Dr. Orna Gera Granot

Dr. Orna Gera, a lecturer and a researcher at the School of Health Professions, Department of Physiotherapy. Holds BPT and MSc with honors from the Department of Physiotherapy, a PhD from the Department of Physiology and Pharmacology at the Faculty of Medicine, Tel Aviv University. Researcher and clinician, with extensive clinical experience in rehabilitation.

Her research focuses on central and peripheral nerve and muscle diseases. Her research is conducted at the Neurology Research Center in Sheba hospital and is performed in cell lines, animal models for neurological impairment, in healthy subjects and in subjects suffering from nerve or muscle disease.

Itsekson-Hayosh, Z., Shavit-Stein, E., Last, D., Goez, D., Daniels, D., Bushi, D., Gera, O., Zibly, Z., Mardor, Y., Chapman, J., & Harnof, S. (2015). Thrombin Activity and Thrombin Receptor in Rat Glioblastoma Model: Possible Markers and Targets for Intervention? Journal of Molecular Neuroscience, 56(3). https://doi.org/10.1007/s12031-015-0512-y

Bushi, D*., Gera, O*., Kostenich, G., Shavit-Stein, E., Weiss, R., Chapman, J., & Tanne, D. (2016). A novel histochemical method for the visualization of thrombin activity in the nervous system. Neuroscience, 320. *Equally contributing first authors. https://doi.org/10.1016/j.neuroscience.2016.01.065

Gera, O., Shavit-Stein, E., Bushi, D., Harnof, S., Shimon, M. Ben, Weiss, R., Golderman, V., Dori, A., Maggio, N., Finegold, K., & Chapman, J. (2016). Thrombin and protein C pathway in peripheral nerve Schwann cells. Neuroscience, 339, 587–598. https://doi.org/10.1016/j.neuroscience.2016.10.034

Bushi, D., Stein, E. S., Golderman, V., Feingold, E., Gera, O., Chapman, J., & Tanne, D. (2017). A linear temporal increase in thrombin activity and loss of its receptor in mouse brain following ischemic stroke. Frontiers in Neurology, 8(APR). https://doi.org/10.3389/fneur.2017.00138

Gera, O., Bushi, D., Ben Shimon, M., Artan-Furman, A., Harnof, S., Maggio, N., Dori, A., Chapman, J., & Shavit-Stein, E. (2018). Local Regulation of Thrombin Activity by Factor Xa in Peripheral Nerve Schwann Cells. Neuroscience. https://doi.org/10.1016/j.neuroscience.2017.12.035

Golderman, V., Shavit-Stein, E., Gera, O., Chapman, J., Eisenkraft, A., & Maggio, N. (2018). Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. Journal of Molecular Neuroscience. https://doi.org/10.1007/s12031-018-1228-6

Shavit-Stein, E., Aronovich, R., Sylantiev, C., Gera, O., Gofrit, S. G., Chapman, J., & Dori, A. (2019). Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis. Frontiers in Neurology, 9(January), 3–12. https://doi.org/10.3389/fneur.2018.01139

Shavit-Stein, E., Sheinberg, E., Golderman, V., Sharabi, S., Wohl, A., Gofrit, S. G., Zivli, Z., Shelestovich, N., Last, D., Guez, D., Daniels, D., Gera, O., Feingold, K., Itsekson-Hayosh, Z., Rosenberg, N., Tamarin, I., Dori, A., Maggio, N., Mardor, Y., … Harnof, S. (2018). A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma. Frontiers in Neurology, 9(December), 1–11. https://doi.org/10.3389/fneur.2018.01087

Gera, O., Shavit-Stein, E., & Chapman, J. (2019). The Effect of Neuronal Activity on Glial Thrombin Generation. Journal of Molecular Neuroscience, 67(4), 589–594. https://doi.org/10.1007/s12031-019-01265-4

Golderman, V., Gofrit, S. G., Maggio, N., Gera, O., Gerasimov, A., Laks, D., Chapman, J., & Shavit-Stein, E. (2020). A novel highly sensitive method for measuring inflammatory neural-derived apc activity in glial cell lines, mouse brain and human csf. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21072422

Mindel, E., Weiss, R., Bushi, D., Gera, O., Orion, D., Chapman, J., & Shavit-Stein, E. (2020). Increased brain plasmin levels following experimental ischemic stroke in male mice. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24764

Shavit-Stein, E., Gofrit, S. G., Gayster, A., Teldan, Y., Ron, A., Bandora, E. A., Golderman, V., Gera, O., Harnof, S., Chapman, J., & Dori, A. (2020). Treatment of diabetic neuropathy with a novel PAR1-targeting molecule. Biomolecules. https://doi.org/10.3390/biom10111552

Shavit-Stein, E., Rahal, I. A., Bushi, D., Gera, O., Sharon, R., Gofrit, S. G., Pollak, L., Mindel, K., Maggio, N., Kloog, Y., Chapman, J., & Dori, A. (2020). Brain protease activated receptor 1 pathway: A therapeutic target in the superoxide dismutase 1 (SOD1) mouse model of amyotrophic lateral sclerosis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21103419