Prof. Ronit Satchi-Fainaro

פיזיולוגיה ופרמקולוגיה סגל אקדמי בכיר
Prof. Ronit Satchi-Fainaro
Phone: 03-6407427
Another phone: 03-6408733
Fax: 03-6409113
Office: Sackler School of Medicine, 607

Positions

Associate Professor Physiology & Pharmacology, Sackler Faculty of Medicine
President Israeli Chapter of the Controlled Release Society (ICRS)
Chair Tel Aviv University Institutional Animal Care and Use Committee (IAUCUC)
Faculty Coordinator Postgraduate Program in Nanotechnology
Editorial board member Advanced Drug Delivery Reviews
Co-Editor-in-Chief Clinical Cancer Drugs

 

Biography

Education

1999 | Ph.D. University of London, Faculty of Medicine, School of Pharmacy, UK. Thesis title: “PDEPT: Polymer Directed Enzyme Prodrug Therapy”. PI: Ruth Duncan.

 

1996 | Internship in Industrial Pharmacy, Perio Products LTD, Jerusalem, Israel.

 

1995 | B.Pharm. The Hebrew University Jerusalem, Israel.

 

Research

Angiogenic Switch Using Rationally-Designed Theranostic Nanomedicines

Our research interests include investigations related to tumor biology, tumor dormancy, mechanism of action of angiogenesis inhibitors, self-assembly of polymeric architectures and novel approaches to target cancer. Throughout, we have maintained an interest in understanding the biological rationale for the design of polymer therapeutics suitable for transfer into clinical testing. Our primary interests are the molecular basis of tumor angiogenesis and the rational design of polymer therapeutics. Our research includes identification and characterization of genes and microRNAs associated with the switch from a dormant avascular tumor phenotype to a fast-growing angiogenic tumor in human cancers and their corresponding mouse models. We focus on the design and characterization of novel drug delivery platforms, including dendrimers and hyperbranched polymer–based nanoparticles, and the design of highly-selective targeting molecules integrating biology, chemistry, protein engineering, computational approaches, material sciences and nanotechnology to selectively guide drugs into pathological sites. Our vision is that novel approaches to target anticancer, anti-angiogenic drugs, miRNA and siRNAs to endothelial and tumor cells to potentially treat angiogenesis-dependent diseases could transform cancer into a chronically-manageable disease.

 

Research methods used include sequencing, gene cloning, quantitative RT-PCR, immunofluorescence, cell culture, scanning electron microscopy, mass spectrometry, NMR, HPLC, in situ hybridization, bioinformatics, polymer chemistry, molecular imaging, angiogenesis assays, animal models of cancer (human xenografts in mice, syngeneic and transgenic mice models), pharmacokinetics and pharmacodynamics.

 

Publications & Grants

Publications

Weinstain R*, Segal E*, Satchi-Fainaro R and Shabat D, Real-time monitoring of drug release, Chemical Communications (Camb) 46, 553-555 (2010).

 

Ofek P, Fischer W, Calderón M, Haag R and Satchi-Fainaro R, In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers, FASEB Journal, 24, 3122-3134 (2010).

 

Polyak D, Ryppa C, Ofek P, Licha K, Many A, Kratz F and Satchi-Fainaro R, Development of PEGylated doxorubicin-E-[c(RGDfK)2] conjugate for integrin-targeted cancer therapy, Polymers for Advanced Technology, 22, 103–113 (2011).

 

Marom H, Miller K, Bechor-Bar Y, Tsarfaty G, Satchi-Fainaro R* and Gozin M*, Toward development of targeted nonsteroidal antiandrogen-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-gadolinium complex for prostate cancer diagnostics., Journal of Medicinal Chemistry, 53, 6316-6325 (2010). *Corresponding authors.

 

Ofek P, Miller K, Eldar-Boock A, Polyak D, Segal E and Satchi-Fainaro R, Rational design of multifunctional polymer therapeutics for cancer theranostics, Special Theme issue: Polymer Therapeutics as novel nanomedicines, Israel Journal of Chemistry, 50, 185-203 (2010).

 

Eldar-Boock A, Miller K, Sanchis J, Lupu R, Vicent MJ and Satchi-Fainaro R, Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel, Biomaterials, 32, 3862-3874 (2011).

 

Miller K, Eldar-Boock A, Polyak D, Segal E, Benayoun L, Shaked Y and Satchi-Fainaro R, Antiangiogenic Antitumor Activity of HPMA Copolymer-Paclitaxel-Alendronate Conjugate on Breast Cancer Bone Metastasis Mouse Model, Molecular Pharmaceutics, 8,1052-1062 (2011).

 

Clementi C, Miller K, Mero A, Satchi-Fainaro R and Pasut G, Dendritic Poly(ethylene glycol) Bearing Paclitaxel and Alendronate for Targeting Bone Neoplasms, Molecular Pharmaceutics, 8:1063-1072 (2011).

 

Segal E, Pan H, Benayoun L, Kopečková P, Shaked Y, Kopeček J and Satchi-Fainaro R, Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances, Biomaterials, 32:4450-4463 (2011).

 

Scomparin A, Salmaso S, Bersani S, Satchi-Fainaro R, Caliceti P, Novel folated and non-folated pullulan bioconjugates for anticancer drug delivery, European Journal of Pharmaceutical Sciences, 42, 547-558 (2011).

 

Karton-Lifshin N, Segal E, Omer L, Portnoy M, Satchi-Fainaro R*, Shabat D*, A unique paradigm for a turn-on near-infrared cyanine-based probe: non-invasive intravital optical imaging of hydrogen peroxide, Journal of the American Chemical Society (JACS), 133, 10960-10965 (2011). *Corresponding authors.

 

Fante C, Eldar-Boock A, Satchi-Fainaro R, Osborn H, Greco F, Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new anti-angiogenic agent, Journal of Medicinal Chemistry, 54, 5255-5259 (2011).

 

Satchi-Fainaro R*, Ferber S*, Segal E, Ma L, Dixit N, Ijaz A, Hlatky L, Abdollahi A, Almog A, Prospective identification of glioblastoma cells generating dormant tumors, PLoS One, 7: e44395. (2012).

 

Herzog IM, Green KD, Berkov-Zrihen Y, Feldman M, Vidavski RR, Eldar-Boock A, Satchi-Fainaro R, Eldar A, Garneau-Tsodikova S and Fridman M, 6"-Thioether tobramycin analogues: Towards selective targeting of bacterial membranes, Angewandte Chemie, 51, 5652-5656 (2012).

 

Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev R, Munster M, Bril R, Satchi-Fainaro R, Scherer SJ, Shaked Y, Tumor-initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs, Stem Cells -Cancer Stem Cells, 30, 1831-41 (2012).

 

Benayoun L, Schaffer M, Brill R, Gingis-Velitski S, Segal E, Nevelsky A, Satchi-Fainaro R, Shaked Y, Porfimer-sodium (Photofrin-II) in combination with ionizing radiation inhibits tumor initiating cell proliferation and improves glioblastoma treatment efficacy, Cancer Biology & Therapy, 31;14 (2012). (Cover feature).

 

Miller K, Clementi C, Polyak D, Eldar-Boock A, Benayoun L, Barshack I, Shaked Y, Pasut G and Satchi-Fainaro R, Anti-angiogenic activity of polyethyleneglycol-based paclitaxel and alendronate for the treatment of breast cancer bone metastases, Biomaterials, 34: 3795–3806 (2013).

 

Chuderland D, Ben-Ami I, Kaplan-Kraicer R, Grossman H, Komsky A, Satchi-Fainaro R, Eldar-Boock A, Ron-El R, Shalgi R, Hormonal regulation of pigment epithelium derived factor (PEDF) in granulosa cells, Molecular Human Reproduction, 19, 72-81 (2013).

 

Ferber S, Tiram G and Satchi-Fainaro R, Evaluation of microvessels density, morphology and functionality in matrigel plugs by non-invasive intravital microscopy, The Journal of Visualized Experiments (JoVE), in press (2014).

 

Redy O, Kisin-Finfer E, Shiran Ferber, Satchi-Fainaro R*, and Shabat D*, Synthesis and use of qcy7-derived modular probes for detection and imaging of biologically relevant analytes, Nature Protocols, 9:27-36 (2014). *Corresponding authors

 

Kisin-Finfer E, Ferber S, Blau R, Satchi-Fainaro R, Shabat D, Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action, Bioorganic and Medicinal Chemistry Letters, 24:2453-8 (2014).

 

Ferber S, Baabur-Cohen H, Blau R, Epshtein Y and Satchi-Fainaro R, Nanomedicines for personalized theranostics of angiogenesis-dependent diseases, Cancer Letters, in press (2014).

 

Eldar-Boock A, Ryppa C, Sanchis J, Baabur-Cohen H, Many A, Vicent MJ, Kratz F, Satchi-Fainaro R, Integrin-targeted nano-sized polymeric systems for paclitaxel: A comparative study, Polymers for Advanced Technologies, in press (2014).

 

Markovsky E, Baabur-Cohen H, Satchi-Fainaro R, Anticancer polymeric nanomedicine bearing synergistic drug combination is superior to a mixture of individually-conjugated drugs, Journal of Controlled Release, in press (2014).

 

 

Reviews

Ofek P, Miller K, Eldar-Boock A, Polyak D, Segal E and Satchi-Fainaro R, Rational design of multifunctional polymer therapeutics for cancer theranostics, Special Theme issue: Polymer Therapeutics as novel nanomedicines, Israel Journal of Chemistry, 50, 185-203 (2010).

 

David A and Satchi-Fainaro R, Special Theme issue: Polymer Therapeutics as novel nanomedicines, Editorial- Polymer Therapeutics- from bench to bedside, Israel Journal of Chemistry, 50, 145-146 (2010).

 

Markovsky E, Baabur-Cohen H, Eldar-Boock A, Omer L, Tiram G, Ferber S, Ofek P, Polyak D, Scomparin A and Satchi-Fainaro R, Administration, distribution, metabolism and elimination of polymer therapeutics, Theme issue: Drug Delivery Research in Europe, Journal of Controlled Release, 161, 446–460 (2012).

 

Eldar-Boock A*, Polyak D*, Scomparin A, Satchi-Fainaro R, Nano-sized polymers and liposomes designed to deliver combination therapy for cancer, Current Opinion in Biotechnology, 24: 682–689 (2013).

 

Ofek P, Tiram G, Satchi-Fainaro R, RNAi Anti-angiogenic Nanomedicines, Advanced Drug Delivery Reviews, in press (2014).

 

Polyak D*, Eldar-Boock A*, Baabur-Cohen H and Satchi-Fainaro R, Polymer conjugates for focal and targeted delivery of drugs, Polymers for Advanced Technologies, 24, 777–790 (2013).

 

Tiram G, Scomparin A, Ofek P and Satchi-Fainaro R, Interfering cancer with polymeric siRNA nanocarriers, Journal of Biomedical Nanotechnology, 10, 50-66 (2014).

 

Ben-Shushan D*, Markovsky E*, Gibori H*, Tiram G, Scomparin A, Satchi-Fainaro R, Overcoming obstacles in microRNA delivery towards improved cancer therapy, Drug Delivery and Translational Research, 4, 38-49 (2014).

 

 

Chapters

Eldar-Boock A, Polyak D and Satchi-Fainaro R, Ligand-assisted vascular targeting of polymer therapeutics, In Drug Delivery in Oncology - From Basic Research to Cancer Therapy, Eds. Kratz F and Senter P, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2, p. 591-625 (2011).

 

Baabur-Cohen H, Omer L, and Satchi-Fainaro R, Recent progress in polymer therapeutics as nanomedicines, In Handbook of Harnessing biomaterials in Nanomedicine: Preparation, toxicity and applications, Ed. Peer D, Pan Stanford Publishing Pte. Ltd., Hackensack, NJ, USA, Chapter 4, p. 77-122 (2011).

 

Gabizon A, Shmeeda H, Baabur H and Satchi-Fainaro R, Targeting the folate receptor with liposomes and polymer therapeutics, In Targeted Drug Strategies for Cancer and Inflammation, Eds. Leamon C and Jackman A, Springer-Verlag, Heidelberg, Germany, p. 217-247 (2011).

 

 

Grants

  • 2012-2016       MAGNET Rimonim Consortium, Office of the Chief Scientist of the Ministry of Industry, Trade & Labor: "siRNA delivery to ovarian cancer”.                                               
  • 2012-2017       Israel National Nanotechnology Initiative (INNI), Focal Technology Area in nanotechnology, "Theranostic Nanomedicines for Personalized Medicine”
  • 2014-2019       European Research Council (ERC) Consolidator Award. PolyDorm: "Uncovering the molecular and cellular mechanism of tumor dormancy for the rational design of theranostic nanomedicines".

 

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