Prof. Yuval Ebenstein

Prof. Yuval Ebenstein is a scientist and entrepreneur with years of experience in translational research. Yuval is head of the NanoBioPhotonix Lab and the founder of the Tel Aviv university Entrepreneurship Center. In his lab, Yuval combines Chemistry, Physics, Biology and bioinformatics in order to study the human genome. His lab explores genomes utilizing tools and reagents from the realm of nano-technology, zooming in on single cells, single chromosomes and single molecules. Yuval is the winner of two ERC awards for developing genomic technologies and is the founder of JaxBio, a liquid biopsy methylation-based diagnostics startup.

Education:
                                                                                                                              

      2000: B.Sc. The Hebrew University, Physical Chemistry, Jerusalem, Israel

      2001: M.Sc. The Hebrew University, Physical Chemistry, Jerusalem, Israel

      2007: Ph.D. The Hebrew University, Physical Chemistry, Jerusalem, Israel

Academic and Professional Experience:
                                                                                                                                          

2006-2011:       DOE Institute for Genomics and Proteomics, Department of Chemistry and Biochemistry, UCLA, Los Angeles, USA

Postdoctoral Research Fellow under the supervision of Prof. Shimon Weiss.

2011- 2016:     Tel-Aviv University, Department of Physical Chemistry, School of Chemistry, Tel-Aviv, Israel

Senior lecturer and PI

2016- 2021       Tel-Aviv University, Department of Physical Chemistry, School of Chemistry, Tel-Aviv, Israel

Associate professor

2018- 2021       Tel-Aviv University, Entrepreneurship and Innovation Center,

Founder and Academic director

2021- To date  Tel-Aviv University, Department of Physical Chemistry, School of Chemistry, Tel-Aviv, Israel                                  

 Full   Professor

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1. Jonathan Jeffet (ST), Asaf Kobo (ST), Tianxiang Su (ST), Assaf Grunwald (ST), Ori Green (ST), Adam N. Nilsson (ST), Eli Eisenberg (ST), Tobias Ambjörnsson (CI), Fredrik Westerlund (CI), Elmar Weinhold (CI), Doron Shabat (CI), Prashant K. Purohit (CI), and Yuval Ebenstein* (PI), Super-Resolution Genome Mapping in Silicon Nanochannels. ACS Nano (2016), 10 (11), 9823–9830

2. Noa Gilat (ST), Tzlil Tabachnik (ST), Amit Shwartz (ST), Tamar Shahal (CI), Dmitry Torchinsky (ST), Yael Michaeli (CI), Gil Nifker (ST), Shahar Zirkin* (CI) and Yuval Ebenstein* (PI), Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers. Clinical epigenetics (2017), 9(1), 70. DOI:10.1186/s13148-017-0368-9.

3. Tslil Gabrieli (ST), Hila Sharim (ST), Dena Fridman (ST), Nissim Arbib, Yael Michaeli (CI) and Yuval Ebenstein* (PI), Selective nanopore sequencing of human BRCA1 by Cas9-assisted targeting of chromosome segments (CATCH). Nucleic Acids Research (2018),46, 14, e87.  DOI: 10.1093/nar/gky411.

4. Tslil Gabrieli (ST), Hila Sharim (ST), Gil Nifker (ST), Jonathan Jeffet (ST), Tamar Shahal (CI), Rani Arielly (ST), Michal Levy-Sakin, Lily Hoch, Nissim Arbib, Yael Michaeli (CI) and Yuval Ebenstein* (PI), Epigenetic Optical Mapping of 5-Hydroxymethylcytosine in Nanochannel Arrays. ACS Nano (2018), 12, 7, 7148–7158. DOI: 10.1021/acsnano.8b03023.

5. Hila Sharim(ST), Assaf Grunwald(ST), Tslil Gabrieli(ST), Yael Michaeli(T), Sapir Margalit(ST), Dmitry Torchinsky(ST), Rani Arielly(ST), Gil Nifker(ST), Matyas Juhasz, Felix Gularek, Miguel Almalve, Brandon Dufault, Sreetama Sen Chandra, Alexander Liu, Surajit Bhattacharya, Yi-Wen Chen, Eric Vilain, Kathryn R Wagner, Jonathan Pevsner, Jeff Reifenberger, Ernest T Lam, Alex R Hastie, Han Cao, Hayk Barseghyan, Elmar Weinhold*(PI) and Yuval Ebenstein*(PI), Long-read single-molecule maps of the functional methylome. Genome Research (2019) 29:646–656. DOI: 10.1101/gr.240739.118.

6. Nikhil Jain, Tamar Shahal(T), Tslil Gabrieli(ST), Noa Gilat(ST), Dmitry Torchinsky(ST), Yael   Michaeli(T), Viola Vogel and Yuval Ebenstein*(PI), Global Modulation in DNA Epigenetics during Pro- Inflammatory Macrophage Activation. Epigenetics (2019), 14, 12, 1183-1193. doi:10.1080/15592294.2019.1638700.

7. Dmitry Torchinsky(ST), Yael Michaeli(T), Natalie R. Gassman and Yuval Ebenstein*(PI), Simultaneous detection of multiple DNA damage types by multi-colour fluorescent labelling. Chemical Communications (2019), 55, 11414-11417. https://doi.org/10.1039/C9CC05198H.

8. Sapir Margalit(ST), Sigal Avraham(ST), Tamar Shahal(T), Yael Michaeli(T), Noa Gilat(ST), Prerna Magod, Michal Caspi, Shelly Loewenstein, Guy Lahat, Dinorah Friedmann‐Morvinski, Revital Kariv, Rina Rosin‐Arbesfeld, Shahar Zirkin(T)  and Yuval Ebenstein* (PI), 5‐hydroxymethylcytosine as a clinical biomarker: Fluorescence‐based assay for high‐throughput epigenetic quantification in human tissues. International Journal of Cancer (2020),146, 1, 115-122.  https://doi.org/10.1002/ijc.32519.

9. Noa Gilat(ST), Dmitry Torchinsky(ST), Sapir Margalit(ST), Yael Michaeli(T), Sigal Avraham(ST), Hila Sharim(ST), Nadav Elkoshi, Carmit Levy, Shahar Zirkin(ST), Yuval Ebenstein*(PI), Rapid Quantification of Oxidation and UV Induced DNA Damage by Repair Assisted Damage Detection-(Rapid RADD). Anal Chem (2020), 92, 14, 9887–9894. https:/doi.org/10.1021/acs.analchem.0c01393.

10. Christian Heck (PD), Dmitry Torchinsky(ST), Gil Nifker(ST), Felix Gularek(ST) , Yael Michaeli(T), Elmar Weinhold , Yuval Ebenstein*(PI) , Label as you fold: methyltransferase-assisted functionalization of DNA nanostructures. Nanoscale (2020), 12, 20287-20291 (2020). DOI: 10.1039/d0nr03694c.