Prof. Shimon Efrat

Emeritus in Human Molecular Genetics Biochemistry
גנטיקה מולקולרית של אדם וביוכימיה אמריטוס
Prof. Shimon Efrat
Phone: 03-6407701
Another phone: 03-6407986
Fax: 03-6409950
Office: Sackler School of Medicine, 1007


Professor, Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel Aviv University

Nancy Gluck Regan Chair in Juvenile Diabetes



Cell Replacement Therapy for Diabetes

Our research focuses on the development of a cell replacement therapy for diabetes, in which the insulin-producing pancreatic beta cells are destroyed or malfunction. Our approaches for generation of an abundant source of cells for transplantation include expansion and differentiation in tissue culture of beta cells from human organ donors, as well as differentiation of human stem cells into insulin-producing cells.


Publications and Grants


Bar-Nur O, Russ HA, Efrat S, Benvenisty N (2011) Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 9:17-23


Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, Toren G, Farhy C, Pasmanik-Chor M, Oron-Karni V, Ravassard P, Efrat S (2011) Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One 6:e25566


Bar Y, Russ HA, Anker-Kitai L, Knoller S, Efrat S (2012) Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J Biol Chem 287:17269-17280


Lenz A, Toren-Haritan G, Efrat S. (2014) Redifferentiation of Adult Human β Cells Expanded In Vitro by Inhibition of the WNT Pathway. PLoS One. 9:e112914


 Nathan G, Kredo-Russo S, Geiger T, Lenz A, Kaspi H, Hornstein E, Efrat S (2015) miR-375 promotes redifferentiation of adult human β cells expanded in vitro. PLoS One 10: e0122108


Sintov E, Nathan G, Knoller S, Pasmanik-Chor M, Russ HA, Efrat S (2015) Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro. Sci Rep 5:13024


Toren-Haritan G, Efrat S (2015) TGFβ pathway inhibition redifferentiates human pancreatic islet β cells expanded in vitro. PLoS One 10: e0139168




Russ HA, Efrat S (2011) In-vivo functional assessment of engineered human insulin-producing cells. In Cell Transplantation, Soto-Gutierrez A, Navarro-Alvarez N, Fox IJ (eds.), Methods in Bioengineering, Yarmush ML, Langer RS (eds.), Artech House, pp. 35-46


Russ HA, Efrat S (2011) Development of human insulin-producing cells for cell therapy of diabetes. Ped Endocrinol Rev 9:590-597


Efrat S, Russ HA (2012) Making beta cells from adult tissues. Trends Endocrinol Metab 23:278-285


Efrat S (2013) Recent progress in generation of human surrogate beta cells. Curr Opin Endocrinol Diab Obes 20:259-264


Bar Y, Efrat S (2014) The Notch pathway in beta-cell growth and differentiation. In The Pancreatic Beta Cell, Litwack G (ed.), Vitamins and Hormones vol. 95, Academic Press/Elsevier, pp. 391-405




2011-2014 Beta-cell replacement by human islet beta cells expanded in vitro, Israel Science Foundation (ISF)
2012-2017           Stem cells for biological assays of novel drugs and predictive toxicology, Innovative Medicines Initiative (IMI)
2013-2015   Redifferentiation of expanded human beta-cell-derived cells for cell therapy of diabetes, Israel Ministry of Industry, Trade, and Labor Kamin Program
2013-2017 Generation of human insulin-producing cells by redifferentiation of cells expanded from pancreatic islet beta cells through inhibition of the NOTCH pathway, Israel Science Foundation (ISF)


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