Dr. Or Friedman

Dr. Friedman Graduated from the Rapaport school of medicine, Technion Institute of Technology and the plastic and aesthetic surgery residency program of the Tel Aviv Medical Center. 

Dr. Friedman was awarded the first Kahn foundation grant for outstanding research physicians. Supported by the fund Dr. Friedman developed the basic plastic surgery lab, now at the forefront the field's research in the world. 

Dr. Friedman is a member of the American Society of Plastic Surgeons, The American Society of Reconstructive Microsurgery, and International Confederation of Plastic Surgery Societies.  He serves on various professional committees and as an associate editor of the PRS global open journal. 

Happy to be of service,

 www.f-md.com

Twitter - @Friedman_MD

Instagram - @Friedman_MD

Facebook - @prsor

Education and Training

2020 - 2021   Tel-Aviv University

                       MBA

2014 - 2019   Tel-Aviv Medical Center                                

                       Plastic Reconstructive Surgery                                                                          

2006 - 2014   Technion - Israel Institute of Technology                                                                     

                       MD

Positions

2019                  American Society of Plastic Surgeons - Member of the Anual meeting educational program committee

2019                  American Society of Plastic Surgeons - Member of the Researcher education subcommittee 

2018                  American Society of Plastic Surgeons - Member of the Plastic surgery education network subcommittee

2017 - present   PRS global open – Editorial board member

2017 - present   PRS – Resident advisory board 

2016                  American Society of Plastic Surgeons – Member of the PSEN sub-committee

2016 - present   Kahn foundation - Research fellow, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel

Selected Honors

2018                ISPRES/ICOPLAST Young Plastic Surgeon Award. Plastic surgery the meeting, Chicago, USA

2018                Best Breast paper award of the PRS. Plastic surgery the meeting, Chicago, USA

2017                Young investigator scientific award of The Transplant Society. 13th congress of the international society of vascularized composite allotransplantation, Salzburg, Austria

2017                Best paper award of the PRS global open. Plastic surgery the meeting, Orlando, USA

2016                Outstanding research physician scholarship of the “Kahn” foundation, Tel-Aviv, Israel

2014                Best basic science MD research thesis. Rapaport school of medicine, Technion - Israel Institute of technology, Haifa, Israel

Professional Memberships 

2017                The Transplantation Society – Member

2017                American Society of Reconstructive Microsurgery – Candidate membership

2016                American Society of Plastic Surgeons – Member

2014                Israel Medical Association - member

Ski, Snowboard, Sailing, Surfing, Horology

A. Personal Statement

My clinical interests include plastic reconstructive surgery and reconstructive microsurgical techniques for limb salvage. My research interests focus on Vascularized Composite Allotransplantation (VCA) immunology and cryopreservation.

B. Contributions to Science

1. My research has primarily focused on VCA immunology and cryopreservation. My contribution to the selected peer-reviewed publications includes the study design, microsurgical operations, and manuscript preparation.

1. Friedman O, Carmel N, Sela M, Abu Jabal A, Inbal A, Ben Hamou M, Krelin Y, Gur E and Shani N. 2017. Immunological and inflammatory mapping of vascularized composite allograft rejection processes in a rat model. PLoS One. 10.1371/journal.pone.0181507.
2. Arav A, Friedman O, Natan Y, Gur E, Shani N. 2017 Rat hindlimb cryopreservation and transplantation - A step towards “organ banking”. Am J Transplant. . doi: 10.1111/ajt.14320. *equal contribution
3. Friedman O, Orvieto R, Fisch B, Felz C, Freud E, Ben-Haroush A, Abir R. 2011 Possible improvements in human ovarian grafting by various host and graft treatments. Hum Reprod 2012 Feb;27(2):474-82. Epub 2011 Nov 23
4. D.Inbal A, Sela M, Kalchenko V, Kuznetsov Y, Friedman O, Zaretski A, Tirza G, Zipori D, Gur E, and Nir Shani. 2015 Targeted Delivery of Adipose-Derived Stem Cells into a Transplant by Direct Intra-Arterial Administration. Journal of Stem Cell Research & Therapy

2. Over the last six years, my research has mainly concentrated on Rat microsurgical models that simulate composite soft tissue and complete hindlimb transplantation which I have adapted and performed clinically. I have been intimately involved in the study design, animal work, immunological studies, teaching and manuscript preparation.

1. Oron G, Ao A, Friedman O, Fisch B, Zhang XY, Ben-Haroush A, Peled Y, Abir R. 2011 Expression of Neurotrophin 3 and its tropomyosin-related kinase receptor C in human preantral follicles. Fertil Steril. 2011 May;95(6):2056-2062. Epub 2011 Mar 10
2. Sela M, Tirza G, Ravid O, Volovitz I, Solodeev I, Friedman O, Zipori D, Gur E,Krelin Y, Shani N. 2015 NOX1-induced accumulation of reactive oxygen species in abdominal fat-derived mesenchymal stromal cells impinge on long-term proliferation. Cell Death Dis. 2015 Apr 16

3. I helped establish the microsurgical laboratory for research and teaching in TASMC

C. Research Support

Name: Cryopreservation of organs and tissue for Transplantation after patient stabilization

Period: 06/2017-06/2018

Role: Key Personnel

Funding source: Israeli Department of  Defense

Name Rat hindlimb VCA model cryopreservation,

Period: 09/2016 – 12/2019

Role: PI

Funding source: ”Kahn" foundation scholarship for outstanding research physician

1. Friedman O, Orvieto R, Fisch B, et al., Possible improvements in human ovarian grafting by various host and graft treatments. Hum Reprod 2012 Feb;27(2):474-82. 
2. Oron G, Ao A, Friedman O, et al., Expression of Neurotrophin 3 and its tropomyosin-related kinase receptor C in human preantral follicles. Fertil Steril. 2011 May;95(6):2056-2062.
3. Sela M, Tirza G, Ravid O, Volovitz I, Solodeev I, Friedman O, et al., NOX1-induced accumulation of reactive oxygen species in abdominal fat-derived mesenchymal stromal cells impinges on long-term proliferation. Cell Death Dis. 2015 Apr 16
4. Inbal A, Sela M, Kalchenko V, Kuznetsov Y, Friedman O, et al.,Targeted Delivery of Adipose-Derived Stem Cells into a Transplant by Direct Intra-Arterial Administration. Journal of Stem Cell Research & Therapy. November 30, 2016
5. Friedman O, Zaretzki A. Silicone breast implant and automatic implantable cardioverter defibrillator (AICD), can they co-exist? A case report. Plast Reconstr Surg Glob Open. 2016 
6. Friedman O, Arad E, Ben Amotz O. Bodybuilder nightmare: black market steroid injection gone wrong. A case report. Plast Reconstr Surg Glob Open. 2016 Sep 29;4(9):e1040. 
7. Friedman O, Carmel N, Sela M, et at., Immunological and inflammatory mapping of vascularized composite allograft rejection processes in a rat model. PLoS One. 2017 Jul 26;12(7):e0181507. 
8. Barnea Y, Friedman O, Arad E, Barsuk D, Menes T, Zaretski A, Leshem D, Gur E, Inbal A. An Oncoplastic Breast Augmentation Technique for Immediate Partial Breast Reconstruction following Breast Conservation. Plast Reconstr Surg. 2017 Feb;139(2):348e-357e. doi: 10.1097/PRS.0000000000003005. PubMed PMID: 28121854.
9. Arav A, Friedman O, Natan Y, Gur E, Shani N. Rat hindlimb cryopreservation and transplantation - A step towards “organ banking”. Am J Transplant. 2017 Apr 19. 
10. Friedman O, Barnea Y, Hafner A. Underdiagnosed and disfiguring - Radiation-induced morphea following breast cancer treatment. Breast. 2018 Jun;39:97-100.
11. Shechter S, Arad E, Inbal A, Friedman O, Gur E, Barnea Y. DIEP Flap Breast Reconstruction Complication Rate in Previously Irradiated Internal Mammary Nodes. J Reconstr Microsurg. 2018 Apr 19.
12. Friedman O, Koren A, Niv R, Mehrabi JN, Artzi O. The toxic edge-A novel treatment for refractory erythema and flushing of rosacea. Lasers Surg Med. 2018 Oct 12. doi: 10.1002/lsm.23023. [Epub ahead of print] PubMed PMID: 30311683.
13. Safra T, Shehadeh W, Koren A, Salameh F,  Friedman O, Sprecher E, Artzi O. Early intervention with pulse dye and CO2 ablative fractional lasers to improve cutaneous scarring post-lumpectomy: a randomized controlled trial on the impact of intervention on final cosmesis. Lasers Med Sci (2019). https://doi.org/10.1007/s10103-019-02788-3
14. Shani N, Friedman O, Arav A, Natan Y, Gur E. Cryopreservation and Transplantation of Vascularized Composite Transplants: Unique Challenges and Opportunities. Plast Reconstr Surg (2019)
15. Shechter S, Friedman O, Inbal A, Arad E, Menes T, Barsuk D, Gur E, Barnea Y. Oncoplastic partial breast reconstruction improves patient satisfaction and aesthetic outcome for central breast tumours. ANZ J Surg. 2019 May;89(5):536-540. doi: 10.1111/ans.15078. Epub 2019 Mar 20. PubMed PMID: 30895710. 
16. Artzi O, Koren A, Niv R, Mehrabi J, Friedman O. The Scar Bane, Without the Pain: A New Approach in the Treatment of Elevated Scars: Thermomechanical Delivery of Topical Triamcinolone Acetonide and 5-Fluorouracil. Dermatol Ther (Heidelb) (2019). https://doi.org/10.1007/s13555-019-0298-x
17. Friedman O, Fliss E, Inbal A, Arad E, Frand J, Barnea Y. Latissimus Dorsi Flap: A Winning Hand for Breast Reconstruction Salvage. Isr Med Assoc J. 2019 Apr;21(4):260-264. PubMed PMID: 31032568.
18.  Artzi O, Cohen S, Koren A, Niv R, Friedman O. Dual-plane hyaluronic acid treatment for atrophic acne scars. J Cosmet Dermatol. 2019;00:1–6. h t t p s : //doi.org/10.1111/jocd.12991
19. Horowitz G, Warshavsky A, Friedman O, et al. Balsa wood for precise intra-operative bone contouring in fibula free-flap mandible reconstruction. Eur Arch Otorhinolaryngol (2019). https://doi.org/10.1007/s00405-019-05496-4​
20. Borenstein A, Friedman O. Multilevel Breast Reduction: A Retrospective Study of 338 Breast Reduction Surgeries. Plast Reconstr Surg Glob Open. 2019 Aug 30;7(8):e2427. doi: 10.1097/GOX.0000000000002427. eCollection 2019 Aug.
21. Artzi O, Koren A, Niv R, Mehrabi JN, Mashiah J, Friedman O. A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery. J Cosmet Dermatol. 2019 Oct 19.
22. Koren A, Isman G, Friedman O, Salameh F, Niv R, Shehadeh W, Artzi O. Evaluation of subject response following treatment for pigmentation or wrinkles using a diode laser. J Cosmet Dermatol. 2019 Oct 28. doi: 10.1111/jocd.13200.
23. Artzi O, Mehrabi JN, Heyman L, Friedman O, Mashiah J. Treatment of port wine stain with Tixel-induced rapamycin delivery following pulsed dye laser application. Dermatol Ther. 2019 Nov 20:e13172. doi: 10.1111/dth.13172.
24. Borenstein A, Azaria R, Inbar R, Friedman O. The Paper Mache Bra: A Postsurgical Breast Taping Technique. Plast Reconstr Surg Glob Open. 2019 Sep 30;7(9):e2407. doi: 10.1097/GOX.0000000000002407. eCollection 2019 Sep. PubMed PMID: 31942386; PubMed Central PMCID: PMC6908377.
25. Friedman O, Gofstein D, Arad E, Gur E, Sprecher E, Artzi O. Laser pretreatment for the attenuation of planned surgical scars: A randomized self-controlled hemi-scar pilot study. J Plast Reconstr Aesthet Surg. 2019 Dec 16. pii: S1748-6815(19)30556-X. doi: 10.1016/j.bjps.2019.11.046. [Epub ahead of print] PubMed PMID: 31926893.
26. Borenstein A, Friedman O. Combined Breast Implant Explantation and Multilevel Mastopexy Technique. Plast Reconstr Surg Glob Open. 2019 Sep 30;7(9):e2429. doi: 10.1097/GOX.0000000000002429. eCollection 2019 Sep. PubMed PMID: 31741816; PubMed Central PMCID: PMC6799404.

Book chapters

1. Friedman O, Orvieto R, Fisch B, Abir R. The importance of melatonin in ovaries of higher mammals. New Developments in Melatonin Research. (2013) 139-159. 

Abstracts and/or Proceedings

1. Human preantral follicles from fetuses, girls, and women express Neurotrophin 3 and its receptor tropomyosin-related kinase c. AYALA 2011, Tel-Aviv, Israel
2. Melatonin, hyaluronan, vascular endothelial growth factor and vitamin e improve human ovarian grafting. AYALA 2011, Tel-Aviv, Israel
3. Neurotrophin 3 and its receptor tropomyosin-related kinase receptor C in human preantral follicles from fetuses, girls and women. ESHRE 2011, Stockholm, Sweden
4. Host and graft treatments with melatonin, hyaluronan, vascular endothelial growth factor-A, and vitamin E can improve human ovarian tissue grafting for fertility restoration. ESHRE 2011, Stockholm, Sweden
5. A composite tissue allotransplantation (CTA) rat model using vascularized groin flap. the annual meeting of the Israel society for plastic and aesthetic surgery 2012, Tel-Aviv, Israel
6. Comparison of the immunological networks that control vascularized composite allograft (VCA) rejection and vascularized composite autograft acceptance: can it teach us how to prevent allograft rejection? the annual meeting of the Israel society for plastic and aesthetic surgery 2013, Tel-Aviv, Israel 
7. Local intravascular delivery of mesenchymal stem cells (MSCS) in vascularized composite allotransplantation (VCA) - a novel immunosuppression model in rats. the annual meeting of the Israel society for plastic and aesthetic surgery 2014, Tel-Aviv, Israel
8. Ulna and Radius reconstruction with free fibula flap. the annual meeting of the Israel society for plastic and aesthetic surgery 2015, Tel-Aviv, Israel
9. Innovations in mandibular and maxillary reconstruction. The annual meeting of the American society for reconstructive microsurgery 2016, Hawaii, USA
10. Simplifying the Planning Process of Mandible Reconstruction with Free Fibula Flap. congress of world society for reconstructive microsurgery 2017, Seul, South Korea
11. Vascularized Composite Allograft Rejection Is Markedly Influenced by Early-Stage Damage-Related Inflammatory Responses. congress of world society for reconstructive microsurgery 2017, Seul, South Korea
12. Ulna and Radius reconstruction with free fibula flap. Duke university Flap course 2017, Durham, USA
13. Rat hindlimb cryopreservation and transplantation - A step towards “organ banking”. Plastic surgery the meeting 2017, Orlando, USA
14. Vascularized Composite Allograft Rejection Is Markedly Influenced by Early-Stage Damage-Related Inflammatory Responses. Plastic Surgery The meeting 2017, Orlando, USA
15. Rat hindlimb cryopreservation and transplantation - A step towards “organ banking”. International Society of Vascularized Composite Allotransplantation 2017, Salzburg, Austria
16. Vascularized Composite Allograft Rejection Is Markedly Influenced by Early-Stage Damage-Related Inflammatory Responses. 421 annual meeting of the Israel society for plastic and aesthetic surgery 2017, Tel-Aviv, Israel
17. Rat hindlimb cryopreservation and transplantation - A step towards “organ banking”. 42 annual meeting of the Israel society for plastic and aesthetic surgery 2017, Tel-Aviv, Israel

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