

Academic Positions

Associate professor, Department of Clinical Immunology and Microbiology, Sackler Faculty of Medicine Tel-Aviv University.

Research

Our long-term goal is identification and characterization of the interactions of viruses with their host cells. Our current model systems include Sandfly viruses, Zika and Dengue viruses and Hepatitis viruses.

Current projects in the lab include:

CRISPR screens for or the identification and characterization of new interactions between viruses and host cells.
Using live cell imaging techniques to study viral-host interactions.
Identification of the mechanism of action of antiviral interferon stimulated genes.

Publications (last 3 years)

Lahav-Ariel L, Caspi M, Nadar-Ponniah PT, Zelikson N, Hofmann I, Hanson KK, Franke WW, Sklan EH, Avraham KB, Rosin-Arbesfeld R. (2019) Striatin is a novel modulator of cell adhesion. FASEB J.;33(4):4729-4740.
Dukhovny A, Lamkiewicz K, Chen Q, Fricke M, Jabrane-Ferrat N, Marz M, Jung JU, Sklan EH. (2019) A CRISPR Activation Screen Identifies Genes That Protect against ZikaVirus Infection. J Virol. 93(16).
Shlomai A., Ben Zvi H., Glusman Bendersky A., Shafran N., Goldberg E*, Sklan EH*. (2020) Nasopharyngeal viral load predicts hypoxemia and disease outcome in admitted COVID-19 patients. Critical Care, 24:539.
Hada-Neeman S. Weiss-Ottolenghi Y, Wagner N, Avram O, Maor Y, Sklan EH, Shcherbakov D, Pupko T, Gershoni JM. (2021) Domain-Scan: combinatorial sero-diagnosis of infectious diseases using machine learning. Frontiers in Immunology. 11:619896.
Goldberg E, Ben Zvi H, Sheena L, Sofer S, Krause I, Sklan EH*, Shlomai A*. (2021). A Real-life Setting Evaluation of the Effect of Remdesivir on Viral Load in COVID-19 Patients in a Large Tertiary Center in Israel. Clinical Microbiology and Infection. 27(6) 917.e1-917.e4.
Shomron O, Nevo-Yassaf I, Aviad T, Yaffe Y, Zahavi EE, Dukhovny A, Perlson E, Brodsky I, Yeheskel A, Pasmanik-Chor M, Mironov A, Beznoussenko GV., Mironov AA, Sklan EH, Patterson GH, Yonemura Y, Sannai M, Kaether C, Hirschberg K. (2021). COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers. J Cell Biol. 7;220(6):e201907224.
Shlomai A., Leshno A., Sklan EH*, Leshno M*. (2021) Modeling social distancing strategies to prevent SARS-CoV-2 spread in Israel- A Cost-effectiveness analysis. Value in Health, 24(5):607–614.
Shafran N, Shafran I, Ben-Zvi H, Sofer S, Sheena L, Krause I, Shlomai A*, Goldberg E*, Sklan EH*. (2021) Secondary bacterial infections in COVID-19 versus influenza patients and their association with mortality. Scientific reports, 11(1):12703.
Evron T, Kazelnik M, Caspi M, Manber Z, Elkon R, Sklan EH*, Rosin-Arbesfeld R.* (2021) A CRISPR Knockout Screen Reveals New Regulators of Canonical Wnt Signaling. *co-senior authors. Oncogenesis.10(9):63.
Sofer S, Lamkiewicz K, Armoza Eilat S. Partouche S, Marz M, Moskovits N, Stemmer S, Shlomai A*, and Sklan EH*. (2022). A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells. FASEB journal. 36(3):e22191.
Moalem Y, Malis Y, Voloshin K, Dukhovny A, Hirschberg K, Sklan EH. (2022). Sandfly fever viruses attenuate the type I interferon response by targeting the phosphorylation of JAK-STAT components. Frontiers in Immunology. 13:865797.
Siman-Tov R, Shalabi R, Shlomai A, Goldberg E, Essa W, Shusterman E, Ablin JN, Rosin-Arbesfeld R, Sklan EH. (2022). Elevated serum amyloid A levels in COVID-19 patients promote platelet adhesion. International Journal of Molecular Sciences. 23(22):14243.