Dr. Mark Shein-Idelson

Dr. Shein-Idelson holds a MA in Physics (Technion), a BA in Physics (Tel-Aviv University) and a PhD in Electrical Engineering (Tel Aviv University). He completed a post-doctoral study in at the Max-Planck Institute for Brain Research in Frankfurt. He joined the Department of Neurobiology at Tel Aviv University on 2018.

Our lab is set to understand how collective neuronal activity is organized and how this organization sub-serves coding in the brain. We seek to expose the simple, most fundamental principles that underlie the multi-scale complexity of neuronal systems. To extract these principles, we take a unique perspective by exploring the “simpler” brains of reptiles. This choice is motivated by the acknowledgement that brains and neuronal coding schemes are products of evolution and can be flashed out by comparative approaches and optimal models systems.

Methodology

We employ a wide set of techniques to study the hitherto under-explored reptilian brain. Specifically, we use large-scale (thousands of electrodes) extra-cellular electrophysiology and intra-cellular electrophysiology to study circuits both ex-vivo and in-vivo. We develop data analysis approaches to deal with the overgrowing richness of our data sets. We couple our experiments with quantitative behavioral analysis to place brain dynamics in context. We build computational models to test ideas and develop theories.

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Shein-Idelson M, Pammer L, Hemberger M and Laurent G (2017). Large-scale mapping of cortical synaptic projections with extracellular electrode arrays. Nature Methods 14(9):882-890. Link

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Shein-Idelson M*,Ondracek J M*, Liaw H, Reiter S, Laurent G (2016). Slow Waves, Sharp-waves, Ripples and REM in Sleeping Dragons. Science. 352 (6285), 590-595. Link

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Fournier J,  Mueller C M,  Shein-Idelson M, Hemberger M, Laurent G (2016). Consensus-Based Sorting of Neuronal Spike Waveforms. PLoS ONE 11(8): e0160494. Link

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Shein-Idelson M, Cohen G, Ben-Jacob E, Hanein Y (2016). Modularity induced gating and delays in neuronal networks. PLoS Computational Biolology 12(4): e1004883. Link

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Naumann R K, Ondracek J M, Reiter S, Shein-Idelson M, Tosches M A, Yamawaki T M, Laurent G (2015). The reptilian brain. Current Biology 25 (8), 317–321.  Link

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Shein-Idelson M, Ben-Jacob E, Hanein Y (2011). Engineered neuronal circuits: A new platform for studying the role of modular topology. Frontiers in Neuroengineering 4:10. Link

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Herzog N, Shein-Idelson M, Hanein Y (2011). Optical validation of in vitro extra-cellular neuronal recordings. Journal of Neural Engineering 8(6),056008. Link

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Shein-Idelson M, Ben-Jacob E, Hanein Y (2010). Innate synchronous oscillations in freely-organized small neuronal circuits. PLoS One5(12), e14443. Link

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Greenbaum A, Anava S, Ayali A, Shein M, David-Pur M, Ben-Jacob E, Hanein Y (2009). One-to-one neuron-electrode interfacing. Journal of Neuroscience Methods 182(2), 219-224. Link

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Shoval A, Adams C, David-Pur M, Shein M, Hanein Y, Sernagor E, (2009). Carbon nanotube electrodes for effective interfacing with retinal tissue. Frontiers in Neuroengineering 2, 4. Link

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Shein M, Greenbaum A, Gabay T, Sorkin R, David-Pur M, Ben-Jacob E, Hanein Y (2009). Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays. Biomedical Microdevices 11(2), 495-501. Link

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Shein M, Volman V, Raichman N, Hanein Y, Ben-Jacob E (2008). Management of synchronized network activity by highly active neurons. Physical Biology 5(3), 036008. Link

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Baruchi I, Volman V, Raichman N, Shein M, Ben-Jacob E (2008). The emergence and properties of mutual synchronization in in vitro coupled cortical networks. European Journal of Neuroscience 28(9), 1825-1835. Link

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Rubinsky L, Raichman N, Baruchi I, Shein M, Lavee J, Frenk H, Ben-Jacob E (2007). Study of hypothermia on cultured neuronal networks using multi-electrode arrays. Journal of Neuroscience Methods 160(2), 288-293. Link

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Baruchi I, Grossman D, Volman V, Shein M, Hunter J, Towle VL, Ben-Jacob E (2006). Functional holography analysis: simplifying the complexity of dynamical networks. Chaos 16(1), 015112. Link