Dr. Ella Sklan

  • Clinical Microbiology and Immunology
מיקרוביולוגיה ואימ.קליני סגל אקדמי בכיר
Dr. Ella Sklan
Phone: 03-6408197
Another phone: 03-6409486
Fax: 03-6409160
Office: Sackler School of Medicine, 807

CV

1993-1996 Bachelor of Science (B. Sc). in Biology, Ben-Gurion University, Beer-Sheva.

1996-1997  Masters of Medical Sciences (M. Med. Sci) Cum Laude. Faculty of Health Sciences, Department of Immunology and Microbiology, Ben-Gurion University, Beer-Sheva.

1998-1999 Masters in Business Administration (MBA), School of Management, Ben-Gurion University, Beer-Sheva.

1999-2004 Ph.D, Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem.

2004-2008 Post-Doctoral Fellow, division of gastroenterology and hepatology, Stanford school of medicine, Stanford, CA

Academic Positions

2008- Senior lecturer, Department of Clinical Immunology and Microbiology, Sackler Faculty of Medicine Tel-Aviv University.

2016-2017 Visiting Scholar, Department of Immunology and Microbiology, Keck School of Medicine at University of Southern California.

Research Interests

Our long-term goal is identification and characterization of the interactions of viruses with their host cells. Our current model systems include Sandfly viruses, Zika and Dengue viruses and Hepatitis viruses.

 

Current projects in the lab include:

  1. CRISPR screens for or the identification and characterization of new interactions between viruses and host cells.
  2. Using live cell imaging techniques to study viral-host interactions.
  3. Identification of the mechanism of action of antiviral interferon stimulated genes.

 

Publications

Sklan EH, Staschke K, Oakes TM, Elazar M, Winters M, Aroeti B, Danieli T, Glenn JS.(2007) A Rab-GAP TBC Domain Protein Binds Hepatitis C Virus NS5A and Mediates Viral Replication. J Virol. 81(20):11096-105

Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS. (2007) TBC1D20 is A Rab1 GAP That Mediates Replication. JBC, 282(50):36354-61 Grisaru D and Soreq H  (2008) Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J. Cell. Mol. Med. 2(2):479-9527

Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel M, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, Barreto dos Santos F, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding S, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS., Fire AZ. (2010).  Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems. PLOS Pathogens, 6(2) e1000764

Matto M, Sklan EH, David N, Melamed-Book N, Casanova JE, Glenn JS, Aroeti B. (2011).  A Role for ADP-Ribosylation Factor 1 in the Regulation of Hepatitis C Virus Replication. J. Virol, 85(2):946-56

Lee C, Ma H, Hang JQ, Leveque V, Sklan EH, Elazar M, Klumpp K, Glenn JS. (2011). The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. Virology. 25:414(1):10-8

Nachmias D, Sklan EH, Ehrlich M, Bacharach E. Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. (2012). Retrovirology, 9:7

Nevo-Yassaf I, Yaffe Y, Asher M, Ravid O, Eizenberg S, Henis YI, Nahmias Y, Hirschberg K, Sklan EH. A role for TBC1D20 and Rab1 in Hepatitis C virus replication via interaction with LD bound NS5A. (2012). Journal of virology, 86(12):6491-502

Shlomai A, Mouler Rechtman M, Burdelova O, Zilberberg A, Hoffman S, Solar I, Fishman S, Halpern Z and Sklan EH  (2012). The metabolic regulator PGC-1α links HCV infection to hepatic insulin resistance. Journal of Hepatology 57(4):867-73.

Stern O, Hung Y, Valdau O, Yaffe Y, Harris E, Hoffmann S, Willbold D, Sklan EH. (2013). An N-terminal amphipathic helix in the Dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication. Journal of Virology, 87(7) 4080-4085

Hanin G, Shenhar-Tsarfaty S, Yayon N, Hoe YY, Bennett ER, Sklan EH, Rao DC, Rankinen T, Bouchard C, Geifman-Shochat S, Shifman S, Greenberg DS, Soreq H. (2014) Competing targets of microRNA-608 affect anxiety and hypertension. Human Molecular Genetics. 23(18) 4569-80.

David, N, Yaffe Y, Hagoel L, Elazar M, Glenn JS, Hirschberg K, Sklan EH. (2015) The interaction between the Hepatitis C proteins NS4B and NS5A is involved in viral replication. Virology, 475C:139-149

Cho NJ, Lee C, Pang P, Pham EM, Fram B, Nguyen K, Xiong A, Sklan EH, Elazar M, Koytak ES, Kersten C, Kanazawa KK, Frank CW, Glenn JS. (2015) Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A Ligand and Mediates Replication of the Viral Genome. Gastroenterology, 148 (3):616-25

Hung Y, Schwartena M, Schünkea S, Thiagarajan-Rosenkranza P, Hoffmann S, Sklan EH, Willbold D, Koenig B. (2015) Dengue virus NS4A cytoplasmic domain binding to liposomes stabilizes membrane curvature. BBA – Biomembranes. 1848(5) 1119-1126

Feldman M, Hershkovitz I, Sklan EH, Kahila Bar-Gal G, Pap I, Szikossy I, Rosin-Arbesfeld R. (2016). Detection of a Tumor Suppressor Gene Variant Predisposing to Colorectal Cancer in an 18th Century Hungarian Mummy. PLoS One. 10;11(2): e0147217

Levy G, Habib N, Guzzardi M.A, Kitsberg D, Bomze D, Ezra E, Uygun B.E, Uygun K, Trippler M, Schlaak, J.F, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y. (2016) Nuclear Receptors Control Pro- and Anti-Viral Metabolic Response to HCV Infection. Nature Chemical Biology. 12(12):1037-104

Nevo-Yasaf, I. Lovelle, M. Nahmias, Y. Hirschberg K. Sklan EH. (2017) Live cell Imaging and analysis of lipid droplets biogenesis in HCV infected cells. Methods.  pii: S1046-2023(16)30491-1

Seo GJ, Kim C, Shin W, Sklan EH, Eoh H, Jung JU (2018) TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing. Nature Communication, In Press

Shirazi R, Ram D, Rakovsky A, Gozlan Y, Bucris E, Shaked-Mishan P, Picard O, Shemer-Avni Y, Ben-Zvi5 H, Halutz O, Lurie Y, Safadi R, Mendelson E. Sklan EH, Ben-Ari Z, Mor O. (2018) Hepatitis delta seroprevalence and molecular characterization of hepatitis B and delta coinfection in Israel. BMC Infectious Diseases. In Press

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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