Prof. Rafi Korenstein

פיזיולוגיה ופרמקולוגיה אמריטוס
Prof. Rafi Korenstein
Phone: 03-6406042
Fax: 03-6408982
Office: Sackler School of Medicine, 614

Positions

Professor, Department of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University

Chair, Commission K of the Israel National Committee for Radio Science of Israel Academy of Sciences and Humanities on Electromagnetics in Biology and Medicine

Editorial Board, Bioelectromagnetics

 

Research

Interaction of Nanomaterials and Electromagnetic Fields with Cells

Research activity addresses the following lines of research:

  • Adsorption and uptake of nanoparticles by cells in relation to drug delivery and toxicity
  • Enhancement of uptake by electrical and chemical means
  • Treatment of cancer by electrochemical based approach
  • Assessment of genetic and epigenetic risks following in-vitro exposure to electromagnetic fields associated with cell phone communication
  • Physiological regulation and underlying mechanism of cell membrane-cortical skeleton nanoscale mechanical fluctuations.

 

Research methods used include routine cell biology and biochemical methodologies with emphasis on special cutting edge light microscopies possessing nanometric resolution such as Digital Holographic Microscopy.

 

Publications & Grants

Publications

Keisari, Y., Hochman, I., Confino, H., Korenstein, R., Kelson, I. (2014) Activation of local and systemic anti-tumor immune responses by ablation of solid tumors with intratumoral electrochemical or alpha radiation treatments. Cancer Immunol Immunother 63,1-9

 

Madi L., Rosenberg-Haggen, B., Nyska, A., and Korenstein, R. (2013) Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants. Exp Dermatol 22, 74-77.

 

Hole P., Sillence K., Hannell C., Maguire CM Roesslein M, Suarez G, Capracotta S, Magdolenova Z, Horev-Azaria L, Dybowska A, Cooke L, Haase A, Contal S, Manø S, Vennemann A, Sauvain J-J, Staunton KC, Anguissola S, Luch A, Dusinska M, Korenstein R, Gutleb AC, Wiemann M, Prina-Mello A, Riediker M, Wick P., (2013) Interlaboratory comparison of size measurements on nanopartcles using Nanoparticle Tracking Analysis (NTA). J Nanopart Res 15, 2101.

 

Wolf-Goldberg T., Barbul, A., Ben-Dov N., Korenstein R. (2013) Low electric fields induce ligand-independent activation of EGF receptor and ERK via electrochemical elevation of H+ and ROS concentrations. Biochim Biophys Acta 1833, 1396–1408

 

Ben-Dov N. and Korenstein R. (2013) Proton-induced endocytosis is dependent on cell membrane fluidity, lipid-phase order and the membrane resting potential. Biochim Biophys Acta 1828, 2672-2681

 

Ben-Dov N., and Korenstein R. (2013) Actin-cytoskeleton rearrangement modulates proton-induced uptake. Exp Cell Res. 319, 946-954.

 

Horev-Azaria L., Baldi G., Beno D., Bonacchi D, Golla-Schindler U, Kirkpatrick JC, Kolle S, Landsiedel R, Maimon O, Marche PN, Ponti J, Romano R, Rossi F, Sommer D, Uboldi C, Unger RE, Villiers C, Korenstein R. (2013) Predictive Toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data. Part Fibre Toxicol 10:32.

 

Goñi-de-Cerio F., Mariani V., Cohen D., Korenstein R. et al., (2013) Biocompatibility study of two di-block co-polymeric NPs for biomedical applications by in vitro toxicity testing. J Nanopart Res 15:2036

 

Ben-Dov N, Rozman Grinberg I, Korenstein R (2012) Electroendocytosis Is Driven by the Binding of Electrochemically Produced Protons to the Cell’s Surface. PLoS One 7: e50299

 

Shock, I., Barbul, A., Girshovitz, P. Nevo, U., Korenstein, R., Shaked N.T. (2012) Optical phase nanoscopy in red blood cells using low-coherence spectroscopy. J Biomed Optics 17, 101509

 

Ben-Dov N. and Korenstein R. (2012) Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface. PLoS One 7, E35204

 

Ben-Dov N. and Korenstein R. (2012) Cell-based detection of electrochemical oxidative stress by a fluorescent tryptophan intermediate. Bioelectrochem 84:11-17

 

Cohen S, Coué G, Beno D, Korenstein R, and Engbersen J. F.J. (2011) Bioreducible poly(amidoamine)s as carriers for intracellular protein delivery to intestinal cells. Biomaterials 33:614-23

 

Horev-Azaria L, Kirkpatrick CJ, Korenstein R et al., (2011) Predictive toxicology of cobalt nanoparticles and ions: comparative in-vitro study of different cellular models using methods of knowledge discovery from data. Toxicol Sci 122:489-501

 

 

Chapter in Book

Keisari Y. and Korenstein R. (2013) In-situ ablation of solid tumors by electric forces and its effect on the tumor microenvironment and anti-tumor immunity. In: Tumor Ablation: effects on systemic and local anti-tumor immunity and on other tumor-microenvironment interactions. Y. Keisari, Ed. Springer, Dordrecht, 2013, Ch. 8, pp. 133-153.

 

 

Grants

2011-2015 European Commission - EP7 EC consortium on "Research Infrastructures for processing, analysis and characterization of engineered nanomaterials" (acronym – "QNano", 27 partners)

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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