Prof. Ehud Gazit

CV

Education:
1997-2000	Postdoctoral Fellow; Massachusetts Insitute of Technology- Cambridge, MA
1997	Ph.D (with distinction); Weizmann Institute of Science- Rehovot, Israel
1991	B.Sc. (summa cum laude); Special University Program for Outstanding Students, Tel Aviv University
Academic and Vising Appointments
2019-2021	Umeå University, Department of Medical Biochemistry and Biophysics, Gästprofessor (Visiting Professor)
2018-2019	Fudan University, Department of Physics, Senior Visiting
2016	Cambridge University, St. John’s College Beaufort Senior
2008-2012	Biochemistry and Biophysics Visiting Professor
2008-2012	Vice President for Research and Development; Tel Aviv University
2008-present	Chair for Nano-Biology (Cathedra); Tel Aviv University
2007-present	Professor; Dept of Mol. Microbiology and Biotechnology, TAU
2005-2007	Associate Professor; Dept of Mol. Microbiology and Biotechnology, TAU
2002- 2005	Senior Lecturer, Dept of Mol. Microbiology and Biotechnology, TAU
2000-2002	Lecturer, Dept of Mol. Microbiology and Biotechnology, TAU
2002-2011	Visiting Scientist, Center for Biomedical Engineering, MIT
Honors and Awards:
2020	Landau Prize in Sciences and Arts in the Field of Healthy Aging
2019	Rappaport Prize for Excellence in the Field of Biomedical Research
2018	Foreign Fellow, National Academy of Sciences, India (FNASc)
2017	EMBO Keynote Lecture, BioMAT 2017, Weimer, Germany
2016	ERC Advanced Grant, European Research Council
2016	Thomas McMahon Lecture, Harvard University
2015	Elected Member of the European Molecular Biology Organization (EMBO)
2015	Kadar Family Award for Outstanding Research
2009	Herstin Award for a leading scientist under the age of 44
2008	Selection for the list of 100 Innovations from academic Research to Real-World Application, 2008 Better World Report, The association of University Technology Managers (AUTM)
2007	Selection by The Marker magazine for the prestigious 40/40 list of 40 identified young Israeli leaders up to the age of 40 from all sectors of society forecasted to lead future Israel
2006	Prize for excellence in research, The Research Council, Tel Aviv University
2003	Minerva Foundation Fellowship
2002	Dan David Scholarship Award
1999	Landau Research Award, Miphal Hapais fund, Tel-Aviv, Israel
1998	Finalist, Amersham Pharmacia Biotech and Science Prize for Young Scientists
1998	Post-doctoral fellowship, Human Frontiers Science Program
1997	Post-doctoral fellowship, EMBO
1997	Certificate of Excellence for Students in High Education Institutes, awarded by the Committee of Education of the Knesset (the Israeli parliament).
1997	Weizmann Institute of Science, The John F. Kennedy Award (highest award given by the Feinberg Graduate School)
1995	Clore Foundation Program Doctoral Scholarship
1994	UBU IIIUBMB fellowship for participating in the Young Scientists Program of the tnernatiInternational Congress of Biochemistry
1994	Ciba Foundation Bursary

Professional Activities:
2012-2014	Chief Scientist of the Ministry of Science and Technology
2010-present	Journal of Peptide Science, Editorial Board Member
2010-present	Nanoscience & Nanotechnology - Asia, Editorial Board Member
2007-present	Amyloid, Editorial Board Member
2007-2009	PLoS ONE, Editorial Board Member
2007-2009	Deputy member, University Committee for Appointments and promotions, TAU, Israel
2006-present	Academic Coordinator, The biology-Chemistry double major track, TAU, Israel
2006-present	Current Chemical Biology, Editorial Board Member
2005-2011	Nanomedicine, Editorial Board Member
2005-present	Journal of Bionanoscience, Editorial Board Member
2005-2010	Expert, European Observatory of Nanobiotechnology (EoN).
2003-2009	Member of the International Relations Committee, Biophysical Society

Research Interests

My lab is interested in Molecular Structure and Self-Assembly at the Nano-Scale.

The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead to much interest in the significance and mechanism of formation of such unfolded, misfolded or partially folded structures in physiological as well as pathological conditions.

In our lab we utilize a variety of biochemical, biophysical and molecular biology methodologies to study the mechanism and significance of protein unfolding and misfolding. The experimental systems used are diverse and the partial list includes several bacterial toxin-antidote systems, type II diabetes-related amyloidogenic proteins and peptides, and the VHL tumor suppressor protein. We also study the mechanism of non-specific aggregation of generic unrelated proteins. Another line of research is directed toward the elucidation of the mechanism of action of chemical chaperons and their effect on folding, aggregation and amyloid formation.

For a more details on specific lab activities, please read the full research description.

Recent Publications

For the full list

Recent Publications

281. Zaguri, D., Shaham-Niv, S., Naaman, E., Mimouni, M., Magen, D., Pollack, S., Kreiser, T., Leibu, R., Rencus-Lazar, S., Adler-Abramovich, L., Perlman, I., Gazit, E. & Zayit-Soudry, S. (2020) Induction of Retinopathy by Fibrillar Oxalate Assemblies. Commun. Chem. 3, 2.

282. Schnaider, L., Arnon, Z. & Gazit, E. (2020) Reevaluating the Microbial Infection Link to Alzheimer's Disease. J. Alzheimer's Dis. 73, 59-62.

283. Viswanathan, G.K., Shwartz, D., Losev, Y., Arad, E., Shemesh, C., Pichinuk, E., Engel, H., Raveh, A., Jelinek, R., Cooper, I., Gosselet, F., Gazit, E. & Segal, D. (2020) Purpurin Modulates Tau-derived VQIVYK Fibrillization and Ameliorates Alzheimer’s Disease-Like Symptoms in Animal Model. Cell. Mol. Life Sci. 77, 2795-2813.

284. Tao, K., Donnell, J. O., Yuan, H., Haq, E.U., Guerin, S., Shimon, L.J.W., Xue, B., Silien, C., Cao, Y., Thompson, D., Yang, R., Syed, T.A.M. & Gazit, E. (2020) Accelerated Charge Transfer in Water-Layered Peptide Assemblies. Energy Environ. Sci. 13, 96-101.

285. Chakraborty, P., Tang, Y., Yamamoto, T., Yao, Y., Guterman, T., Zilberzwige‐Tal, S., Adadi, N., Ji, W., Dvir, T., Ramamoorthy, A., Wei, G. & Gazit, E. (2020) Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator. Adv. Mater. 32, e1906043.

286. Tao, K., Chen, Y., Orr, A.A., Tian, Z., Makam, P., Gilead, S., Si, M., Rencus-Lazar, S., Qu, S., Zhang, M., Tamamis, P. & Gazit, E. (2020) Enhanced Fluorescence for Bioassembly by Environment-Switching Doping of Metal Ions. Adv. Funct. Mater. 2020, 1909614.

287. Bera, S., Xue, B., Rehak, P., Jacoby, G., Ji, W., Shimon, L.J.W., Beck, R., Král, P., Cao, Y. & Gazit, E. (2020) Self-Assembly of Aromatic Amino Acid Enantiomers into Supramolecular Materials of High Rigidity. ACS Nano 14, 1694-1706.

288. Chakraborty, P., Ji, W., Rahmany, S., Etgar, L. & Gazit, E. (2020) Formation of Semiconducting Supramolecular Fullerene Aggregates in a Dipeptide Organogel. Adv. Mater. Technol. 2020, 1900829.

289. Chen, Y., Orr, A., Tao, K., Wang, Z., Ruggiero, A., Shimon, L.J.W., Schnaider, L., Goodall, A., Rencus-Lazar, S., Sharon, G., Slutsky, I., Tamamis, P., Tan, Z. & Gazit, E. (2020) High-Efficiency Fluorescence through Bioinspired Supramolecular Self-Assembly. ACS Nano 14, 2798-2807.

290. Schnaider, L., Rosenberg, A., Kreiser, T., Kolusheva, S., Gazit, E. & Berman, J. (2020) Peptide Self-Assembly is Linked to Antibacterial, but not Antifungal, Activity of Histatin 5 Derivatives. mSphere 5, e00021-20

291. Chen, Y., Tao, K., Ji, W., Makam, P., Rencus-Lazar, S. & Gazit, E. (2020) Self-Assembly of Cyclic Dipeptides: Platforms for Functional Materials. Protein Pep. Lett. 27, 1-10.

292. Schnaider, L., Toprakcioglu, Z., Ezra, A., Xizhou, L., Bychenko, D., Levin, A., Gazit, E. & Knowles, T. P. J. (2020) Biocompatible Hybrid Organic/Inorganic Micro-Hydrogels Promote Bacterial Adherence and Eradication In Vitro and In Vivo. Nano Lett. 20, 1590-1597.

293. Abu-Hussien, M., Viswanathan, G.K., Haj, E., Paul, A., Gazit, E. & Segal, D. (2020) An Amyloidogenic Hexapeptide from the Cataract-Associated γD-crystallin is a Model for

the Full-Length Protein and is Inhibited by Naphthoquinone-Tryptophan Hybrids. Int. J. Biol. Macromol. 157, 424-433.

294. Zaguri, D., Shaham-Niv, S., Chakraborty, P., Arnon, Z., Makam, P., Bera, S., Rencus-Lazar, S., Stoddart, P., Gazit, E., & Reynolds, N. (2020) Nanomechanical Properties and Phase Behavior of Phenylalanine Amyloid Ribbon Assemblies and Amorphous Self-Healing Hydrogels. ACS Appl. Mater. Interfaces 12, 21992-22001.

295. Ji, W., Yuan, C., Chakraborty, P., Pandeeswar, M., Bera, S., Rencus-Lazar, S., Li, J., Yan, X. & Gazit, E. (2020) Co-Assembly Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials. ACS Nano 14, 7181-7190.

296. Basavalingappa, V., Bera, S., Xue, B., O'Donnell, J., Guerin, S., Cazade, P-A., Yuan, H., Haq, E., Silien, C., Tao, K., Shimon, L., Tofail, S., Thompson, D., Kolusheva, S., Yang, R., Cao, Y. & Gazit, E. (2020) Diphenylalanine-Derivative Peptide Assemblies with Increased Aromaticity Exhibit Metal-Like Rigidity and High Piezoelectricity. ACS Nano 14, 7025–7037.

297. Basavalingappa, V., Xue, B., Rencus-Lazar, S., Wang, W., Cao, Y. & Gazit, E. (2020) Self-Assembled Quadruplex-Inspired Peptide Nucleic Acid Tetramer for Artificial Photosynthesis. ChemPhotoChem 4, 5154-5158.

298. Levin, A., Hakala, T., Schnaider, L., Bernardes, G., Gazit, E. & Knowles, T.P.J. (2020) Biomimetic Peptide Self-Assembly for Functional Materials. Nature Rev. Chem. 4, 615-634.

299. Pansieri, J., Iashchishyn, I.A., Fakhouri, H., Ostojić, L., Malisauskas, M., Musteikyte, G., Smirnovas, V., Schneider, M.M., Scheidt, T., Xu, C.K., Meisl, G., Knowles, T.P.J., Gazit, E., Antoine, R. & Morozova-Roche, L.A. (2020) Templating S100A9 Amyloids on Aβ Fibrillar Surfaces Revealed by Charge Detection Mass Spectrometry, Microscopy, Kinetic and Microfluidic Analyses. Chem. Sci. 11, 7031-7039.

300. Ke, P.C., Zhou, R., Serpell, L.C., Riek, R., Knowles, T.P.J., Lashuel, H.A., Gazit, E., Hamley, I.W., Davis, T.P., Fändrich, M., Otzen, D.E., Chapman, M.R., Dobson, C.M., Eisenberg, D.S. & Mezzenga, R. (2020) Half a Century of Amyloids: Past, Present and Future. Chem. Soc. Rev. 49, 5473-5509.

301. Tao, K., Tang, Y., Rencus-Lazar, S., Yao, Y., Xue, B., Gilead, S., Wei, G. & Gazit, E. (2020) Bioinspired Supramolecular Packing Enables High Thermo-Sustainability. Angew. Chem. Intl. Ed. 59, 19037-19041.

302. Paul, A., Zacco, E., Frenkel-Pinter, M., Alvarez, D.E., Milordini, G., Gazit, E. & Segal, D. (2020) Tryptophan-Galactosylamine Conjugates Inhibit and Disaggregate Amyloid Fibrils of Aβ42 and hIAPP Peptides while Reducing their Toxicity. Commun. Biol. 3, 484.

303. Ji, W., Xue, B., Bera, S., Guerin, S., Liu, Y., Yuan, H., Li, Q., Yuan, C., Shimon, L.J.W., Ma, Q., Kiely, E., Tofail, S.A.M., Si, M., Yan, X., Cao, Y., Wang, W., Yang, R., Thompson, D., Li, J. & Gazit E. (2020) Tunable Mechanical and Optoelectronic Properties of Organic Co-crystals by Unexpected Stacking Transformation from H- to J- and X-Aggregation. ACS Nano 14, 10704-10715.

304. O'Donnell, J., Guerin, S., Makam, P., Cazade, P-A., Haq, E.U.I., Tao, K., Gazit, E., Silienac, C., Souliman, T., Damien, T. & Tofail, S.A.M. (2020) Atomistic-Benchmarking towards a Protocol Development for Rapid Quantitative Metrology of Piezoelectric Biomolecular Materials. Appl. Mater. Today 21, 1000818.

305. Tao, K., Xue, B., Han, S., Aizen, R., Shimon, L., Xu, Z., Cao, Y., Mei, D., Wang, W. & Gazit, E. (2020) Bioinspired Suprahelical Frameworks as Scaffolds for Artificial Photosynthesis. ACS Appl. Mater. Interfaces 12, 45192-45201.

306. Naaman, E., Ya'ari, S., Itzkovich, C., Safuri, S., Macsi, F., Kellerman, L., Mimouni, M., Mann, I., Gazit, E., Adler-Abramovich, L. & Zayit-Soudry, S. (2020) The Retinal Toxicity Profile Towards Assemblies of Amyloid-β Indicate the Predominant Pathophysiological Activity of Oligomeric Species. Sci. Rep. 10, 20954.

307. Paul, A., Huber, A., Rand, D., Gosselet, F., Cooper, I., Gazit, E. & Segal D. (2020) Naphthoquinone-Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils and Attenuate Aggregate-Induced Toxicity. Chem. Eur. J. 26, 16486-16496.

308. Chakraborty, P., Tang, Y., Guterman, T., Arnon, Z. A., Yao, Y., Wei, G. & Gazit, E. (2020) Co-Assembly between Fmoc Diphenylalanine and Diphenylalanine within 3D Fibrous Viscous Network Confers Atypical Curvature and Branching. Angew. Chem. Int. Ed. Engl. 59, 23731-23739.

309. Mondal, A., Brown, N., Mishra, S., Makam, P., Wing, D., Gilead, S., Wiesenfeld, Y., Leitus, G., Shimon, L., Carmielli, R., Ehre, D., Kamieniarz, G., Fransson, J., Hod, O., Kronik, L., Gazit, E. & Naaman, R. (2020) Long-Range Spin-Selective Transport in Chiral Metal-Organic Crystals with Temperature-Activated Magnetization. ACS Nano 14, 16624–16633.

310. Schnaider, L., Shimonov, L., Kreiser, T., Zaguri, D., Bychenko, D., Brickner, I., Kolusheva, S., Lichtenstein, A., Kost, J. & Gazit, E. (2021) Ultrashort Cell Penetrating Peptides for Enhanced Sonophoresis-Mediated Transdermal Transport. ACS Appl. Bio Mater. 3, 8395–8401.

311. Ji, W., Xue, B., Bera, S., Guerin, S., Shimon, L. J. W., Ma, Q., Tofail, S. A. M., Thompson, D., Cao, Y., Wang, W. & Gazit, E. (2021) Modulation of Physical Properties of Organic Cocrystals by Amino Acid Chirality. Mater. Today 42, 29-40.

312. Levkovich, S.A., Gazit, E. & Laor Bar-Yosef, D. (2021) Two Decades of Studying Functional Amyloids in Microorganisms. Trends Microbiol. 29, 251-265.

313. Losev, Y., Frenkel-Pinter, M., Abu-Hussien, M., Krishnakumar, G.V., Elyashiv-Revivo, D., Geries, R., Khalaila, I., Gazit, E. & Segal, D. (2021) Differential Effects of Putative N-Glycosylation Sites in Human Tau on Alzheimer's Disease-Related Neurodegeneration. Cell Mol. Life Sci. 78, 2231–2245.

314. Levkovich, S. A., Rencus-Lazar, S., Gazit, E. & Laor Bar-Yosef, D. (2021) Microbial Prions: Dawn of a New Era. Trends Biochem. Sci. 46, 391-405.

315. Abu-Hussien, M., KrishnaKumar, V.G., Borisover, L., Mimouni, M., Engel, H., Zayit-Soudry, S., Gazit, E. & Segal, D. (2021) Inhibition of Amyloid Fibrillation of γD-crystallin Model Peptide by the Cochineal Carmine. Int. J. Biol. Macromol. 169, 342-351.

316. Milardi, D., Gazit, E., Radford, S., Xu, Y., Gallardo, R., Caflisch, A., Westermark, G.T., Westermark, P., La Rosa, C. & Ramamoorthy, A. (2021) Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes. Chem. Rev. 121, 1845–1893.

317. Paul, A., Viswanathan, G.K., Huber, A., Arad, E., Engel, H., Jelinek, R., Gazit, E. & Segal, D. (2021) Inhibition of Tau Amyloid Formation and Disruption of its Preformed Fibrils by Naphthoquinone-Dopamine Hybrid. FEBS J. (in press).

318. Wiernik, G., Mishra, N.K., Mondal, S., Ali, R., Gazit, E. & Verma, S. (2021) A Colored Hydrophobic Peptide Film Based on Self-Assembled Two-Fold Topology. J. Colloid Interface Sci. 594, 326-333.

319. Bera, S., Dong, X., Krishnarjuna, B., Raab, S., Hales, D., Ji, W., Tang, Y., Shimon, L., Ramamoorthy, A., Clemmer, D., Wei, G. & Gazit, E. (2021) Solid State Packing Dictates the Unexpected Solubility of Aromatic Peptides. Cell Rep. Phys. Sci. 2, 100391.

320. Dong, X., Bera, S., Qiao, Q., Tang, Y., Lao, Z., Luo, Y., Gazit, E. & Wei, G. (2021) Liquid–Liquid Phase Separation of Tau Protein Is Encoded at the Monomeric Level. J. Phys. Chem. Lett. 12, 2576–2586.

321. Chakraborty, P., Oved, H., Bychenko, D., Yao, Y., Tang, Y., Zilberzwige‐Tal, S., Wei, G., Dvir, T. & Gazit, E. (2021) Nano-Engineered Peptide-Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering. Adv. Mater. (in press).

322. O’Donnell, J., Cazade, P-A., Guerin, S., Djeghader, A., Ul Haq, E., Tao, K., Gazit, E., Fukada, E. Silien, C., Soulimane, T., Thompson, D. & Tofail, S.A.M. (2021) Piezoelectricity of the Transmembrane Protein ba3 Cytochrome c Oxidase. Adv. Funct. Mater. (in press).

323. Bera, S., Guerin, S., Yuan, H., O'Donnell, J., Reynolds, N.P., Maraba, O., Ji, W., Shimon, L.J.W., Cazade, P.A., Tofail, S.A.M., Thompson, D., Yang, R. & Gazit E. (2021).

Molecular Engineering of Piezoelectricity in Collagen-Mimicking Peptide Assemblies. Nat. Commun. 12, 2634

LIST OF ISSUED US PATENTS

1. Reches, M., & Gazit, E. (2009) Peptide Nanostructures and Methods of Generating and Using the Same. US Patent 7,491,699.

2. Gazit, E., & Reches, M. (2009) Peptide Nanostructures Encapsulating a Foreign material and Method of Manufacturing Same. US Patent 7,504,383.

3. Gazit, E., & Cherny, I. (2009) Antibacterial Agents and Methods of Identifying and Utilizing Same. US Patent 7,625,707.

4. Gazit, E., & Cohen, T. (2010) Compositions for Treating Amyloid Associated Diseases. US Patent 7,732,479.

5. Gazit, E. (2010) Peptides Directed for Diagnosis and Treatment of Amyloid-Associated Disease. US Patent 7,491,699.

6. Reches, M., & Gazit, E. (2010) Peptide Nanostructures Containing End-Capping Modified Peptides and Methods of Generating and Using the Same. US Patent 7,786,086.

7. Yemini, M., Reches, M., Rishpon, J., & Gazit, E. (2011) Peptide Nanostructure-Coated Electrodes. US Patent 7,879,212.

8. Gazit, E. (2011) Peptides Directed for Diagnosis and Treatment of Amyloid-Associated Diseases. US Patent 8,012,929.

9. Gazit, E., & Reches, M. (2011) Peptide Nanostructures Encapsulating a Foreign Material and Method of Manufacturing Same. US Patent 8,017,586.

10. Reches, M., & Gazit, E. (2011) Peptide Nanostructures and Methods of Generating and Using the Same. US Patent 8,053,554.

11. Gazit, E., & Reches, M. (2012) Peptide Nanostructures Encapsulating a Foreign Material and Method of Manufacturing Same. US Patent 8,314,069.

12. Reches, M., & Gazit, E. (2013) Peptide Nanostructures and Methods of Generating and Using the Same. US Patent 8,350,004.

13. Gazit, E., & Porat, Y. (2013) Compositions and Methods using Same for Treating Amyloid-Associated Diseases. US Patent 8,372,880.

14. Gazit, E., & Reches, M. (2013) Peptide Nanostructures Encapsulating a Foreign Material and Method of Manufacturing Same. US Patent 8,501,697.

15. Shaltiel-Karyo, R., & Gazit, E. (2013) Compositions and Methods for Treatment of Neurodegenerative Diseases. US Patent 8,546,330.

16. Gazit, E. (2013) Method of Screening for Compounds that Disaggregate Amyloid Aggregates. US Patent 8,563,273.

17. Nelson, N., Yacoby, I., Gazit, E., & Benhar, I. (2013) Photocatalytic Hydrogen Production in Cyanobacteria. US Patent 8,563,294.

18. Reches, M., & Gazit, E. (2013) Method of Forming a Fiber Made of Peptide Nanostructures. US Patent 8,568,637.

19. Gazit, E. (2014) Peptides and Methods using Same for Diagnosis and Treatment of Amyloid-Associated Disease. US Patent 8,697,634.

20. Scherzer, R., Gazit, E., & Segal, D. (2014) Naphthoquinone Derivatives useful for Prevention of Amyloid Deposits and Areatment of Diseases Involving Amyloidogenesis. US Patent 8,697,680.

21. Nelson, N., Yacoby, I., Gazit, E., & Benhar, I. (2014) Photocatalytic Hydrogen Production in Cyanobacteria. US Patent 8,741,598.

22. Reches, M., & Gazit, E. (2014) Peptide Nanostructures Containing End-Capping Modified Peptides and Methods of Generating and Using the Same. US Patent 8,796,023.

23. Gazit, E., Adler-Abramovich, L., Aronov, D., & Rosenman, G. (2014) Vapor Deposition of Biomolecules. US Patent 8,802,193.

24. Gazit, E., & Cohen, T. (2014) Compositions for Treating Amyloid Associated Diseases. US Patent 8,889,729.

25. Reches, M., & Gazit, E. (2015) Peptide Nanostructures and Methods of Generating and Using the Same. US Patent 8,927,689.

26. Gazit, E. (2015) Peptides and Methods using Same for Diagnosis and Treatment of Amyloid-Associated Disease. US Patent 8,993,510.

27. Adler-Abramovich, L., Carny, O., & Gazit, E. (2015) Compositions and Methods for Diagnosing and treating phenylketonuria (PKU). US Patent 9,061,006.

28. Aviv, M., Buzhansky, L., Einav, S., Nevo, Z., Gazit, E., & Adler-Abramovich, L. (2015) Malleable Hydrogel Hybrids made of Self-Assembled Peptides and Biocompatible Polymers and Uses thereof. US Patent 9,074,095.

29. Gazit; E., Amir, Y., Buzhansky, L., Abel, U., & Frydman-Marom, A. (2015) Dipeptide Analogs for Treating Conditions Associated with Amyloid Fibril Formation. US Patent 9,096,645.

30. Yacoby, I., Gazit, E., Nelson, N., & Benhar, I. (2015) Photocatalytic Hydrogen Production and Polypeptides Capable of Same. US Patent 9,181,555.

31. Shaltiel-Karyo, R., & Gazit, E. (2016) Compositions for Treatment of Neurodegenerative Diseases. US Patent 9,243,032.

32. Scherzer, R., Gazit, E. & Segal, D. (2016) Naphthoquinone Derivatives Useful for Prevention of Amyloid Deposits and Treatment of Diseases Involving Amyloidogenesis. US Patent 9,272,993.

33. Gazit, E., & Reches, M. (2016) Method of Forming a Fiber Made of Peptide Nanostructures. US Patent 9,394,628.

34. Aviv, M., Buzhansky, L., Einav, S., Nevo, Z., Gazit, E., & Adler-Abramovich, L. (2017) Malleable Hydrogel Hybrids Made of Self-Assembled Peptides and Biocompatible Polymers and Uses Thereof. US Patent 9,610,353.

35. Bram, Y., & Gazit, E. (2017) Methods of Treating Diabetes and Compositions Capable of Same. US Patent 9,624,285.

36. Gazit; E., Amir, Y., Buzhansky, L., Abel, U., & Frydman-Marom, A. (2017) Dipeptide Analogs for Treating Conditions Associated with Amyloid Fibril Formation. US Patent 9,630,989.

37. Berger, O., Adler-Abramovich, L., & Gazit, E. (2017) Self-Assembled Peptide Nucleic Acids. US Patent 9,741,948

38. Marco, P., Adler-Abramovich, L., & Gazit, E. (2017) Self-Assembled Peptide Nanostructures. US Patent 9,790,254.

39. Gazit, E., Mahler, A., & Reches, M. (2018) Self-Assembled Fmoc-ff Hydrogels. US Patent 10,004,828.

40. Gazit. E., & Reches, M. (2018) Formation of Organic Nanostructure Array. US Patent 10,086,354.

41. Aviv, M., Buzhansky, L., Einav, S., Nevo, Z., Gazit, E., & Adler-Abramovich, L. (2019) Malleable Hydrogel Hybrids Made of Self-Assembled Peptides and Biocompatible Polymers and Uses Thereof. US Patent 10,245,351

42. Kostenich, G., Oron-Herman, M., Orenstein, A., Shekhter-Zahavi, T., Gazit, E., Salitra, Y., & Buzhansky, L. (2019) Synthetic Somatostatin Receptor Ligands. US Patent 10,266,579.

43. Berger, O., Adler-Abramovich, L., & Gazit, E. (2019) Self-Assembled Peptide Nucleic Acids. US Patent 10,446,768.

44. Genady, K., Oron-Herman, M., Orenstein, A., Shekhter-Zahavi, T., Gazit, E., Salitra, Y., & Buzhansky, L. (2020) Synthetic Somatostatin Receptor Ligands. US Patent 10,723,780.

List of Top 20 Publications

1. Gazit, E.* (2002) The “Correctly-Folded” State of Proteins: Is it a Metastable State? Angew. Chem. Int. Ed. Engl. 41, 257-259 (English) / Gazit E.* (2002) "Korrekt gefaltete" Protein - ein metastabiler Zustand? Angew. Chem. 114, 267-269 (German).

2. Reches, M., & Gazit, E.* (2003) Casting Metal Nanowires within Discrete Self-Assembled Peptide Nanotubes. Science 300, 625-627.

3. Carny, O. & Gazit, E.* (2005) A Model for the Role of Short Self-Assembled Peptides in the very Early Stages of the Origin of Life. FASEB J. 19, 1051-1055.

4. Reches, M., & Gazit, E.* (2006) Controlled Patterning of Aligned Self-Assembled Peptide Nanotubes. Nature Nanotech. 1, 195-200. (Featured on the cover of the issue and in a "News and Views" article at: Nature Nanotech. 1, 169-170).

5. Mahler, A., Reches, M., Rechter, M., Cohen, S. & Gazit, E.* (2006). Rigid, Self-Assembled Hydrogel Composed of a Modified Aromatic Dipeptide. Adv. Mater. 18, 1365-1370.

6. Adler-Abramovich, L., Aronov, D., Beker, P., Yevnin, M., Stempler, S., Buzhansky, L., Rosenman, G.*, & Gazit, E.* (2009) Self-assembled Arrays of Peptide Nanotubes by Vapour Deposition. Nature Nanotech. 4, 849-854.

7. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Frenkel, D., & Gazit, E.* (2012) Phenylalanine Assembly into Toxic Fibrils Suggests Amyloid Etiology in Phenylketonuria. Nature Chem. Biol. 8, 701-706. (Featured on the cover of the issue).

8. Berger, O., Adler-Abramovich, L., Levy-Sakin, M., Grunwald, A., Liebes-Peer, Y., Bachar, M., Buzhansky, L., Mossou, E., Forsyth, V.T., , Schwartz, T., Ebenstein, Y., Frolow, F., Shimon, L. J. W., Patolsky, F., & Gazit, E.* (2015) Light-Emitting Self-Assembled Peptide Nucleic Acids Exhibit both Stacking Interactions and Watson-Crick Base Pairing. Nature Nanotech. 10, 353-360 [Featured on the cover of the issue as well as on the cover of the 10th anniversary issue of Nature Nanotechn (October 2016 – "A decade of small wonders"), and in a "News and Views" article at: Nature Nanotech. 10, 295-296].

9. Shaham-Niv, S., Adler-Abramovich, L., Schnaider, L., & Gazit, E.* (2015) Extension of the Generic Amyloid Hypothesis to Non-Proteinaceous Metabolite Assemblies. Science Adv. 1, e1500137.

10. Mondal, S., Adler-Abramovich, L., Lipman, S., & Gazit E.* (2016) Formation of Functional Super-Helical Assemblies by Constrained Single Heptad Repeat. Nature Commun. 6, 8615.

11. Levin, A., Michaels, T. C. T., Adler-Abramovich, L., Mason, T. O., Mueller, T., Mahadevan, L., Gazit, E.*, & Knowles, T. P. J.* (2016) Elastic Instability-Mediated Actuation by a Supramolecular Polymer. Nature Physics 12, 926–930.

12. Guterman, T., Kornreich, M., Stern, A., Adler-Abramovich, L., Porath, D., Beck, R., Shimon, L., & Gazit, E.* (2016) Formation of Bacterial Pilus-Like Nanofibers by Designed Minimalistic Self-Assembling Peptides. Nature Commun. 7, 13482.

13. Tao, K., Makam, P., Aizen, R., & Gazit, E.* (2017) Self-Assembling Peptide Semiconductors. Science 358, eaam9756.

14. Schnaider, L., Brahmachari, S., Schmidt, N.W., Mensa, B., Shaham-Niv, S., Bychenko, D., Adler-Abramovich, L., Shimon, L.J.W., Kolusheva, S., DeGrado, W. F.*, & Gazit, E.* (2017) Self-Assembling Dipeptide Antibacterial Nanostructures with Membrane Disrupting Activity. Nature Commun. 8, 1365.

15. Yuan, C., Ji, W., Xing, R., Li, J.*, Gazit, E.*, & Yan, X.* (2019) Hierarchically Oriented Organization in Supramolecular Peptide Crystals. Nature Rev. Chem. 3, 567–588.

16. Laor, D., Sade, D., Shira Shaham-Niv, S., Zaguri, D., Gartner, M., Basavalingappa, V., Raveh, A., Pichinuk, E., Engel, H., Iwasaki, K., Yamamoto, T., Noothalapati, H., & Gazit, E.* (2019) Fibril Formation and Therapeutic Targeting of Amyloid-Like Structures in a Yeast Model of Adenine Accumulation. Nature Commun. 10, 62.

17. Bera, S., Mondal, S., Xue, B., Shimon, L. J. W., Cao, Y., & Gazit, E.* (2019) Rigid Helical-like Assemblies from a Self-Aggregating Tripeptide. Nature Mater. 18, 503–509.

18. Makam, P., Yamijala, S. S. R. K. C., Tao, K., Shimon, L. J. W., Eisenberg, D. S., Sawaya, M. R., Wong, B. M., & Gazit, E.* (2019) Nonproteinaceous Hydrolase Comprised of Phenylalanine Metallosupramolecular Amyloid-Like Structure. Nature Catal. 2, 977–985. (Featured in a "News and Views" article at: Nature Catal. 2, 949–950).

19. Levin, A., Hakala, T., Schnaider, L., Bernardes, G., Gazit, E. & Knowles, T.P.J. (2020) Biomimetic Peptide Self-Assembly for Functional Materials. Nature Rev. Chem. 4, 615-634.

20. Tao, K., Tang, Y., Rencus-Lazar, S., Yao, Y., Xue, B., Gilead, S., Wei, G. & Gazit, E.* (2020) Bioinspired Supramolecular Packing Enables High Thermo-Sustainability. Angew. Chem. Intl. Ed. 59, 19037-19041 (Selected as "Hot Paper" by the journal).

PUBLICATIONS

A. BOOKS

1. Gazit E. (2007) Plenty of Room for Biology at the Bottom: Introduction to Bionanotechnology (196 pp.). Imperial College Press, London, UK. ISBN 1-86094-677-1.

Second Edition: Gazit E., Mitraki A. (2013) Plenty of Room for Biology at the Bottom: Introduction to Bionanotechnology. 2nd Edition. Imperial College Press, London, UK. ISBN 1-84816-930-2 (Shortlisted of the Postgraduates Textbook Prize at the Society of Biology Book Awards Competition of 2014).

Translated to Russian: Газит E. (2011) Нанобиотехнология: необъятные перспективы развития. Nanobiotehnologiya. Neobyatnye perspektivy razvitiya.

2. Gazit, E., and R. Nussinov (Eds.) (2008) Nanostructure Design Protocols: Methods in Molecular Biology. Humana Press, Totowa NJ, USA. ISBN 1-93411-535-5.

B. Chapters in books

1. Gazit, E. & Shai, Y. (1993) Membrane Interaction and Hemolytic Activity of the Alpha-5 Helix of delta-endotoxin. In: Wei, Y. H., Chen, C. S., & Su, J. C. (Eds.) Recent Advances in Molecular and Biochemical Research on Proteins. (pp. 145-153) World Scientific Publishing Co. Pte. Ltd., Singapore.

2. Gazit, E., Flajnik, M. K., Boman, H. G., Zasloff, M., Merrifield, R. B., Shal, H. G., Elsbach, P., Andreu, D., Hultmark, D. & Natori, S. (1994) On The Mechanism of Membranes Permeation by Cecropin B2 (General discussion). In: Boman, H.G., Marsh, J., & Goode, J. (Eds.), John Wiley & Sons Ltd., Chichester, UK. Ciba Found. Symp. 186, 190-196.

3. Gazit, E. (2003) Protein Folding, Unfolding, and Misfolding. In: Encyclopedia of Polymer Science and Technology. John Wiley & Sons Ltd., Chichester, UK.

4. Alonso, J. C., Balsa, D., Cherny, I., Espinosa, M., Francuski, D., Gazit, E., Gerdes, K., Hitchin, E., Martin, M. T., Concepcin, N. Overweg, K. Pellicer, T. Saenger, W. Welfle, H. Welfle, K., & Wells, J. (2003) Bacterial Toxin-Antitoxin Systems as Targets for the Development of Novel Antibiotics. In: Tolmasky, M., & Bonomo, R. A. (Eds.) Resistance to Antibiotics: Enzyme Mediated Mechanisms and Prospects for Inhibition. The American Society for Microbiology (pp. 313-329). ISBN 1-55581-303-8.

5. Gazit. E. (2005) Novel Antibacterial Drug Candidates based on Toxin-Antitoxin Modules. In: Ingemansson, K. T. & Knezevic, M. (Eds.). EUR 20602 – 100 Technology Offers Stemming from EU Biotechnology RTD Results. Office of the European Commission. ISBN 92-894-4812-1 (pp. 246-248).

6. Gazit, E. (2007) Self-Assembly of Short Peptides for Nanotechnological Applications. In: Shoseyov, O., & Levy, I. (Eds.) NanoBioTechnology: BioInspired Device and Materials of the Future. Humana Press, Totowa NJ, USA. (pp. 385-395). ISBN 1-58829-894-9.

7. Reches, M. & Gazit, E. (2007) Peptide Nanomaterials: Self-Assembling Peptides as Building Blocks for Novel Materials. In: Rao, C.N.R., Mueller, A., & Cheetham, A.K. (Eds.) Nanomaterials Chemistry: Novel aspects and New Directions. Wiley-VCH, Weinheim, Germany (pp. 171-183). ISBN 3-5273-1664-7.

8. Gilead, S., & Gazit, E. (2007) The Role of Aromatic Interactions in Folding, Stability, and Molecular Recognition of Proteins and Polypeptides. In: Uversky, V. N. & Permyakov, E.A. (Eds.). Protein Structures: Methods in Protein Structure and Stability Analysis. Nova Science Publishers, Hauppauge NY, USA. (pp. 363-374) ISBN: 1-60021-705-2

9. Gazit E. (2009) Self-Assembly of Short Aromatic Peptides: Form Amyloid Fobrils Formation to Nanotechnology. In: Shacham-Diamand, Y., Ohba, I., Osaka, T., & Datta, M. (Eds.) Advanced Nanoscale ULSI Interconnects: Fundamentals and Applications. Springer- SBM Ltd., Berlin, Germany (pp. 531-537). ISBN: 978-0-387-95868-2

10. Chakraborty, P., Adler-Abramovich L., & Gazit, E. (2020) Short Peptide Hydrogels for Biomedical Applications. In: Pires, R. A., Reis, R. L, & Pashkuleva, I (Eds.). Multifunctional Hydrogels for Biomedical Applications. Wiley-VCH, Weinheim, Germany (in press).

C. ARTICLES

1. Rapaport, D., Danin, M., Gazit, E. & Shai, Y. (1992) Membrane Interactions of the Sodium Channel S4 Fragment and Its Fluorescently-Labelled Analogues. Biochemistry 31, 8868-8875.

2. Gazit, E. & Shai, Y. (1993) Structural and Functional Characterization of the Alpha-5 Segment of Bacillus thuringiensis delta-Endotoxin. Biochemistry 32, 3429-3436.

3. Gazit, E. & Shai, Y. (1993) Structural Characterization, Membrane Interaction, and Specific Assembly within Phospholipid Membranes of Hydrophobic Segments from Bacillus thuringiensis var. israelensis Cytolytic Toxin. Biochemistry 32, 12363-12371.

4. Gazit, E., Bach, D., Kerr, I. D., Sansom, M. S. P., Chejanovsky, N. & Shai, Y. (1994) The alpha-5 Segment of Bacillus thuringiensis delta-Endotoxin: In-Vitro Activity, Ion Channel Formation and Molecular Modelling. Biochem. J. 304, 895-902.

5. Gazit, E., Lee, W.-J., Brey, P. T. & Shai, Y. (1994) Mode of Action of the Antibacterial Cecropin B2: A Spectrofluorometric Study. Biochemistry 33, 10681-10692.

6. Gazit, E. & Shai, Y. (1995) The Assembly and Organization of the Alpha-5 and Alpha-7 Helices from the Pore-forming Domain of Bacillus thuringiensis delta-Endotoxin: Relevance to a Functional Model. J. Biol. Chem. 270, 2571-2578.

7. Gazit, E., Boman, A., Boman, H. G. & Shai, Y. (1995) Interaction of the Mammalian Antibacterial Peptide Cecropin P1 with Phospholipid Vesicles. Biochemistry 34, 11479-11488.

8. Gazit, E., Miller, I. R., Bigin, P., Sansom, M. S. P. & Shai, Y. (1996) Structure and Orientation of the Mammalian Antibacterial Peptide Cecropin P1 within Phospholipid Membranes. J. Mol. Biol. 258, 860-870.

9. Gazit, E., Burshtein, N., Ellar, D. J., Saywer, T. & Shai, Y. (1997) Bacillus thuringiensis Cytolytic Toxin Associates Specifically with its Synthetic Helices A and C in the Membrane Bound State - Implications for the Assembly of Oligomeric Transmembrane Pores. Biochemistry 36, 15546-15554.

10. Gazit, E., La Rocca, P., Sansom, M. S. P. & Shai, Y. (1998) The Structure and Organization within the Membrane of the Helices Composing the Pore-Forming Domain of Bacillus thuringiensis delta-Endotoxin are Consistent with an “Umbrella-like” Structure of the Toxin Pores. Proc. Natl. Acad. Sci. USA 95, 12289-12294.

11. Gazit, E. & Sauer, R. T. (1999) Stability and DNA Binding of the Phd Protein of Phage P1 Plasmid Addiction System. J. Biol. Chem. 274, 2652-2657.

12. Gazit, E. & Sauer, R. T. (1999) The Doc Toxin and Phd Antidote Proteins of the Bacteriophage P1 Plasmid Addiction System Form a Heterotrimeric Complex. J. Biol. Chem. 274, 16813-16818.

13. Azriel, R. & Gazit, E. (2001) Analysis of the Minimal Amyloid-forming Fragment of the Islet Amyloid Polypeptide. J. Biol. Chem. 276, 34156-34161.

14. Gazit, E. (2002) The “Correctly-Folded” State of Proteins: Is it a Metastable State? Angew. Chem. Int. Ed. Engl. 41, 257-259.

14a. Gazit E. (2002) "Korrekt gefaltete" Protein - ein metastabiler Zustand? Angew. Chem. 114, 267-269 [German version of 14].

15. Gazit, E. (2002) A Possible Role for p-Stacking in the Self-Assembly of Amyloid Fibrils. FASEB J. 16, 77-83.

16. Gazit, E. (2002) Global Analysis of Tandem Aromatic Octapeptide Repeats: The Significance of the Aromatic-Glycine Motif. Bioinformatics 18, 880-883.

17. Gazit, E. (2002) Mechanistic Studies of the Process of Amyloid Fibrils Formation by the use of Peptide Fragments and Analogues: Implications for the Design of Fibrillization Inhibitors. Curr. Med. Chem. 9, 1725-1735.

18. Reches, M., Porat, Y. & Gazit, E. (2002) Amyloid Fibrils Formation by Pentapeptide and Tetrapeptide Fragments of Human Calcitonin. J. Biol. Chem. 277, 35475-35480.

19. Mazor, Y., Gilead, S., Benhar, I. & Gazit, E. (2002) Identification and Characterization of a Novel Molecular-Recognition and Self-Assembly Domain within the Islet Amyloid Polypeptide. J. Mol. Biol. 322, 1013-1024.

20. Gur, E., Biran, D., Gazit, E. & Ron, E. Z. (2002) In vivo Aggregation of a Single Enzyme Limits Growth of Escherichia coli at Elevated Temperatures. Mol. Microbiol. 46, 1391-1397.

21. Reches, M. & Gazit, E. (2003) Casting Metal Nanowires within Discrete Self-Assembled Peptide Nanotubes. Science 300, 625-627.

22. Porat, Y., Stepensky, A., Ding, F-X, Naider, F. & Gazit, E. (2003) Completely Different Amyloidogenic Potential of Nearly Identical Peptide Fragments. Biopolymers 69, 161-164.

23. Porat, Y., Kolusheva, S., Jelinek, R. & Gazit, E. (2003) The Human Islet Amyloid Polypeptide Forms Transient Membrane-Active Prefibrillar Assemblies. Biochemistry 42, 10971-10977. (Featured in a press release prepared by the American Chemical Society).

24. Zanuy, D., Porat, Y., Gazit, E. & Nussinov, R. (2004) Peptide Sequence and Amyloid Formation; Molecular Simulations and Experimental Study of a Human Islet Amyloid Polypeptide Fragment and its Analogs. Structure 12, 439-455.

25. Cherny I. & Gazit, E. (2004) The YefM Antitoxin Defines a Family of Natively Unfolded Proteins: Implications as a Novel Antibacterial Target. J. Biol. Chem. 279, 8252-8261.

26. Reches, M. & Gazit, E. (2004) Formation of Closed-Cage Nanostructures by Self-Assembly of Aromatic Dipeptides. Nano Lett. 4, 581-585.

27. Avisar, D., Keller, M., Gazit, E., Prudovsky, E., Sneh, B. & Zilberstein, A. (2004) The Role of Bacillus thuringiensis Cry1C and Cry1E Separate Structural Domains in the Interaction with Spodoptera littoralis Gut Epithelial Cells. J. Biol. Chem. 279, 15779-15786.

28. Sutovsky, H. & Gazit, E. (2004) The Von Hippel-Lindau Tumor Suppressor Protein is Molten Globule under Native Conditions: Implications for its Physiological Activities. J. Biol. Chem. 279, 17190-17196.

29. Reches, M. & Gazit, E. (2004) Amyloidogenic Hexapeptide Fragment of Medin: Homology to Functional Islet Amyloid Polypeptide Fragments. Amyloid 11, 81-89.

30. Gilead, S. & Gazit, E. (2004) Inhibition of Amyloid Fibril Formation by Peptide Analogues Modified with alpha-Aminoisobutyric Acid. Angew. Chem. Int. Edit. 43, 4041-4044. (Selected as a "Hot Paper: and featured in press-release prepared by Wiley-VCH).

31. Porat, Y., Mazor, Y., Efrat, S. & Gazit, E. (2004) Inhibition of Islet Amyloid Polypeptide Fibril Formation: A Potential Role for Heteroaromatic Interactions. Biochemistry 43, 14454-14462.

32. Gazit, E. (2004) The Role of Prefibrillar Assemblies in the Pathogenesis of Amyloid Diseases. Drugs Fut. 29, 613-619.

33. Gazit, E. (2005) Arrest of Amyloid Fibril Formation Associated to Type II Diabetes: Structural and Functional Links to the Mechanism of Alzheimer’s b-Amyloid Fibrillization. Drug. Design. Rev. 2, 115-119.

34. Gilead, S. & Gazit, E. (2005) Self-Organization of Short Peptide Fragments: From Amyloid Fibrils to Nanoscale Supramolecular

Assemblies. Supramol. Chem. 17, 87-92.

35. Yemini, M., Reches, M., Rishpon, J. & Gazit, E. (2005) Novel Electrochemical Biosensing Platform Using Self-Assembled Peptide Nanotubes. Nano Lett. 5, 183-186. (Featured in an editorial report: Anal. Chem. (2005) 77, 47A).

36. Colombo, G., Daidone, I., Gazit, E., Amadei, A. & Di Nola, A. (2005) Molecular Dynamics Simulation of the Aggregation of the Core Recognition Motif of the Islet Amyloid Polypeptide in Explicit Water. Proteins 59, 519-527.

37. Carny, O. & Gazit, E. (2005) A Model for the Role of Short Self-Assembled Peptides in the very Early Stages of the Origin of Life. FASEB J. 19, 1051-1055.

38. Reches, M. & Gazit, E. (2005) Self-assembly of Peptide Nanotubes and Amyloid-Like Structures by Charged-Termini Capped Diphenylalanine Peptide Analogues. Israel J. Chem. 45, 363-371.

39. Tsai, H-H., Reches, M., Tsai, C-J., Gunasekaran, K., Gazit, E. & Nussinov, R. (2005) Energy Landscape of Amyloidogenic Peptide Oligomerization by Parallel-tempering Molecular Dynamics Simulation: Significant Role of Asn Ladder. Proc. Natl. Acad. Sci. USA 102, 8174-8179.

40. Kol, N., Adler-Abramovich, L., Barlam, D., Shneck, R. Z., Gazit E. & Rousso, I. (2005) Self-Assembled Peptide Nanotubes are Uniquely Rigid Bioinspired Supramolecular Structures. Nano Lett. 5, 1343-1346.

41. Yemini, M., Reches, M., Gazit, E. & Rishpon, J. (2005) Peptide Nanotubes Modified Electrodes for Enzyme-Biosensors Applications. Anal. Chem. 77, 5155-5159.

42. Cherny, I., Rockah, L. & Gazit, E. (2005) The YoeB Toxin is a Folded Protein that Forms a Physical Complex with the Unfolded YefM Antitoxin: Implications for a Structural-based Differential Stability of Toxin-antitoxin Systems. J. Biol. Chem. 280, 30063-30072.

43. Cherny, I., Rockah, L. Levy-Nissenbaum, O., Gophna, U., Ron, E. Z. & Gazit, E. (2005) The Formation of Escherichia coli Curli Amyloid Fibrils is Mediated by Prion-like Peptide Repeats. J. Mol. Biol. 352, 245-252.

44. Motta, A., Reches, M., Pappalardo, L., Andreotti, G. & Gazit, E. (2005) The Preferred Conformation of the Tripeptide Ala-Phe-Ala in Water is an Inverse Gamma-turn: Implications for Protein Folding and Drug Design. Biochemistry 44, 14170-14178.

45. Gazit, E. (2005) Mechanisms of Amyloid Fibril Self-Assembly and Inhibition: Model Short Peptides as a Key Research Tool. FEBS J. 272, 5971-5978.

46. Reches, M. & Gazit, E. (2006) Molecular Self-Assembly of Peptide Nanostructures: Mechanism of Association and Potential Uses. Curr. Nanoscience 2, 105-111.

47. Gazit, E. (2005) Dalle Sofferenze del Morbo di Alzheimer alle Meraviglie delle Nanotecnologie (From the Misery of Alzheimer's Disease to the Wonders of Nanotechnology), KOS, Milan, Italy. 225, 62-64 (in Italian).

48. Adler-Abramovich, L., Reches, M., Sedman, V. L., Allen, S., Tendler, S. J. B. & Gazit, E. (2006) Thermal and Chemical Stability of Diphenylalanine Peptide Nanotubes: Implications for Nanotechnological Applications. Langmuir 22, 1313-1320.

49. Gazit, E. (2006) Nanoscience and Nanotechnology as Research and Development Tools for Biology and Medicine. Nanomedicine 1, 135-137.

50. Gazit, E. (2006) Special Issue on Supramolecular Biochemical Assemblies. Supramol. Chem.18, 387-388.

51. Gazit, E. & Tendler, S. J. B. (2006) Analytical Techniques: Piecing together Biomolecular Self-Assembly. Curr. Opin. Chem. Biol. 10, 385-386.

52. Porat, Y., Abramowitz, A. & Gazit, E. (2006) Inhibition of Amyloid Fibril Formation by Polyphenols: Structural Similarity and Aromatic Interactions as a Common Inhibition Mechanism. Chem. Biol. Drug Des. 67, 27-37.

53. Cohen, T., Frydman-Marom, A., Rechter, M. & Gazit, E. (2006) Inhibition of Amyloid Fibril Formation and Cytotoxicity by Hydroxy-Indole Derivatives. Biochemistry 45, 4727-4735.

54. Gazit, E. (2006) From Green Bacteria to Human Dementia: Novel Models for the Discovery of Amyloid Assembly Inhibitors. ACS Chem. Biol. 1, 417-419.

55. Mahler, A., Reches, M., Rechter, M., Cohen, S. & Gazit, E. (2006). Rigid, Self-Assembled Hydrogel Composed of a Modified Aromatic Dipeptide. Adv. Mater. 18, 1365-1370.

56. Reches, M. & Gazit, E. (2006) Designed Aromatic Homo-Dipeptides: Formation of Ordered Nanostructures and Potential Nanotechnological Applications. Phys. Biol. 3, S10-S19.

57. Sedman, V.L., Adler-Abramovich, L., Allen, S., Gazit, E. & Tendler, S. J. B. (2006) Direct Observation of the Release of Phenylalanine from Diphenylalanine Nanotubes. J. Am. Chem. Soc. 128, 6903-6908.

58. Avidan-Shpalter, C. & Gazit, E. (2006) The Early Stages of Amyloid Formation: Biophysical and Structural Characterization of Calcitonin Pre-fibrillar Assemblies. Amyloid 13, 216-225.

59. Gilead, S., Wolfenson, H. & Gazit, E. (2006) Molecular Mapping of the Recognition Interface between the Islet Amyloid Polypeptide and Insulin. Angew. Chem. Int. Ed. Engl. 45, 6476-6480.

60. Carny, O., Shalev, D. & Gazit, E. (2006) Fabrication of Coaxial Metal Nanowires Using Self-Assembled Peptide Nanotube Scaffold. Nano Lett. 6, 1594-1597.

61. Reches, M. & Gazit, E. (2006) Controlled Patterning of Aligned Self-Assembled Peptide Nanotubes. Nature Nanotech. 1, 195-200. (Featured in

a "News and Views" article: Zhang, S. (2006) Another Break in the Wall. Nature Nanotech. 1, 169-170)

62. Levy, M. Garmy, N., Gazit, E. & Fantini, J. (2006) The Minimal Amyloid-Forming Fragment of the Islet Amyloid Polypeptide is a Glycolipid-Binding Domain. FEBS J. 273, 5724-5735.

63. Gazit E. (2007) Use of biomolecular templates for the fabrication of metal nanowires. FEBS J. 274, 317-322.

64. Nieto, C., Cherny, I., Khoo, S. K., de Lacoba, M. G., Chan, W. T., Yeo, C. C., Gazit, E. & Espinosa, M. (2007) The YefM-YoeB Toxin-Antitoxin Systems of Escherichia coli and Streptococcus pneumoniae: Functional and Structural Correlation. J. Bact. 189, 1266-1278.

65. Gazit, E., della Bruna, P., Pieraccini S. & Colombo, G. (2007) The Molecular Dynamics of Assembly of the Ubiquitous Aortic Medial Amyloidal Medin Fragment. J. Mol. Graph. Model. 25, 903-911.

66. Ghosh, S., Reches, M., Gazit, E. & Verma, S. (2007) Bioinspired Design of Nanocages by Self-Assembling Triskelion Peptide Elements. Angew. Chem. Int. Ed. Engl. 46, 2002-2004.

67. Gazit, E. (2007) Self Assembly of Short Aromatic Peptides into Amyloid Fibrils and Related Nanostructures. Prion 1, 32-35.

68. Shoval, H., Lichtenberg, D. & Gazit, E. (2007) The Molecular Mechanisms of the Anti-amyloid Effects of Phenols. Amyloid 14, 73-87.

69. Reches, M. & Gazit, E. (2007) Biological and Chemical Decoration of Peptide Nanostructures via Biotin-Avidin Interaction. J. Nanosci. Nanotechnol. 7, 2239-2245.

70. Colmbo, G., Soto, P. & Gazit, E. (2007) Peptide Self-assembly at the Nanoscale: A Challenging Target for Computational and Experimental Biotechnology. Trends Biotechnol. 25, 211-218.

71. Adler-Abramovich, L., Perry, R., Sagi, A., Gazit, E. & Shabat, D. (2007) Controlled Assembly of Peptide Nanotubes Triggered by Enzymatic Activation of Self-Immolative Dendrimers. ChemBioChem 8, 859-862.

72. Gazit, E. (2007) Use of Biomolecular Templates for the Fabrication of Metal Nanowires. FEBS J. 274, 317-322.

73. Gazit, E. (2007) Self-Assembled Peptide Nanostructures: The Design of Molecular Building Blocks and their Technological Utilization. Chem. Soc. Rev. 36, 1263-1269.

74. Hendler, N., Sidelman, N., Reches, M., Gazit, E., Rosenberg, Y. & Richter, S. (2007) Formation of Well-Organized Self-Assembled Films

from Peptide Nanotubes. Adv. Mater. 11, 1485-1488.

75. Hill, R. J. A., Sedman, V. L., Allen, S., Williams, P., Paoli, M., Adler-Abramovich, L., Gazit, E., Eaves, L. & Tendler, S. J. B. (2007) Alignment of Aromatic Peptide Tubes in Strong Magnetic Fields. Adv. Mater. 19, 4474-4479.

76. Cherny, I., Overgaard, M., Borch, J., Bram, Y., Gerdes, K. & Gazit, E. (2007) Structural and Thermodynamic Characterization of the Escherichia Coli RelBE Toxin-Antitoxin System: Indication for Functional Role of Differential Stability. Biochemistry 43, 12152-12163.

77. Sopher, N. B., Abrams Z. R., Reches, M., Gazit, E. & Hanein, Y. (2007) Integrating Peptide Nanotubes in Micro-Fabrication Processes. J. Micromech. Microeng. 11, 2360-2365.

78. Cherny I. & Gazit, E. (2008) Amyloids: Not Only Pathological Agents but Also Ordered Nanomaterials. Angew. Chem. Int. Ed. Engl. 47, 4062-4069.

78a. Cherny I. & Gazit, E. (2008) Amyloide: nicht nur pathologische Substanzen, sondern auch geordnete Nanomaterialien. Angew. Chem. 22, 4128–4136 [German version of 78].

79. Gazit, E. & Nussinov, R. (2008). Nanostructure Design: Methods and Protocols. Methods Mol. Biol. 474, 5-12.

80. Adler-Abramovich, L. & Gazit, E. (2008) Controlled Pattering of Peptide Nanotubes and Nanospheres Using Inkjet Printing Technology. J. Pep. Sci. 14, 217-223.

81. Soreq H. & Gazit, E. (2008) The Structural Basis of Amyloid Formation. Curr. Alzheimer Res. 5, 232.

82. Levy, M., Porat Y., Bachrach, E., Shalev, D.E. & Gazit, E. (2008) Phenolsulfonphthalein, but not Phenolphthalein, Inhibits Amyloid Fibril Formation: Implications for the Modulation of Amyloid Self - assembly. Biochemistry 47, 5896-5904.

83. Gazit, E. (2008) Molecular Self-Assembly: Bioactive Nanostructures Branch Out. Nature Nanotech. 3, 8-9.

84. Adler-Abramovich, L., Aronov, D., Gazit, E. & Rosenman, G. (2008) Patterned Arrays of Ordered Peptide Nanostructures. J. Nanosci. Nanotech. 9, 1701-1708.

85. Gilead, S. & Gazit, E. (2008) The Role of the 14-20 Domain of the Islet Amyloid Polypeptide in Amyloid Formation. Exp. Diabet. Res. 2008: 256954.

86. Shoval, H., Weiner, L., Gazit, E., Levy, M., Pinchuk, I. & Lichtenberg, D. (2008) Polyphenol-Induced Dissociation of Various Amyloid Fibrils Results in a Methionine-Independent Formation of ROS. Biochim. Biophys. Acta. 1784, 1570-1577.

87. Rambold, A. S., Miesbauer, M., Olschewski, D., Seidel, R., Riemer, C., Smale, L., Brumm, L., Levy, M., Gazit, E., Oesterhelt, D., Baier, M., Becker, C. F. W., Engelhard, M., Winklhofer, K. F. & Tatzelt, J. (2008) Green Tea Extracts Interfere with the Stress-Protective Activity of PrPC and the Formation of PrPSc. J. Neurochem. 107, 218-229.

88. Garcia-Pino, A., Dao-Thi, M. H., Gazit, E., Magnuson, R. D., Wyns, L. & Loris, R. (2008) Crystallization of Doc and the Doc:Phd Toxin-Antitoxin Complex. Acta Crystallogr. Sect. F. 64, 1034-1038.

89. Gazit, E. & Nussinov, R. (2008) Nanostructures Design: Methods and Protocols. Preface. Method Mol. Biol. 474, 5-7.

90. Kasotakis, E., Mossou, E., Adler-Abramovich, L., Mitchell, E. P., Forsyth, V.T., Gazit, E. & Mitraki, A. (2009) Design of Metal-Binding Sites onto Self-Assembled Peptide Fibrils. Biopolymers 92, 164-172.

91. Frydman-Marom, A. Rechter, M. Shefler, I., Bram, Y., Shalev, D. E. & Gazit, E. (2009) Cognitive Performance Recovery of Alzheimer's Disease Model Mice by Modulating Early Soluble Amyloidal Assemblies. Angew. Chem. Int. Ed. Engl. 48, 1981-1986.

92. Tamamis P., Adler-Abramovich, L., Reches, M., Marchakk, K., Sikorski, P., Serpell, L., Gazit, E. & Archontis, G. (2009) Self-Assembly of Phenylalanine Oligopeptides: Insights from Experiments and Simulations. Biophys. J. 96, 5020-5029.

93. Amdursky, N., Molotskii, M., Aronov, D., Adler-Abramovich, L., Gazit, E. & Rosenman, G. (2009) Blue Luminescence Based on Quantum Confinement at Peptide Nanotubes. Nano Lett. 9, 3111-3115.

94. Orbach, R., Adler-Abramovich, L., Zigerson, S., Mironi-Harpaz, I., Seliktar, D. & Gazit, E. (2009) Self-Assembled Fmoc-Peptides as a Platform for the Formation of Nanostructures and Hydrogels. Biomacromolecules 10, 2646-2651.

95. Levy-Sakin, M., Shreberk, M., Daniel, Y. & Gazit, E. (2009) Targeting Insulin Amyloid Assembly by Small Aromatic Molecules: Toward Rational Design of Aggregation Inhibitors. Islet 1, 210-215.

96. Adler-Abramovich, L., Aronov, D., Beker, P., Yevnin, M., Stempler, S., Buzhansky, L., Rosenman, G. & Gazit, E. (2009) Self-Assembled Arrays of Peptide Nanotubes by Vapour Deposition. Nature Nanotech. 4, 849-854.

97. Amdursky, N., Orbach, R., Gazit, E. & Huppert, D. (2009) Probing the Inner Cavities of Hydrogels by Proton Diffusion. J. Phys. Chem. 45, 19500-19505.

98. Amdursky, N., Molotskii, M., Gazit, E. & Rosenman G. (2009) Self-Assembled Bioinspired Quantum Dots: Optical Properties. Appl. Phys. Lett. 94, 261907.

99. Mostaert, A. S., Crockett, R., Kearn, G., Cherny, I., Gazit, E., Serpell, L. C. & Jarvis, S. P. (2009) Mechanically Functional Amyloid Fibrils in the Adhesive of a Marine Invertabrates as Revealed by Raman Spectroscopy and Atomic Force Microscopy. Arch. Histol. Cytol. 72, 199-207.

100. Scherzer-Attali, R., Pellarin, R., Convertino, M., Frydman-Marom, A., Levy-Sakin, M., Shalev, D. E., Caflisch, A., Gazit, E. & Segal, D. (2010) Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor. PLoS One 5, e11101.

101. Adler-Abramovich, L., Badihi-Mossberg, M., Gazit, E. & Rishpon, J. (2010) Charachterization if Peptide Nanostructures Modified Electrodes and their Application for Ultra- Sensitive Enviromental Monitoring. Small 7, 825-831.

102. Kholkin, A., Amdursky, N., Bdikin, I., Gazit, E. & Rosenman, G. (2010) Strong Piezoelectricity in Bioinspired Peptide Nanotubes. ACS Nano. 2, 610-614.

103. Ostrov, N. & Gazit, E. (2010) Genetic Engineering of Biomolecular Scaffolds for the Fabrication of Organic and Metalic Nano-Wires. Angew. Chem. Int. Ed. Engl. 17, 3018-3021 [Featured in News and Views at Nature Chem. 2, 521-523].

104. Garcia-Pino, A., Balasubramanian, S., Wyns, L., Gazit, E., De Greve, H., Magnuson, RD., Charlier, D., van Nuland, N.A. & Loris, R. (2010) Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity. Cell 142, 101-111.

105. Shklovsky, J. Beker, P., Amdursky, N., Gazit, E. & Rosenman, G. (2010) Bioinspired Peptide Nanotubes: Deposition Technology and Physical Properties. Mater. Sci. Eng. B 169, 62-66.

106. Amdursky, N., Gazit, E. & Rosenman, G. (2010) Quantum Confinement in Self-Assembled Bioinspired Peptide Hydrogels. Adv. Mater. 22, 2311-2315.

107. Gazit E. (2010) Bioinspired Chemistry: Diversity for Self-Assembly (News and Views) Nature Chem. 2, 1010-1011.

108. Adler-Abramovich, L., Kol, N., Yanai, I., Barlam, D., Shneck, R. Z., Gazit, E. & Rousso, I. (2010) Self-Assembled Organic Nanostructures with Metallic-Like Stiffness. Angew. Chem. Int. Ed. Engl. 49, 9939-9942.

109. Amdursky, N., Beker, P., Schklovsky, J., Gazit, E. & Rosenman, G. (2010) Ferroelectric and Related Phenomena in Biological and Bioinspired Nanostructures. Ferroelectrics 399, 107-117.

110. Amdursky, N., Molotskii, M., Gazit, E. & Rosenman, G. (2010) Elementary Building Blocks of Self-assembled Peptide Nanotubes. J. Am. Chem. Soc. 132, 15632-1566. (Featured in News and Views in Nature).

111. Shaltiel-Karyo, R., Frenkel-Pinter, M., Egoz-Matia, N., Frydman-Marom, A., Shalev, D.E., Segal, D. & Gazit, E. (2010) Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies. PLoS One 5, e13863.

112. Beker, P., Koren, I., Amdursky, N., Gazit, E. & Roseman, G. (2010) Bioinspried Nanotubes as Supercapacitor Electrodes. J. Mater. Sci. 45, 6374-6378.

113. Carny, O. & Gazit, E. (2011) Creating Prebiotic Sanctuary: Self-Assembling Supramolecular Peptide Structures Bind and Stabilize RNA. Orig. Life Evol. Biosph. 41, 121-132.

114. Stempler, S., Levy-Sakin, M, Frydman-Marom, A., Amir, Y., Scherzer-Attali, R., Buzhansky, L., Gazit, E. & Senderowitz, H. (2011) Quantitative Structure-Activity Relationship Analysis of b-Amyloid Aggregation Inhibitors. J. Comput. Aided Mol. Des. 25, 135-144.

115. Even, N, Adler-Abramovich, L., Buzhansky, L., Dudiuk, H. & Gazit, E. (2011) Peptide Nanotubes as a Unique Organic Nanofiller Improves the Mechanical Properties of Epoxy. Small 7, 1007-1011.

116. Andreotti, G., Vitale, R.M., Avidan-Shpalter, C., Amodeo, P., Gazit, E. & Motta, A. (2011) Converting the Highly Amyloidogenic Human Calcitonin into a Powerful Fibril Inhibitor by 3D Structure Homology with a Non-Amyloidogenic Analogue. J. Biol. Chem. 286, 2707-2718.

117. Frydman-Marom, A., Shaltiel-Karyo, R., Moshe, S. & Gazit E. (2011) The Generic Amyloid Formation Inhibition Effect of a Designed Small Aromatic β-Breaking Peptide. Amyloid 18, 119-127.

118. Frydman-Marom, A., Levin, A., Farfara, D., Benromano, T., Scherzer-Attali, R., Peled, S., Vassar, R., Segal, D., Gazit, E., Frenkel, D. & Ovadia, M. (2011) Orally Administrated Cinnamon Extract Reduces β-amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer's Disease Animal Models. PLoS One 6, e16564.

119. Amdursky, N., Beker, P., Koren, I., Bank-Srour, B., Mishina, E., Semin, S., Rasing, T., Rosenberg, Y., Barkay, Z., Gazit, E. & Rosenman, G. (2011) Structural Transition in Peptide Nanotubes. Biomacromolecules 12, 1349-1354.

120. Roytman, R., Adler-Abramovich, L., Kumar, K.S., Kuan, T.C., Lin, C.C., Gazit, E. & Brik, A. (2011) Exploring the Self-Assembly of Glycopeptides using a Diphenylalanine Scaffold. Org. Biomol. Chem. 9, 5755-5761.

121. Frydman-Marom, A., Convertino, M., Pellarin, R., Lampel, A., Shaltiel-Karyo, R., Segal, D., Caflisch, A., Shalev, D.E. & Gazit E. (2011) Structural Basis for Inhibiting β-Amyloid Oligomerization by a Non-coded β-Breaker-Substituted Endomorphin Analogue.

ACS Chem. Biol. 6, 1265-1276.

122. Santhanamoorthi, N., Kolandaivel, P., Adler-Abramovich, L., Gazit, E., Filipek, S., Viswanathan, S., Strzelczyk, A. & Renugopalakrishnan, V. (2011) Diphenylalanine Peptide Nanotube: Charge Transport, Band Gap and its Relevance to Potential Biomedical Applications. Adv. Mat. Lett. 2, 100-105.

123. Frydman-Marom, A., Scherzer-Attali, R., Shaltiel-Karyo, R. & Gazit, E. (2012) Amyloid Peptides: Solution Structure Studies on Aggregative Peptides. Biopolymers 96, 506-507.

124. Goldshtein, K., Golodnitsky, D., Peled, E., Adler-Abramovich, L., Gazit, E., Khatun, S., Stallworth, S. & Greenbaum, P. (2012) Effect of Peptide Nanotube Filler on Structural and Ion-Transport Properties of Solid Polymer Electrolytes. Solid State Ionics 220, 39-46.

125. Shaltiel-Karyo, R., Davidi, D., Menuchin, Y., Frenkel-Pinter, M., Marcus-Kalish, M., Ringo, J., Gazit, E. & Segal, D. (2012) A Novel, Sensitive Assay for Behavioral Defects in Parkinson's Disease Model Drosophila. Parkinsons Dis. 2012, 697564.

126. Shaltiel-Karyo, R., Davidi, D., Frenkel-Pinter, M., Ovadia, M., Segal, D. & Gazit, E. (2012)

Differential Inhibition of α-Synuclein Oligomeric and Fibrillar Assembly in Parkinson's Disease Model by Cinnamon Extract. Biochim. Biophys. Acta. 1820, 1628-1635.

127. Scherzer-Attali, R., Shaltiel-Karyo, R., Adalist, Y.H., Segal, D. & Gazit, E. (2012) Generic Inhibition of Amyloidogenic Proteins by Two Naphthoquinone-Tryptophan Hybrid Molecules. Proteins 80, 1962-1973.

128. Scherzer-Attali, R., Farfara, D., Cooper, I., Levin, A., Ben-Romano, T., Trudler, D., Vientrov, M., Shaltiel-Karyo, R., Shalev, D.E., Segev-Amzaleg, N., Gazit, E., Segal, D. & Frenkel, D. (2012) Naphthoquinone-Tyrptophan Reduces Neurotoxic Aβ*56 Levels and Improves Cognition in Alzheimer's Disease Animal Model. Neurobiol. Dis. 46, 663-672.

129. Amdursky, N., Koren, I., Gazit, E. & Rosenman, G. (2012) Adjustable Photoluminescence of Peptide Nanotubes Coatings. J. Nanosci. Nanotechnol. 11, 9282-9286.

130. Amdursky, N., Gazit, E. & Rosenman G. (2012) Formation of Low-Dimensional Crystalline Nucleus Region During Insulin Amyloidogenesis Process. Biochem. Biophys. Res. Commun. 419, 232-237.

131. Orbach, R., Mironi-Harpaz, I., Adler-Abramovich, L., Mossou, E., Mitchell, E.P., Forsyth, V.T., Gazit, E. & Seliktar, D. (2012) The Rheological and Structural Properties of Fmoc-Peptide-Based Hydrogels: The Effect of Aromatic Molecular Architecture on Self-Assembly and Physical Characteristics. Langmuir 28, 2015-2022.

132. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Frenkel, D. & Gazit, E. (2012) Phenylalanine Assembly into Toxic Fibrils Suggests Amyloid Etiology in Phenylketonuria. Nature Chem. Biol. 8, 701-706.

133. Herzog, G., Joerger, A.C., Shmueli, M.D., Fersht, A.R., Gazit, E. & Segal, D. (2012) Evaluating Drosophila p53 as a Model System for Studying Cancer Mutations. J. Biol. Chem. 287, 44330-44337.

134. Scherzer-Attali, R., Convertino, M., Pellarin. R., Gazit, E., Segal, D. & Caflisch A. (2013)

Methylations of Tryptophan-Modified Naphthoquinone Affect Its Inhibitory Potential toward Aβ Aggregation. J. Phys. Chem. B. 117, 1780-1789.

135. Ghosha, S., Adler-Abramovich, L., Gazit, E. & Verma, S. (2013) Spacer Driven Morphological Twist in Phe-Phe Dipeptide Conjugates. Tetrahedron 69, 2004-2009.

136. Lampel, A., Bram, Y., Levy-Sakin, M., Bacharach, E. & Gazit, E. (2013) The Effect of Chemical Chaperones on the Assembly and Stability of HIV-1 Capsid Protein. PLoS One 8, e60867.

137. Ischakov, R., Buzhansky, L., Adler-Abramovich, L. & Gazit, E. (2013) Peptide-Based Hydrogel Nanoparticles as Effective Drug Delivery Agents. Bioorg. Med. Chem. 21, 3517-3522.

138. Shaltiel-Karyo, R., Frenkel-Pinter, M., Rockenstein, E., Patrick, C., Levy-Sakin, M., Schiller, A., Egoz-Matia, N., Masliah, E., Segal, D. & Gazit, E. (2013) A Blood-Brain Barrier (BBB) Disrupter is also a Potent α-Synuclein (α-Syn) Aggregation Inhibitor: A Novel Dual Mechanism of Mannitol for the Treatment of Parkinson Disease (PD). J. Biol. Chem. 288, 17579-17588.

139. Lampel, A., Yaniv, O., Berger, O., Bacharach, E., Gazit, E. & Frolow, F. (2013) A Triclinic Crystal Structure of the Carboxy-Terminal Domain of HIV-1 Capsid Protein with Four Molecules in the Asymmetric Unit Reveals a Novel Packing Interface. Acta Crystallogr. Sect. F. 69, 602-606.

140. Shmueli, M.D., Schnaider, L., Rosenblum, D., Herzog, G., Gazit, E. & Segal D. (2013)

Structural Insights into the Folding Defects of Oncogenic pVHL Lead to Correction of its Function In Vitro. PLoS One 8, e663337.

141. Davidi, D., Sade, D., Schuchalter, S. & Gazit, E. (2014) High Throughput Assay for Temporal Kinetic Analysis of Lytic Coliphages Activity. Anal. Biochem. 444, 22-24.

142. Fichman, G. & Gazit, E. (2014) Self-Assembly of Short Peptides to Form Hydrogels: Design of Building Blocks, Physical Properties and Technological Applications. Acta Biomater. 10, 1671-1682.

143. Azuri, I., Adler-Abramovich, L., Gazit, E., Hod, O. & Kronik, L. (2014) Why are Diphenylalanine-Based Peptide Nanostructures so Rigid? Insights from First Principles Calculations. J. Am. Chem. Soc. 136, 963-969.

144. Vasudev, M. C., Koerner, H., Singh, K. M., Partlow, B. P., Kaplan, D. L., Gazit, E., Bunning, T. J. & Naik, R. R. (2014). Vertically Aligned Peptide Nanostructures Using Plasma-Enhanced Chemical Vapor Deposition. Biomacromolecules 15, 533-540.

145. Mason, T. O., Chirgadze, D. Y., Levin, A., Adler-Abramovich, L., Gazit, E., Knowles, T. P. & Büll, A. K. (2014) Expanding the Solvent Chemical Space for Self-Assembly of Dipeptide Nanostructures. ACS Nano 8, 1243-1253.

146. Levy-Sakin, M., Berger, O., Feibish, N., Sharon, N., Schnaider, L., Shmul, G., Amir, Y., Buzhansky, L. & Gazit, E. (2014) The Influence of Chemical Chaperones on Enzymatic Activity under Thermal and Chemical Stresses: Common Features and Variation among Diverse Chemical Families. PLoS One 9, e88541.

147. Mossou, E., Teixeira, S. C. M., Mitchell, E.P., Mason, S.A., Adler-Abramovich, L., Gazit, E. & Forsyth, V. T. (2014) Crystal Structure of the Self-Assembling Zwitterionic Form of Phenylalanine at Neutral pH. Acta Crystallogr. Sect. C. 70, 326-331.

148. Bram, Y., Frydman-Marom, A., Yanai, I., Gilead, S., Shaltiel-Karyo, R., Amdursky, A. & Gazit, E. (2014) Apoptosis Induced by Islet Amyloid Polypeptide Soluble Oligomers is Neutralized by Diabetes-Associated Specific Antibodies. Sci. Rep. 4, 4267.

149. Fichman, G., Adler-Abramovich, L., Manohar, S., Mironi-Harpaz, I., Guterman, T., Seliktar, T., Messersmith, P. & Gazit, E. (2014) Seamless Metallic Coating and Surface Adhesion of Self-Assembled Bioinspired Nanostructures Based on Di-(3,4-dihydroxy-l-phenylalanine) Peptide Motif. ACS Nano 8, 7220-7228.

150. Fichman, G., Guterman, T., Adler-Abramovich, L. & Gazit, E. (2014) The Use of the Calcitonin Minimal Recognition Module for the Design of DOPA-Containing Fibrillar Assemblies. Nanomaterials 4, 726-740.

151. Gazit, E. (2014) Controlling Molecular Self-assembly: From Amyloid Oligomerization and Therapy to Novel Biomaterials and Technological Applications.

152. Adler-Abramovich, L. & Gazit, E. (2014) The Physical Properties of Supramolecular Peptide Assemblies: From Building Block Association to Technological Applications. Chem. Soc. Rev. 43, 6881-6893.

153. Shmueli, M. D., Schnaider, L., Herzog, G., Gazit, E. and Segal, D. (2014) Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome. PLoS One 9, e109864.

154. Levin, A. Mason, T. O., Adler-Abramovich, L., Buell, A. K., Meisl, G., Galvagnion, C., Bram, Y., Dobson, C. M., Knowles, T. P. J. & Gazit, E. (2014) Ostwald’s Rule of Stages Governs Structural Transitions and Morphological Control of a Dipeptide Supramolecular Polymer. Nature Commun. 5, 5219.

155. Kaur, G., Adler-Abramovich, L., Gazit, E. & Verma, S. (2014) Ultrastructure of Metallopeptide-Based Soft Spherical Morphologies. RSC Adv. 4, 64457-64465.

156. Ostrov, N. Fichman, G., Adler-Abramovich, L. & Gazit, E. (2015) FtsZ Cytoskeletal Filaments as a Template for Metallic Nanowire Fabrication. J. Nanosci. Nanotechnol. 15, 556-561.

157. Gazit, E. (2015) Molecular Self-Assembly: Searching Sequence Space (News and Views). Nature Chem. 7, 14-15.

159. Berger, O., Adler-Abramovich, L., Levy-Sakin, M., Grunwald, A., Liebes-Peer, Y., Bachar, M., Buzhansky, L., Mossou, E., Forsyth, V.T., , Schwartz, T., Ebenstein, Y., Frolow, F., Shimon, L. J. W., Patolsky, F. & Gazit, E. (2015) Light-Emitting Self-Assembled Peptide Nucleic Acids Exhibit Both Stacking Interactions and Watson-Crick Base Pairing. Nature Nanotech. 10, 353-360 [Featured in News and Views at Nature Nanotech. 10, 295-296 and on the cover of the 10th

anniversary issue of Nature Nanotech. (October 2016 – "A decade of small wonders")].

158. Bram, Y., Lampel, A., Shaltiel-Karyo, R., Ezer, A., Scherzer-Attali, R., Segal D. & Gazit, E. (2015) Monitoring and Targeting the Initial Dimerization Stage of Amyloid Self-Assembly. Angew. Chem. Int. Ed. Engl. 54, 20620-2067 [Featured in Research Highlights at Nature Mater. 14, 134].

160. Arnon, Z., Adler-Abramovich, L., Levin, A., & Gazit, E. (2015) Exploring Molecular Self-Assembly of the Highly Hydrophobic Tetra- and Penta-Phenylalanine Peptides in Aqueous Solutions using Solvent-Switch. Isr. J. Chem. 55, 756-762.

161. Pellach, M., Atsmon-Raz, Y., Simonovsky, E., Gottlieb, H, Adler-Abramovich, L., Miller, Y. & Gazit, E. (2015) Spontaneous Structural Transition in Phospholipid-Inspired Aromatic Phosphopeptide Nanostructures. ACS Nano 9, 4085-4095.

162. Herzog, G., Shmueli, M.D., Levy, L., Engel, L., Gazit, E., Klärner, F.G., Schrader, T., Bitan, G. & Segal D. (2015) The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry 54, 3729-3738.

163. Lampel, A., Elis, E., Guterman, T., Shapira, S., Bacharach, E. & Gazit, E. (2015) α-Aminoisobutyric Acid Incorporation Induces Cell Permeability and Antiviral Activity of HIV-1 Major Homology Region Fragment. Chem. Commun. 51, 12349-12352.

164. Lampel, A., Bram, Y., Ezer, A., Shaltiel-Kario, R., Saad, J.S., Bacharach, E. & Gazit, E. (2015) Targeting the Early Step of Building Block Organization in Viral Capsid Assembly. ACS Chem. Biol. 9, 4085-4095.

165. Shaham-Niv, S., Adler-Abramovich, L., Schnaider L. & Gazit E. (2015) Extension of the Generic Amyloid Hypothesis to Non-Proteinaceous Metabolite Assemblies. Science Adv. 1, e1500137.

166. Fichman, G., Guterman, T., Adler-Abramovich, L. & Gazit, E. (2015) Synergetic Functional Properties in Two-Component Single Amino Acid-Based Hydrogels. CrystEngComm 17, 8105-8112.

167. Lampel, A., Varenik, M., Regev O. & Gazit, E. (2015) Hierarchical Multi-Step Organization during Viral Capsid Assembly. Colloids Surf. B 136, 674-677.

168. Khemtemourian, L., Gazit, E. & Miranker, A. (2015) Recent Insight in Islet Amyloid Polypeptide Morphology, Structure, Membrane Interaction, and Toxicity in Type 2 Diabetes (editorial). J. Diabet. Res. 501, 836364.

169. Tao, K., Yoskovitz, E., Adler-Abramovich, L. & Gazit, E. (2015) Optical Property Modulation of Fmoc Group by pH-Dependent Self-Assembly. RSC Adv. 5, 73914-73918.

170. Mondal, S., Adler-Abramovich, L., Lipman, S. & Gazit E. (2015) Formation of Functional Super-Helical Assemblies by Constrained Single Heptad Repeat. Nature Commun. 6, 8615.

171. De Luigi, A., Mariani, A., De Paola, M., Re Depaolini, A., Colombo, L., Russo, L., Rondelli, V., Brocca, P., Adler-Abramovich, L., Gazit, E., Del Favero, E., Cantù, L. & Salmona, M. (2015) Doxycycline Hinders Phenylalanine Fibril Assemblies Revealing a Potential Novel Therapeutic Approach in Phenylketonuria. Sci. Rep. 5, 15902.

172. Tao, K. Adler-Abramovich, L. & Gazit, E. (2015) Controllable Phase Separation by Boc-Modified Lipophilic Acid as a Multifunctional Extractant. Sci. Rep. 5, 17509.

173. Berger, O., Yoskovitz, E., Adler-Abramovich, L. & Gazit, E. (2016) Spectral Transition in Bio-Inspired Self-Assembled Peptide Nucleic Acid Photonic Crystals. Adv. Mater. 28, 2195-2200.

174. Fichman, G., Guterman, T., Damron, J., Adler-Abramovich, L., Schmidt, J., Kesselman, E., Shimon, L. J. W., Ramamoorthy, A., Talmon, Y. & Gazit, E. (2016) Spontaneous Structural Transition and Crystal Formation in Minimal Supramolecular Polymer Model. Science Adv. 2, e1500827.

175. Levin, A., Michaels, T. C. T., Adler-Abramovich, L., Mason, T. O., Mueller, T., Mahadevan, L., Gazit, E. & Knowles, T. P. J. (2016) Elastic Instability-Mediated Actuation by a Supramolecular Polymer. Nature Physics 12, 926–930.

176. Gazit, E., (2016) Peptide Nanostructures: Aromatic Dipeptides Light Up (News and Views). Nature Nanotech. 11, 309-310.

177. Frenkel-Pinter, M., Tal, S., Scherzer-Attali, R., Abu-Hussien, M., Alyagor, I., Eisenbaum, T., Gazit, E., & Segal, D. (2016) Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity. J. Alzheimers Dis. 51, 165-178.

178. Frenkel-Pinter, M., Richman, M., Belostozky, A., Abu-Mokh, A., Gazit, E., Rahimipour, S., & Segal, D. (2016) Selective Inhibition of Aggregation and Toxicity of a Tau-Derived Peptide using Its Glycosylated Analogues. Chemistry 22, 5945-5452.

179. Tao, K., Levin, A., Adler-Abramovich, L., & Gazit E. (2016) Fmoc-Modified Amino Acids and Short Peptides: Simple Bio-inspired Building Blocks for the Fabrication of Functional Materials. Chem. Soc. Rev. 45, 3935-3953.

180. Felicity, O., Louis, S., Gazit, E., & de Mel, A. (2016) Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System? Curr. Med. Chem. 23, 1625-1637

181. Mondal, S. & Gazit, E. (2016) The Self-Assembly of Helical Peptide Building Blocks. ChemNanoMat 2, 323-332.

182. Gazit, E. (2016) Metabolite Amyloids: A New Paradigm for Inborn Error of Metabolism Disorders. J. Inherit. Metab. Dis. 39, 483-488.

183. Pellach, M., Mondal, S., Shimon, L., Adler-Abramovich, L., Buzhansky, L., & Gazit, E. (2016) Molecular Engineering of Self-Assembling Diphenylalanine Analogues Results in Formation of Distinctive Microstructures. Chem. Mater. 28, 4341-4348.

184. Mason, T.O., Michaels, T., Levin, A., Gazit, E., Dobson, C. M, Buell, A, & Knowles, T.P.J. (2016) Synthesis of Non-Equilibrium Supra-Molecular Peptide Polymers on a Microfluidic Platform. J. Am. Chem. Soc. 138, 9589-9596.

185. Adler-Abramovich, L., Marco, P., Arnon, Z., Creasey, R. C. G., Michaels, T.C.T, Levin, A., Scurr, D.J., Roberts, C.J., Knowles, T. P.J. Tendler, S.J.B., & Gazit, E. (2016) Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly. ACS Nano 8, 7436-7442.

186. Guo, C., Arnon, Z. A., Qi, R., Zhang, Q., Adler-Abramovich, L., Gazit, E. & Wei, G. (2016) Expanding the Nanoarchitectural Diversity through Aromatic Di- and Tri-Peptide coassembly: Nanostructures and Molecular Mechanism. ACS Nano 10, 8316-8324.

187. Malishev, R., Nandi, S., Kolusheva, S., Shaham-Niv, S., Gazit, E. & Jelinek R. (2016) Bacoside-A, An Anti-Amyloid Natural Substance, Inhibits Membrane Disruption by the Amyloidogenic Determinant of Prion Protein Through Accelerating Fibril Formation. Biochim. Biophys. Acta. 1858, 2208-2214.

188. Tao, K., Levin, A., Jacoby, G., Beck, R. & Gazit, E. (2016) Entropic Phase Transitions with Stable Twisted Intermediates of Bio-Inspired Self-Assembly. Chem. Eur. J. 22, 15237-15241.

189. Tao, K., Jacoby, G., Burlaka, L., Beck, R. & Gazit, E. (2016) Design of Controllable Bio-Inspired Chiroptic Self-Assemblies. Biomacromolecules 17, 2937-2945.

190. Creasey, R.C., Louzao, I., Arnon, Z.A., Marco, P., Adler-Abramovich, L., Roberts, C.J., Gazit, E. & Tendler, S.J. (2016) Disruption of Diphenylalanine Assembly by a Boc-Modified Variant. Soft Matter. 12, 9451-9457.

191. Benito, A.B., Aiertza, M.K., Marradi, M., Gil-Iceta, L., Shekther Zahavi, T., Szczupak, B., Jiménez-González, M., Reese, T., Scanziani, E., Passoni, L., Matteoli, M., De Maglie, M., Orenstein, A., Oron-Herman, M., Kostenich, G., Buzhansky, L., Gazit, E., Grande, H.J., Gómez-Vallejo, V., Llop, J. & Loinaz, I. (2016) Functional Single-Chain Polymer Nanoparticles: Targeting and Imaging Pancreatic Tumors In Vivo. Biomacromolecules 17, 3213-3221.

192. Arnon , Z., Vitalis , A., Levin, A., Michaels, T., Caflisch, A., Knowles, T.P.J., Adler-Abramovich, L. & Gazit, E. (2016) Dynamic Microfluidic Control of Supramolecular Peptide Self-Assembly. Nature Commun. 7, 13190.

193. Guterman, T., Kornreich, M., Stern, A., Adler-Abramovich, L., Porath , D., Beck , R., Shimon, L. & Gazit, E. (2016) Formation of Bacterial Pilus-Like Nanofibers by Designed Minimalistic Self-Assembling Peptides. Nature Commun. 7, 13482.

194. Frenkel-Pinter, M., Tal, S., Scherzer-Attali, R., Abu-Hussien, M., Alyagor, I., Eisenbaum, T., Gazit, E. & Segal, D. (2017) Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neurodegener Dis. 17, 73-82.

195. Ben-Nun, Y., Fichman, G., Adler-Abramovich, L., Turk, B., Gazit, E. & Blum, G. (2017) Cathepsin Nanofiber Substrates as Potential Agent for Targeted Drug Delivery. J. Control. Rel. 257, 60-67.

196. Shaham-Niv, S., Rehak, P., Vuković, L., Adler-Abramovich, L., Král, P. & Gazit, E. (2017) Formation of Apoptosis-Inducing Amyloid Fibrils by Tryptophan. Israel J. Chem. 57, 729-737.

197. Mondal, S., Varenik, N., Bloch, D.N., Atsmon-Raz, Y., Adler-Abramovich, L., Shimon, L. J. W., Miller, Y., Regev, O. & Gazit, E. (2017) A Minimal Length Rigid Helical Peptide Motif Allows Rational Design of Modular Surfactants. Nature Commun. 8, 14018.

198. Pellach, M., Mondal, S., Harlos, K., Mance, D., Baldus, M., Gazit, E. & Shimon, L.J. (2017) A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure. Angew. Chem. Int. Ed. Engl. 56, 3252-3255.

199. Malishev, R., Shaham-Niv, S., Nandi, S., Kolusheva, S., Gazit, E. & Jelinek, R. (2017) Bacoside-A, an Indian Traditional-Medicine Substance, Inhibits β-Amyloid Cytotoxicity, Fibrillation, and Membrane Interactions. ACS Chem. Neurosci. 8, 884-891.

200. Schechter, T., Oron-Herman, O., Kostenich, G., Rub, E., Salitra,Y., Buzhansky, L., Orenstein, A., Gazit, E. & Adler-Abramovich, L. (2017) Molecular Engineering of Somatostatin Analogue with Minimal Dipeptide Motif Induces the Formation of Functional Nanoparticles. ChemNanoMat 3, 27–32.

201. Berger, O. & Gazit, E. (2017) Molecular Self-Assembly using Peptide Nucleic Acids. Peptide Science 108, e22930.

202. Peled, S., Sade, S., Bram, Y., Porat, Z., Kreiser, T., Mimouni, M., Lichtenstein, A., Segal, D. & Gazit, E. (2017) Single Cell Imaging and Quantification of TDP-43 and α-Synuclein Intercellular Propagation. Sci. Rep. 7, 544.

203. Brahmachari, S., Paul, A., Segal, D. & Gazit, E. (2017) Inhibition of Amyloid Oligomerization into Different Supramolecular Architectures by Small Molecules: Mechanistic Insights and Design Rules. Future Med. Chem. 9, 797-810.

204. Mason, T. O., Dobson, C. M., Gazit, E., Knowles, T. P. J. & Buell, A. K. (2017) Thermodynamics of Polypeptide Supramolecular Assembly in the Short Chain Limit. J. Am. Chem. Soc. 139, 16134-16142.

205. Tao, K., Xue, B., Frere, S., Slutsky, I., Cao, Y., Wang, W. & Gazit, E. (2017) Multiporous Supramolecular Microspheres for Artificial Photosynthesis. Chem. Mater. 29, 4454-4460.

206. Pujals, S., Tao, K., Terradellas-Igual, A., Gazit, E. & Albertazzi, L. (2017) Studying Structure and Dynamics of Self-Assembled Peptide Nanostructures using Fluorescence and Super Resolution Microscopy. Chem. Comm. 53, 7294-7297.

207. Wei, G., Su, Z., Reynolds, N. P., Arosio, P., Hamley, I. W., Gazit, E. & Mezzenga, R. (2017) Self-Assembling Peptide and Protein Amyloids: From Structure to Tailored Function in Nanotechnology. Chem. Soc. Rev. 46, 4661-4708.

208. Brahmachari, S., Arnon, Z., Frydman-Marom, A., Gazit, E. & Adler-Abramovich, L. (2017) Diphenylalanine as a Reductionist Model for the Mechanistic Characterization of Amyloid Modulators. ACS Nano 11, 5960–5969.

209. Frenkel-Pinter, M., Stempler, S., Tal-Mazaki, S., Losev, Y., Singh-Anand, A., Escobar-Álvarez, D., Lezmy, J., Gazit, E., Ruppin, E. & Segal, D. (2017) Altered Protein Glycosylation Predicts Alzheimer's Disease and Modulates its Pathology in Disease Model Drosophila. Neurobiol. Aging 56, 159-171.

210. Shmueli, M.D., Hizkiahou, N., Peled, S., Gazit, E. & Segal, D. (2017) Total Proteome Turbidity Assay for Tracking Global Protein Aggregation in the Natural Cellular Environment. J. Biol. Methods 4, e69.

211. Frenkel-Pinter, M., Shmueli, M. D., Raz, C., Yanku, M., Gazit, E. & Segal, D. (2017) Interplay between Protein Glycosylation Pathways in Alzheimer’s Disease. Science Adv. 3, e1601576.

212. Chemerovski-Glikman, M., Frenkel-Pinter, M., Mdah, R., Abu-Mokh, A., Gazit, E. & Segal D. (2017) Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by its Pro-Substituted Analogs. Chem. Eur. J. 23, 9618-9624.

213. Schnaider, L., Brahmachari, S., Schmidt, N.W., Mensa, B., Shaham-Niv, S., Bychenko, D., Adler-Abramovich, L., Shimon, L.J.W., Kolusheva, S., DeGrado, W. F. & Gazit, E. (2017) Self-Assembling Dipeptide Antibacterial Nanostructures with Membrane Disrupting Activity. Nature Commun. 8, 1365.

214. Bram, Y., Peled, S., Brahmachari, S., Harlev, M. & Gazit, E. (2017) Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes-Associated Phenotype in a Transgenic Mice Model. Sci. Rep. 7, 14031.

215. Tao, K., Makam, P., Aizen, R. & Gazit, E. (2017) Self-Assembling Peptide Semiconductors. Science 358, eaam9756.

216. Shimanovich, U., Pinotsi, D., Shimanovich, K., Yu, N., Bolisetty, S., Adamcik, J., Mezzenga, R., Charmet, J., Vollrath, F., Gazit, E., Dobson, C.M., Kaminski-Schierle, G., Holland, C., Kaminski, C.F. & Knowles, T.P. J. (2018) Biophotonics with a Native Silk. Macromolecular. Biosci. 18, 1700295.

217. Adler-Abramovich, L., Arnon, Z.A., Sui, X., Azuri, I., Cohen, H.,

Hod, O., Kronik, L., Shimon, L.J.W., Wagner, H.D. & Gazit, E. (2018) Bioinspired Flexible and Tough Layered Peptide Crystals. Adv. Mater. 30, 1704551.

218. Krishna-Kumar, V.G., Paul, A., Gazit, E. & Segal, D. (2018) Mechanistic Insights into Remodeled Tau-derived PHF6 Peptide Fibrils by Naphthoquinone-Tryptophan Hybrids. Sci. Rep. 8, 71.

219. Sade, D., Shaham-Niv, S., Arnon, Z.A., Tavassoly, O. & Gazit, E. (2018) Seeding of Proteins into Amyloid Structures by Metabolite Assemblies May Clarify Certain Unexplained Epidemiological Associations. Open Biol. 8, 170229.

220. Brown, N., Lei, J., Zhan, C., Shimon, L., Adler-Abramovich, L., Wei, G. & Gazit, E. (2018) Structural Polymorphism in a Self-Assembled Tri-Aromatic Peptide System. ACS Nano 12, 3253-3262.

221. Makam, P. & Gazit, E. (2018) Minimalistic Peptide Supramolecular Co-assembly: Expanding the Conformational Space for Nanotechnology. Chem. Soc. Rev. 47, 3406-3420.

222. Gazit, E. (2018) Reductionist Approach in Peptide-Based Nanotechnology. Annu. Rev. Biochem. 87, 533-553.

223. Aizen, R., Tao, K., Rencus-Lazar, S. & Gazit, E. (2018) Functional Metabolite Assemblies - A Review. J. Nanopart. Res. 20, 125.

224. Haj, E., Losev, Y., KrishnaKumar, G., Pichinuk, E., Engel, H., Raveh, A., Gazit, E. & Segal, D. (2018). Integrating In Vitro and In Silico Approaches to Evaluate The "Dual Functionality" of Palmatine Chloride in Inhibiting and Disassembling Tau-Derived VQIVYK Peptide Fibrils. Biochim. Biophys. Acta 1862, 1565-1575.

225. Shaham-Niv, S., Rehak, P., Zaguri, D., Levin, A., Adler-Abramovich, L., Vuković, L., Král, P. & Gazit, E. (2018). Differential Inhibition of Metabolite Amyloid Formation by Generic Fibrillation-Modifying Polyphenols. Commun. Chem. 1, 25.

226. Shaham-Niv, S., Rehak, P., Zaguri, D., Kolusheva, S., Král, P. & Gazit, E. (2018). Metabolite Amyloid-like Fibrils Interact with Model Membranes. Chem. Comm. 54, 4561-4564.

227. Malishev, R., Arad, E., Bhunia, S.K., Shaham-Niv, S., Kolusheva, S., Gazit, E. & Jelinek, R. (2018). Chiral Modulation of Amyloid Beta Fibrillation and Cytotoxicity by Enantiomeric Carbon Dots. Chem. Comm. 54, 7762-7765.

228. Mo, Y., Brahmachari, S., Lei, J., Gilead, S., Tang, Y., Gazit, E. & Wei, G. (2018). The Inhibitory Effect of Hydroxylated Carbon Nanotubes on the Aggregation of Human Islet Amyloid Polypeptide Revealed by a Combined Computational and Experimental Study. ACS Chem. Neurosci. 10, 27578-27583.

229. Levin, A., Michaels, T.C.T., Mason, T.O., Müller, T., Adler-Abramovich, L., Mahadevan, L., Cates, M.E., Gazit, E. & Knowles, T.P.J. (2018). Self-assembly-Mediated Release of Peptide Nanoparticles Through Jets Across Microdroplet Interfaces. ACS Appl. Mater. Interfaces 10, 27578-27583.

230. Amit, M. Yuran, S., Gazit, E., Reches, M. & Ashkenasy, N. (2018). Tailor‐Made Functional Peptide Self‐Assembling Nanostructures. Adv. Mater. 30, 1707083

231. Chemerovski-Glikman, M., Mimouni, M., Dagan, Y., Haj, E., Vainer, I., Allon, R., Blumenthal, E.Z., Adler-Abramovich, L., Segal, D., Gazit, E. & Zayit-Soudry, S. (2018). Rosmarinic Acid Restores Complete Transparency of Sonicated Human Cataract Ex Vivo and Delays Cataract Formation In Vivo. Sci. Rep. 8, 9341.

232. Zaguri, D., Kreiser, T., Shaham-Niv, S. & Gazit, E. (2018). Antibodies towards Tyrosine Amyloid-Like Fibrils Allow Toxicity Modulation and Cellular Imaging of the Assemblies. Molecules 23, 1273.

233. Arnon, Z.A., Pinotsi, D., Schmidt, M., Gilead, S., Guterman, T., Sadhanala, A., Ahmad, S., Levin, A., Walther, P., Kaminski, C.F., Fändrich. M., Kaminski-Schierle, G.S., Adler-Abramovich, L., Shimon, L.J.W. & Gazit, E. (2018). Opal-like Multicolor Appearance of Self-Assembled Photonic Array. ACS Appl. Mater. Interfaces 10, 20783-20789.

234. Baram, M., Gilead, S., Gazit, E. & Miller, Y. (2018). Mechanistic Perspective and Functional Activity of Insulin in Amylin Aggregation. Chem. Sci. 9, 4244-4252.

235. Sher, I., Tzameret, A., Peri-Chen, S., Edelshtain, V., Ioffe, M., Sayer, A., Buzhansky, L., Gazit, E. & Rotenstreich, Y. (2018). Synthetic 9-cis-beta-carotene Inhibits Photoreceptor Degeneration in Cultures of Eye Cups from rpe65rd12 Mouse Model of Retinoid Cycle Defect. Sci. Rep. 8, 6130.

236. Guterman, T. & Gazit, E. (2018). Toward Peptide-based Bioelectronics: Reductionist Design of Conductive Pili Mimetics. Bioelectron. Med. 1, 131-137.

237. Shaham-Niv, S., Arnon, Z.A., Sade, D., Lichtenstein, A., Shirshin, E.A., Kolusheva, S. & Gazit, E. (2018). Intrinsic Fluorescence of Metabolite Amyloids Allows Label-Free Monitoring in Live Cells. Angew. Chem. Int. Ed. Engl. 57, 12444-12447.

238. Bera, S., Mondal, S., Rencus-Lazar, S. & Gazit, E. (2018). Organization of Amino Acids into Layered Supramolecular Secondary Structures. Acc. Chem. Res. 51, 2187-2197.

239. Tavassoly, O., Sade, D., Bera, S., Shaham-Niv, S., Vocadlo, D. & Gazit, E. (2018) Quinolinic Acid Amyloid-Like Fibrillar Assemblies Seed α-Synuclein Aggregation. J. Mol. Biol. 430, 3847-3862.

240. Tao, K., Fan, Z., Sun, L., Makam, P., Tian, Z., Ruegsegger, M., Shaham-Niv, S., Hansford, D., Aizen, R., Pan, Z., Galster, S., Ma, J., Yuan, F., Si, M., Qu, S., Zhang, M., Gazit, E. & Li, J. (2018) Quantum Confined Peptide Assemblies With Tunable Visible To Near-Infrared Spectral Range. Nature Commun. 9, 3217.

241. Frenkel-Pinter, M., Richman, M., Belostozky, A., Abu-Mokh, A., Gazit, E., Rahimipour, S. & Segal, D. (2018) Distinct Effects of O-GlcNAcylation and Phosphorylation of a Tau-Derived Amyloid Peptide on Aggregation of the Native Peptide. Chemistry 24, 14039-14043.

242. Zilberzwige-Tal, S. & Gazit E. (2018) Go with the Flow - Microfluidics Approaches for Amyloids Research. Chem. Asian J. 13, 3437-3447.

243. Chakraborty P. & Gazit E. (2018) Amino Acid Based Self‐Assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks. ChemNanoMat 4, 730-740.

244. Laor, D., Sade, D., Shaham-Niv, S., Zaguri, D., Gartner, M., Basavalingappa, V., Raveh, A., Pichinuk, E., Engel, H., Iwasaki, K., Yamamoto, T., Noothalapati, H. & Gazit, E. (2019) Fibril Formation and Therapeutic Targeting of Amyloid-Like Structures in a Yeast Model of Adenine Accumulation. Nature Commun. 10, 62.

245. Bera S. & Gazit E. (2019) Self-Assembly of Functional Nanostructures by Short Helical Peptide Building Blocks. Protein Pep. Lett. 26, 88-97.

246. Shmueli, M.D., Levy-Kanfo, L., Haj, E., Schoenfeld, A.R., Gazit, E. & Segal, D. (2019) Arginine Refolds, Stabilizes, and Restores Function of Mutant pVHL Proteins in Animal Model of the VHL Cancer Syndrome. Oncogene 38, 1038-1049.

247. Viswanathan, G.K., Mohapatra, S., Paul, A., Arad, E., Jelinek, R., Gazit, E. & Segal, D. (2019) Inhibitory Effect of Naphthoquinone-Tryptophan Hybrid towards Aggregation of PAP f39 Semen Amyloid. Molecules 23, 3279.

248. Arnon, Z.A., Gilead, S. & Gazit E. (2019) Microfluidics for Real-time Direct Monitoring of Self- and Co-Assembly Biomolecular Processes. Nanotechnology 30, 102001.

249. Mondal, S., Jacoby, G., Sawaya, M.R., Arnon, Z.A., Adler-Abramovich, L., Rehak, P., Vuković, L., Shimon, L.J.W., Král, P., Beck, R. & Gazit E. (2019) Transition of Metastable Cross-α Crystals into Cross-β Fibrils by β-Turn Flipping. J. Am. Chem. Soc. 141, 363–369.

250. Chakraborty, P., Guterman, T., Adadi, N., Yadid, M., Brosh, T., Adler-Abramovich, L., Dvir, T. & Gazit, E. (2019) A Self-Healing, All-Organic, Conducting, Composite Peptide Hydrogel as Pressure Sensor and Electrogenic Cell Soft Substrate. ACS Nano 13, 163–175.

251. Guterman, T., Ing, N.L., Fleischer, S., Rehak, P., Basavalingappa, V., Hunashal, Y., Dongre, R., Raghothama, S., Král, P., Dvir, T., Hochbaum, A.I. & Gazit, E. (2019) Electrical Conductivity, Selective Adhesion, and Biocompatibility in Bacteria-Inspired Peptide-Metal Self-Supporting Nanocomposites. Adv. Mater. 31, e1807285.

252. Tao, K., Hu, W., Xue, B., Chovan, D., Brown, N., Shimon, L., Maraba, O., Cao, Y., Zhang, M., Tofail, S., Thompson, D., Li, J., Yang, R. & Gazit, E. (2019) Bioinspired Stable and Photoluminescent Assemblies for Power Generation. Adv. Mater. 31, e1807481.

253. Bera, S., Mondal, S., Tang, Y., Jacoby, G., Arad, E., Guterman, T., Jelinek, R., Beck, R., Wei, G. & Gazit E. (2019) Deciphering the Rules for Amino Acid Co-Assembly Based on Interlayer Distances. ACS Nano 13, 1703-1712.

254. Yu, Y., Gim, S., Kim, D., Arnon, Z.A., Gazit, E., Seeberger, P.H. & Delbianco, M. (2019) Oligosaccharides Self-Assemble and Show Intrinsic Optical Properties. J. Am. Chem. Soc. 141, 4833-4838.

255. Losev, Y., Paul, A., Frenkel-Pinter, M., Abu-Hussein, M., Khalaila, I., Gazit, E. & Segal, D. (2019) Novel Model of Secreted Human Tau Protein Reveals the Impact of the Abnormal N-Glycosylation of Tau on its Aggregation Propensity. Sci. Rep. 9, 2254.

256. Meli, M., Engel, H., Laor, D., Gazit, E. & Colombo, G. (2019) Mechanisms of Metabolite Amyloid Formation: Computational Studies for Drug Design against Metabolic Disorders. ACS Med. Chem. Lett. 10, 666-670.

257. Rencus-Lazar, S., DeRowe, Y., Adsi, H., Gazit, E. & Laor, D. (2019) Yeast Models for the Study of Amyloid-Associated Disorders and Development of Future Therapy. Front. Mol. Biosci. 6, 15.

258. Paul, A., Zhang, B.D., Mohapatra, S., Li, G., Li, Y., Gazit, E. & Segal, D. (2019) Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson’s Disease. Front. Mol. Biosci. 6, 16.

259. Basavalingappa, V., Guterman, T., Tang, Y., Nir, S., Lei, J., Chakraborty, P., Reches, M., Wei, G. & Gazit, E. (2019) Expanding the Functional Scope of Fmoc-Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification. Adv. Sci. 2019, 1900218.

260. Bera, S., Mondal, S., Xue, B., Shimon, L. J. W., Cao, Y. & Gazit, E. (2019) Rigid Helical-Like Assemblies from a Self-Aggregating Tripeptide. Nature Mater. 18, 503-509.

261. Zilberzwige-Tal, S., Levin, A., Toprakcioglu, Z., Knowles, T.P.J., Gazit, E. & Elbaz, J. (2019) Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein. Small 2019, 1901780.

262. Schnaider, L., Ghosh, M., Bychenko, D., Grigoriants, I., Ya'ari, S., Shalev-Antsel, T., Matalon, S., Sarig, R., Brosh, T., Pilo, R., Gazit, E. & Adler-Abramovich, L. (2019) Enhanced Nano-Assembly Incorporated Antimicrobial Composite Materials. ACS Appl. Mater. Interfaces 11, 21334-21342.

263. Arnon, Z. A., Berger, O., Aizen, R., Hannes, K., Brown, N., Shimon, L. J. W. & Gazit, E. (2019) Co-Assembly of Complementary Peptide Nucleic Acid into Crystalline Structures by Microfluidics. Small Methods 3, 1900179.

264. Bera, S., Arad, E., Schnaider, L., Shaham-Niv, S., Castelletto, V., Peretz, Y., Zaguri, D., Jelinek, R., Gazit, E. & Hamley, I. W. (2019) Unravelling the Role of Amino Acid Sequence Order in the Assembly and Function of the Amyloid-β Core. Chem. Comm. 55, 8595-8598.

265. Yuan, C., Ji, W., Xing, R., Li, J., Gazit, E. & Yan, X. (2019) Hierarchically Oriented Organization in Supramolecular Peptide Crystals. Nature Rev. Chem. 3, 567–588.

266. Paul, A., Viswanathan, G. K., Mahapatra, S., Balboni, G., Pacifico, S., Gazit, E. & Segal, D. (2019) Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer’s Disease and Type-2 Diabetes. ACS Chem. Neurosci. 8, 3510-3520.

267. Sun, B., Tao, K., Jia, Y., Yan, X., Zou, Q., Gazit, E. & Li, J. (2019) Photoactive Properties of Supramolecular Assembled Short Peptides. Chem. Soc. Rev. 48, 4387-4400.

268. Tao, K., Xue, B., Li, Q., Hu, W., Shimon, L. J. W., Makam, P., Si, M., Yan, X., Zhang, M., Cao, Y., Yang, R., Li, J. & Gazit, E. (2019) Stable and Optoelectronic Dipeptide Assemblies for Power Harvesting. Mater. Today 30, 10-16.

269. Ji, W., Yuan, C., Chakraboty, P., Gilead, S., Yan, X. & Gazit, E. (2019) Stoichiometry-Controlled Secondary Structure Transition of Amyloid-Derived Supramolecular Dipeptide Co-Assemblies. Commun. Chem. 2, 65.

270. Ji, W., Yuan, C., Zilberzwige-Tal, S., Xing, R., Chakraborty, P., Tao, K., Gilead, S., Yan, X. & Gazit, E. (2019) Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly. ACS Nano 13, 7300-7309.

271. Chakraborty, P., Ghosh, M., Schnaider, L., Adadi, N., Ji, W., Bychenko, D., Dvir, T., Adler-Abramovich, L. & Gazit, E. (2019) Composite of Peptide-Supramolecular Polymer and Covalent Polymer Comprises a New Multi-Functional Bio-Inspired Soft Material. Macromol. Rapid Commun. 40, 1900175.

272. Makam, P., Yamijala, S.S.R.K.C., Tao, K., Shimon, L. J. W., Eisenberg, D. S., Sawaya, M. R., Wong, B. M. & Gazit, E. (2019) Non-proteinaceous Hydrolase Comprised of Phenylalanine Metallosupramolecular Amyloid-Like Structure. Nature Catal. 2, 977–985.

273. Guterman, T., Levin, M., Kolusheva, S., Levy, D., Noor, N., Roichman, Y. & Gazit E. (2019) Real-time In Situ Monitoring of a Tunable Pentapeptide Gel-Crystal Transition. Angew. Chem. Int. Ed. Engl. 58, 16016-16022.

274. Mondal, S., Basavalingapp, V., Jacoby, G., Shimon, L.J.W., Beck, R. & Gazit, E. (2019) Functional Coiled-Coil-like Assembly by Knob-into-Hole Packing of Single Heptad Repeat. ACS Nano 13, 12630-12637.

275. Paul, A., Li, W-H., Viswanathan, G.K., Mohapatra, S., Li, G., Jelinek, R., Gazit, E., Li, Y. & Segal D. (2019) Tryptophan-Glucosamine Conjugates Modulate Tau-Derived PHF6 aggregation at Low concentrations. Chem. Comm. 55, 14621-14624.

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