Prof. Shai Efrati

רפואה פנימית סגל אקדמי קליני
Prof. Shai Efrati
External phone: 08-9779395
Fax: 08-9779748


Shai Efrati, MD, is an associate professor at the Sackler School of Medicine and the Sagol School of Neuroscience at Tel Aviv University. He also serves as director of the Sagol Center for Hyperbaric Medicine and Research and the Head of the Nephrology Unite at Shamir Medical Center (formerly Assaf-Harofeh Medical Center) in Israel. Under his leadership, The Sagol Center has become one of the largest hyperbaric medicine centers in the world, currently treating more than 200 patients daily. Efrati received his M.D. from Ben Gurion University in 2000, and completed his residency at Shamir Medical Center, specializing in Internal Medicine and Nephrology. Since 2005, Efrati has served as the Head of Research and Development unit at Shamir Medical Center, and since 2014, he is the director of the Nephrology department


Efrati also completed training in diving and hyperbaric medicine at the Israel Naval Institute in Haifa. At 2008, Prof. Efrati became the Director of Sagol Center for Hyperbaric Medicine and Research. In addition, since 2008, Efrati has served as chairman of the Israeli Society for Diving and Hyperbaric Medicine.


Efrati is co-founder and Chair of the Medical Advisory Board to Aviv Scientific, which leverages Efrati’s research on HBOT to improve brain and physical performance in healthy aging adults.

Research Interests

Professor Efrati’s research focuses on the effects of HBOT on physiology and various brain pathologies. He has conducted both preclinical and clinical studies for stroke, traumatic brain injury, post-concussion syndrome, fibromyalgia syndrome, and most recently, the aging associated functional decline. On-going research projects include the effects of HBOT on sever emotional trauma and PTSD.

The preclinical studies focus on the mechanisms of HBOT including normalization of mitochondrial function, stem cells migration and differentiation, angiogenesis, neurogenesis, anti-inflammatory effects, recovery of renal function after acute kidney injuries and hypertension.  


Cognitive Performance and Aging

Hadanny, A., M. Rittblat, M. Bitterman, I. May-Raz, G. Suzin, R. Boussi-Gross, Y. Zemel, M. Catalogna, and S. Efrati.
Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients–a retrospective analysis.  
Restorative Neurology and Neuroscience Preprint (2020): 1-15.

Shapira, R., S. Efrati, and U. Ashery.
Hyperbaric Oxygen Therapy as a New Treatment Approach for Alzheimer's Disease.  
Neural Regen Res 13, no. 5 (May 2018): 817-18.


Shapira, R., B. Solomon, S. Efrati, D. Frenkel, and U. Ashery.
Hyperbaric Oxygen Therapy Ameliorates Pathophysiology of 3xtg-Ad Mouse Model by Attenuating Neuroinflammation.
Neurobiol Aging 62 (Feb 2018): 105-19.


Vadas, D., L. Kalichman, A. Hadanny, and S. Efrati.
Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance.
Front Integr Neurosci 11 (2017): 25.



Traumatic Brain Injury & Post Concussion

Boussi-Gross, R., H. Golan, G. Fishlev, Y. Bechor, O. Volkov, J. Bergan, M. Friedman, D. Hoofien, N. Shlamkovitch, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial.
PLoS One 8, no. 11 (2013): e79995.


Efrati, S. and E. Ben-Jacob.
Reflections on the Neurotherapeutic Effects of Hyperbaric Oxygen.
Expert Rev Neurother 14, no. 3 (Mar 2014): 233-6.


Hadanny, A., S. Abbott, G. Suzin, Y. Bechor, and S. Efrati.
Effect of Hyperbaric Oxygen Therapy on Chronic Neurocognitive Deficits of Post-Traumatic Brain Injury Patients: Retrospective Analysis.
BMJ Open 8, no. 9 (Sep 28 2018): e023387.

Hadanny, A. and S. Efrati.
Treatment of Persistent Post-Concussion Syndrome Due to Mild Traumatic Brain Injury: Current Status and Future Directions.
Expert Rev Neurother 16, no. 8 (Aug 2016): 875-87.


Hadanny, A., H. Golan, G. Fishlev, Y. Bechor, O. Volkov, G. Suzin, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen Can Induce Neuroplasticity and Improve Cognitive Functions of Patients Suffering from Anoxic Brain Damage.
Restor Neurol Neurosci 33, no. 4 (2015): 471-86.


Tal, S., A. Hadanny, N. Berkovitz, E. Sasson, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen May Induce Angiogenesis in Patients Suffering from Prolonged Post-Concussion Syndrome Due to Traumatic Brain Injury.
Restor Neurol Neurosci 33, no. 6 (2015): 943-51.


Tal, S., A. Hadanny, E. Sasson, G. Suzin, and S. Efrati.
Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients.
Front Hum Neurosci 11 (2017): 508.



Post Stroke Patients

Boussi-Gross, R., H. Golan, O. Volkov, Y. Bechor, D. Hoofien, M. S. Beeri, E. Ben-Jacob, and S. Efrati.
Improvement of Memory Impairments in Poststroke Patients by Hyperbaric Oxygen Therapy.
Neuropsychology 29, no. 4 (Jul 2015): 610-21.


Efrati, S., G. Fishlev, Y. Bechor, O. Volkov, J. Bergan, K. Kliakhandler, I. Kamiager, N. Gal, M. Friedman, E. Ben-Jacob, and H. Golan.
Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients--Randomized, Prospective Trial.
PLoS One 8, no. 1 (2013): e53716.



Chronic Pain Syndrome- Fibromyalgia

Ablin, J. N., S. Efrati, and D. Buskila.
Building up the Pressure on Chronic Pain.
Clin Exp Rheumatol 34, no. 2 Suppl 96 (Mar-Apr 2016): S3-5.


Efrati, S., H. Golan, Y. Bechor, Y. Faran, S. Daphna-Tekoah, G. Sekler, G. Fishlev, J. N. Ablin, J. Bergan, O. Volkov, M. Friedman, E. Ben-Jacob, and D. Buskila.
Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome--Prospective Clinical Trial.
PLoS One 10, no. 5 (2015): e0127012.


Efrati, S., A. Hadanny, S. Daphna-Tekoah, Y. Bechor, K. Tiberg, N. Pik, G. Suzin, and R. Lev-Wiesel.
Recovery of Repressed Memories in Fibromyalgia Patients Treated with Hyperbaric Oxygen - Case Series Presentation and Suggested Bio-Psycho-Social Mechanism.
Front Psychol 9 (2018): 848.

Hadanny, A., Y. Bechor, M. Catalogna, S. Daphna-Tekoah, T. Sigal, M. Cohenpour, R. Lev-Wiesel, and S. Efrati.
Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering from Fibromyalgia with a History of Childhood Sexual Abuse-Randomized Controlled Trial.
Front Psychol 9 (2018): 2495.

Lev-Wiesel, R., Y. Bechor, S. Daphna-Tekoah, A. Hadanny, and S. Efrati.
Brain and Mind Integration: Childhood Sexual Abuse Survivors Experiencing Hyperbaric Oxygen Treatment and Psychotherapy Concurrently.
Front Psychol 9 (2018): 2535.


Myocardial Dysfunction

Leitman, M., S. Efrati, S. Fuchs, A. Hadanny, Z. and Vered.
The effect of hyperbaric oxygenation therapy on myocardial function. 
The International Journal of Cardiovascular Imaging (Jan 2020).



Erectile Dysfunction

Hadanny, A., E. Lang, L. Copel, O. Meir, Y. Bechor, G. Fishlev, J. Bergan, M. Friedman, A. Zisman, and S. Efrati.
Hyperbaric Oxygen Can Induce Angiogenesis and Recover Erectile Function.
Int J Impot Res 30, no. 6 (Nov 2018): 292-99.



Safety of Hyperbaric Oxygen Treatment

Hadanny A, Zubari T, Tamir-Adler L, Bechor Y, Fishlev G, Lang E, Polak N, Bergan J, Friedman M, Efrati S
Hyperbaric oxygen therapy effects on pulmonary functions: a prospective cohort study
BMC Pulmonary Medicine volume 19, Article number: 148 (2019)


Hadanny, A., O. Meir, Y. Bechor, G. Fishlev, J. Bergan, and S. Efrati.
The Safety of Hyperbaric Oxygen Treatment--Retrospective Analysis in 2,334 Patients.
Undersea Hyperb Med 43, no. 2 (Mar-Apr 2016): 113-22.


Hadanny, A., O. Meir, Y. Bechor, G. Fishlev, J. Bergan, and S. Efrati.
Seizures During Hyperbaric Oxygen Therapy: Retrospective Analysis of 62,614 Treatment Sessions.
Undersea Hyperb Med 43, no. 1 (Jan-Feb 2016): 21-8.

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