Prof. Miguel Weil

Dep. of Cell Research and Immunology
מח חקר התא ואימונולוגיה סגל אקדמי בכיר
Prof. Miguel Weil
Phone: 03-6406981
Fax: 03-6422046
Office: Britannia-Porter, 231

Research Interests

My research interests include:

  • The role of programmed cell death (PCD) in the developing nervous system.
  • Molecular signaling pathways that regulate, PCD and cell proliferation which determine cell numbers at the time of neural tube closure in the chicken embryo.
  • Regulation of the apoptotic pathway in the neural tube cells and their implication in neural tube defects.
  • Cell cycle regulation in the developing neuroepithelia of the chicken embryo and its effects on neural tube development.
  • Neuronal differentiation of human embryonic and adult stem cells to study Familial Dysautonomia (FD) and other neurodegenerative disceases


Recent Publications

N. Plachta, A. Traister, M. Weil . Nitric oxide is involved in establishing the balance between cell cycle progression and cell death in the developing neural tube. Experimental Cell Research, Vol. 288, 2003 (pp. 354-362).


D. Makarovsky, Y. Kalechman, T. Sonino, I. Freidkin, S. Teitz, M. Albeck, M. Weil , R.Geffen-Aricha, G Yadid, B. Sredni Tellurium compound AS101 induces PC12 differentiation and rescue the neurons from apoptotic death. Annals of the New York Academy of Sciences, Vol.1010, 2003 (pp.659-666).


M. Weil , R. Abeles, A. Nachmany, V. Gold, E. Michael. Folic acid rescues nitric oxide-induced neural tube closure defects. Cell Death and Differentiation, Vol. 11, 2004 (pp. 361-363).


A. Traister, S. Abashidze, V. Gold, R. Yairi, E. Michael, N. Plachta, I. McKinnell, K. Patel, A. Fainsod, M. Weil . BMP controls nitric oxide mediated regulation of cell numbers in the developing neural tube. Cell Death and Differentiation, Vol. 11, 2004 (pp. 832-841).


T. Cohen, L. Ravid, N. Altman, L. Madar-Shapiro, A. Fein, M. Weil , M. Horowitz. Conservation of expression and alternative splicing in the prosaposin gene. Molecular Brain Research, Vol. 129, 2004 (pp. 8-19).


A. Nachmany, V. Gold, A. Tsur, D. Arad, M. Weil . Neural tube closure depends on nitric oxide synthase activity. Journal of Neurochemistry, Vol. 96, 2006 (pp. 247-253).


A. Rufini, M. Weil , F. McKeon, A. Barlattani, G. Melino, E. Candi. p63 protein is essential for the embryonic development of vibrissae and teeth. Biochem Biophys Res Commun. Vol. 340, 2006 (pp. 737-741).


L. Solmesky, M. Abekasis, S. Bulvik, M. Weil . BMP signaling is involved in human mesenchymal stem cells survival in serum free medium. Stem Cells and Dev. 2009 in Press.


D. Makarovsky, A. Nachmany, B. Sredni, M Weil . Excessive NOS activity induced by the immunomodulator AS101 triggers neuroepithelial apoptosis and blocks neural tube closure. 2009 Submitted for publication.


E. Karchovsky, V. Gold, A. Tsur, R. Yairi, R. Reshef, M. Weil . Shh controls BMP induced apoptosis extracellularly in the developing neural tube. 2009 Submitted for publication.


A. Tsur, A. Nachmany, Y. Kloog, M. Weil . Inhibition of Ras-PI3K and Ras-MAPK pathways affect differently neural tube closure and cell numbers in the chick embryo. 2009 Submitted for publication.


M. Valensi-Kurtz, S. Lefler, R. Cohen-Kupiec, A. Sheinin, M. Cohen, U. Ashery, B. Reubinoff, M. Weil . Enriched PNS neuron population derived from human ESC: a platform to study the role of the Familial Dysautonomia protein IKAP/hELP1. 2009 Submitted for publication.


Solmesky LJ, Abekasis M, Bulvik S, Weil M. Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium. Stem Cells Dev. 2009 Nov;18(9):1283-92. doi: 10.1089/scd.2009.0020. PubMed PMID: 19473100.

Valensi-Kurtz M, Lefler S, Cohen MA, Aharonowiz M, Cohen-Kupiec R, Sheinin A, Ashery U, Reubinoff B, Weil M. Enriched population of PNS neurons derived from human embryonic stem cells as a platform for studying peripheral neuropathies. PLoS One. 2010 Feb 18;5(2):e9290. doi: 10.1371/journal.pone.0009290. PubMed PMID: 20174633; PubMed Central PMCID: PMC2823780.

Cohen-Kupiec R, Weinstein S, Kantor G, Peer D, Weil M. IKAP/hELP1 down-regulation in neuroblastoma cells causes enhanced cell adhesion mediated by contactin overexpression. Cell Adh Migr. 2010 Oct-Dec;4(4):541-50. doi: 10.4161/cam.4.4.12923. PubMed PMID: 20671422; PubMed Central PMCID: PMC3011265.

Solmesky L, Lefler S, Jacob-Hirsch J, Bulvik S, Rechavi G, Weil M. Serum free cultured bone marrow mesenchymal stem cells as a platform to characterize the effects of specific molecules. PLoS One. 2010 Sep 10;5(9). doi:pii: e12689. 10.1371/journal.pone.0012689. PubMed PMID: 20844755; PubMed Central PMCID: PMC2937025.

Cohen-Kupiec R, Pasmanik-Chor M, Oron-Karni V, Weil M. Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. PLoS One. 2011 Apr 29;6(4):e19147. doi: 10.1371/journal.pone.0019147. PubMed PMID: 21559466; PubMed Central PMCID: PMC3084765.

Solmesky LJ, Shuman M, Goldsmith M, Weil M, Peer D. Assessing cellular toxicities in fibroblasts upon exposure to lipid-based nanoparticles: a high content analysis approach. Nanotechnology. 2011 Dec 9;22(49):494016. doi: 10.1088/0957-4484/22/49/494016. Epub 2011 Nov 21. PubMed PMID: 22101838.

Nachmany H, Wald S, Abekasis M, Bulvik S, Weil M. Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis. Dis Markers. 2012;32(4):211-20. doi: 10.3233/DMA-2011-0885. PubMed PMID: 22430187.


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