Prof. Inna Slutsky

פיזיולוגיה ופרמקולוגיה סגל אקדמי בכיר
Phone: 03-6406021
Another phone: 03-6406074
Fax: 03-6409113
Office: Sackler School of Medicine


Associate Professor, Department of Physiology & Pharmacology, Sackler Faculty of Medicine

Editorial Board Member: eLife, Scientific Reports, Frontiers in Cellular and Molecular Neuroscience;

Member, American Federation for Aging Research (AFAR) National Scientific Advisory Council;

Member, Minerva grant committee;

Member, Azrieli Ph.D .fellowship committee;

Member, Ph.D. program committee, Sagol School of Neuroscience

Member, Scientific Committee, Center of Nanoscience and Nanotechnology



Regulation of Hippocampal Plasticity: Single Synapses to Alzheimer’s Disease

The research in the laboratory is focused on understanding the basic mechanisms underlying synaptic function and primary mechanisms initiating synaptic dysfunction at very early stages of Alzheimer’s Disease. To achieve this goal, we developed an integrated system that enables simultaneous real-time visualization of structural reorganization in spatially-restricted signaling complexes and functional modifications of single synapses in brain circuits. Utilizing FRET spectroscopy, high-resolution optical imaging, electrophysiology, molecular biology, and biochemistry we explore experience-dependent mechanisms regulating the number and plasticity of hippocampal synapses under physiological and pathological conditions.



Gazit N, Vertkin I, Shapira I, Helm M, Slomowitz E, Sheiba M, Mor Y, Rizzoli S, Slutsky I. (2016) IGF-1 receptor differentially regulates spontaneous and evoked transmission via mitochondria at hippocampal synapses, Neuron 89, 583-597.


Frere S., Slutsky I. (2016) Targeting PTEN interactions for Alzheimer’s disease, Nature Neuroscience 19, 416-418.

Vertkin I, Styr B, Slomowitz E, Ofir N, Shapira I, Berner D, Fedorova T, Laviv T, Barak-Broner N, Greitzer- Antes D, Gassmann M, Bettler B, Lotan I, Slutsky I. (2015) GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks, Proc Natl Acad Sci USA 112, E3291-3299.

Slomowitz E, Styr B, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M, Slutsky I. (2015). Interplay between population firing stability and single neuron dynamics in hippocampal networks. Elife 4.


Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O’Malley T, Slomowitz E, Berdichevsky Y, Walsh Dominic M, Isacoff Ehud Y, Hirsch Joel A, Slutsky I (2014) APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses. Cell Reports,


Becker W, Shcheslavkiy V, Frere S, Slutsky I. (2014) Spatially resolved recording of transient fluorescence-lifetime effects by line-scanning TCSPC. Microsc Res Tech. 77:216-24


Dolev I*, Fogel H*, Milshtein H, Berdichevsky Y, Lipstein N, Brose N, Gazit N, Slutsky I (2013) Spike bursts increase amyloid-beta 40/42 ratio by inducing a presenilin-1 conformational change. Nature Neurosci. 16: 587-595.


Laviv T, Vertkin I, Berdichevsky Y, Fogel H, Riven I, Bettler B, Slesinger PA, Slutsky I. (2011) Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. J Neurosci. 31:12523-12532.


Laviv, T., Riven, I., Dolev, I., Vertkin, I., Balana, B., Slesinger, P. A., and Slutsky, I. (2010). Basal GABA Regulates GABA(B)R Conformation and Release Probability at Single Hippocampal Synapses. Neuron 67, 253-267.


Slutsky, I., Abumaria, N., Wu, L. J., Huang, C., Zhang, L., Li, B., Zhao, X., Govindarajan, A., Zhao, M. G., Zhuo, M., Tonegawa, S., Liu, G. (2010). Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron 65, 165-177.


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