Dr. Iftach Yacoby

 The Laboratory of Renewable Energy Studies explores these topics: 

• Biotechnological Design of Algal Strains- We are transforming synthetic enzymes into different algal strains. We seek for stable efficient hydrogen producers to be employed for industrial hydrogen production. For achieving this goal, we are using state of the art equipment to grow and monitor the parameters of interest. 
• Bioengineering of Synthetic Enzymes- To bioengineer synthetic enzymes, we are exploiting energy (electron transfer) junctions.
• Study of Energy Transfer Bottlenecks- We are studying the enormous electron loss on-route from photosystem II to hydrogenase.

Lavie V, Becker M, Cohen-Kupiec R, Yacoby I, Koppel R, Wedenig M, Hutter-Paier B, Solomon BEFRH-phage immunization of Alzheimer's disease animal model improves behavioral performance in Morris water maze trials. J Mol Neurosci. 2004; 24(1):105-13.

Arbel M, Yacoby I, Solomon B. Inhibition of amyloid precursor protein processing by beta-secretase via site directed antibodies. PNAS 2005 May 24; 102(21):7718-23.

Yacoby I, Shamis M, Bar H, Sahbat D, Benhar I. Targeting anti bacterial agents by drug-carrying filamentous bacteriophages  Antimicrobial Agents and Chemotherapy 2006; 50(6): 2087-2097.

Yacoby I, Bar H, Benhar I. Targeted drug-carrying bacteriophages as anti bacterial nanomedicines.  Antimicrobial Agents and Chemotherapy 2007; 51(6): 2156-2163.

Bar H, Yacoby I, Benhar I.  These authors contributed equally to the work  Killing cancer cells by targeted drug-carrying phage nanomedicines.  BMC Biotechnology, 2008; 8(1):37

Yacoby I, Benhar I.  Invited Review-Targeted anti bacterial therapy.  Infectious Disorders – Drug Target 2007; 7(3):221-229.

Yacoby I, Benhar I.  Invited Review-Targeted Bacteriophages as Therapeutic Agents.  Expert opinion in drug delivary 2008; 5(3):321-9.

Yacoby I, Benhar I. Invited Review-Antibacterial nanomedicine.  Nanomedicine  2008; 3(3):329-341.

Yacoby I, Pochekailov S, Toporik H, Ghirardi ML, King PW, Zhang S.  Photosynthetic electron partitioning between [FeFe]-hydrogenase and ferredoxin:NADP+-oxidoreductase (FNR) enzymes in vitro. Proc Natl Acad Sci U S A (2011) 108: 9396-9401.

Yacoby I, Tegler L, Pochkailov S, Zhang S, King P.  Optimized Expression and Purification for High-Activity Preparations of Algal [FeFe]-Hydrogenase.  PLoS1 (2012) 7(4) e35886