Dr. Ella Sklan

  • Clinical Microbiology and Immunology
מיקרוביולוגיה ואימ.קליני סגל אקדמי בכיר
Dr. Ella Sklan
Phone: 03-6408197
Another phone: 03-6409486
Fax: 03-6409160
Office: Sackler School of Medicine, 807

Positions

Senior lecturer, Department of Clinical Immunology and Microbiology, Sackler Faculty of Medicine Tel Aviv University

 

Education

2004-2008 Post-Doctoral Fellow, division of Gastroenterology and Heapatology, Stanford University school of medicine, Stanford, CA.

 

1999-2004 Ph.D, Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem.

 

1998-1999 Masters in Business Administration (MBA), School of Management, Ben-Gurion University, Beer-Sheva.

 

Research

Our long-term goal is identification and characterization of the interactions of viruses with their host cells. Our current model systems include Ebola virus, Dengue virus and Hepatitis C and D viruses.

 

Current projects in the lab include:

  1. Development of systems for the identification and characterization of new interactions between viral and host cell proteins.
  2. Using live cell imaging techniques to study viral-host interactions.
  3. Identification of the mechanism of action of antiviral interferon stimulated genes.

 

Publications

Matto M*, Sklan EH*, David, N, Melamed-Book N, Casanova, JE, Glenn JS, Aroeti B. A Role for ADPribosylation factor 1 in the regulation of hepatitis C virus replication. (2011) J Virol, 85:946-56. *Equal contribution.


Lee C, Ma H, Hang JQ, Leveque V, Sklan EH, Elazar M, Klumpp K, Glenn JS. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. (2011). Virology, 414:10-8.


Nachmias D, Sklan EH, Ehrlich M, Bacharach E. Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. (2012) Retrovirology. 9:7.


Nevo-Yassaf I, Yaffe Y, Asher M, Ravid O, Eizenberg S, Henis YI, Nahmias Y, Hirschberg K, Sklan EH. Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A. (2012) J Virol. 86:6491-502.


Shlomai A, Rechtman MM, Burdelova EO, Zilberberg A, Hoffman S, Solar I, Fishman S, Halpern Z, Sklan EH. The metabolic regulator PGC-1a links hepatitis C virus infection to hepatic insulin resistance. (2012) J Hepatol. 57:867-73.

 

Stern O, Hung YF, Valdau O, Yaffe Y, Harris E, Hoffmann S, Willbold D, Sklan EH. An N terminal amphipathic helix in dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication. (2013) J Virol. 87:4080-5.

 

Hanin G, Shenhar-Tsarfaty S, Yayon N, Hoe YY, Bennett ER, Sklan EH, Rao DC, Rankinen T, Bouchard C, Geifman-Shochat S, Shifman S, Greenberg DS, Soreq H. Competing targets of microRNA-608 affect anxiety and hypertension. (2014) Hum Mol Genet. 23:4569-80


David, N, Yaffe Y, Hagoel L, Elazar M, Glenn JS, Hirschberg K, Sklan EH. (2015) The interaction between the Hepatitis C proteins NS4B and NS5A is involved in viral replication. Virology, 475C:139-149.


Cho NJ, Lee C, Pang P, Pham EM, Fram B, Nguyen K, Xiong A, Sklan EH, Elazar M, Koytak ES, Kersten C, Kanazawa KK, Frank CW, Glenn JS. (2015) Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A ligand and mediates replication of the viral genome. Gastroenterology, 148:616-25.

 

Hung Y, Schwartena M, Schünkea S, Thiagarajan- Rosenkranza P, Hoffmann S, Sklan EH, Willbold D, Koenig B. (2015) Dengue virus NS4A cytoplasmic domain binding to liposomes stabilizes membrane curvature. BBA – Biomembranes. 184:8 1119-1126.


Yaffe Y, Hagger I, Nevo Yassaf I, Shepshelovitch J, Sklan EH, Elkabetz Y, Yeheskel A, Pasmanik-Chor M, Benzing C, Macmillan A, Gaus K, Eshed-Eisenbach Y, Peles E, Hirschberg K. (2015) The myelin proteolipid Plasmolipin, forms oligomers and induces liquid ordered membranes in the Golgi apparatus. J Cell Sci, 128:2293-302.


Hung Y, Schwarten M, Hoffmann S, Willbold D, Sklan EH, Koenig B. (2015). Amino terminal region of Dengue virus NS4A cytosolic domain binds to highly curved liposome. Viruses, 7, 4119-4130.

 

Levy G, Bomze D, Heinz S, Ramachandran SD, Noerenberg A, Cohen M, Shibolet O, Sklan E, Braspenning J, Nahmias Y. (2015) Long-term culture and expansion of primary human hepatocytes. Nat Biotechnol. 33:1264-1271.

 

Feldman M, Hershkovitz I, Sklan EH, Kahila Bar-Gal G, Pap I, Szikossy I, Rosin-Arbesfeld R. (2016). Detection of a tumor suppressor gene variant predisposing to colorectal cancer in an 18th century Hungarian mummy. PLoS One.11:e0147217.

 

Levy G, Habib N, Guzzardi M.A, Kitsberg D, Bomze D, Ezra E, Uygun B.E, Uygun K, Trippler M, Schlaak, J.F, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y. (2016) Nuclear receptors control pro and anti-viral metabolic response to HCV infection. Nature Chem Biol. In press.

 

Grants

  • 2012-2016 Israel Science Foundation (ISF) Grant

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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